skip to main content
Language:
Search Limited to: Search Limited to: Resource type Show Results with: Show Results with: Search type Index

3D bioprinting of biomimetic aortic vascular constructs with self-supporting cells

Biotechnology and bioengineering, 2015-04, Vol.112 (4), p.811-821 [Peer Reviewed Journal]

2014 Wiley Periodicals, Inc. ;ISSN: 0006-3592 ;EISSN: 1097-0290 ;DOI: 10.1002/bit.25493 ;PMID: 25384685 ;CODEN: BIBIAU

Full text available

Citations Cited by
  • Title:
    3D bioprinting of biomimetic aortic vascular constructs with self-supporting cells
  • Author: Kucukgul, Can ; Ozler, S. Burce ; Inci, Ilyas ; Karakas, Ezgi ; Irmak, Ster ; Gozuacik, Devrim ; Taralp, Alpay ; Koc, Bahattin
  • Subjects: 3-D printers ; 3D bioprinting ; Algorithms ; Animals ; Aorta ; Bioengineering ; biomimetic modeling ; Biomimetics ; Bioprinting - methods ; Cardiovascular disease ; Computation ; Construction ; Humans ; Imaging techniques ; Mice ; scaffold-free tissue engineering ; Skin & tissue grafts ; Three dimensional ; Three dimensional printing ; Tissue engineering ; Tissue Engineering - methods ; tissue engineering of macrovascular structures ; Transplants & implants
  • Is Part Of: Biotechnology and bioengineering, 2015-04, Vol.112 (4), p.811-821
  • Description: ABSTRACT Cardiovascular diseases are the leading cause of deaths throughout the world. Vascular diseases are mostly treated with autografts and blood vessel transplantations. However, traditional grafting methods have several problems including lack of suitable harvest sites, additional surgical costs for harvesting procedure, pain, infection, lack of donors, and even no substitutes at all. Recently, tissue engineering and regenerative medicine approaches are used to regenerate damaged or diseased tissues. Most of the tissue engineering investigations have been based on the cell seeding into scaffolds by providing a suitable environment for cell attachment, proliferation, and differentiation. Because of the challenges such as difficulties in seeding cells spatially, rejection, and inflammation of biomaterials used, the recent tissue engineering studies focus on scaffold‐free techniques. In this paper, the development of novel computer aided algorithms and methods are developed for 3D bioprinting of scaffold‐free biomimetic macrovascular structures. Computer model mimicking a real human aorta is generated using imaging techniques and the proposed computational algorithms. An optimized three‐dimensional bioprinting path planning are developed with the proposed self‐supported model. Mouse embryonic fibroblast (MEF) cell aggregates and support structures (hydrogels) are 3D bioprinted layer‐by‐layer according to the proposed self‐supported method to form an aortic tissue construct. Biotechnol. Bioeng. 2015;112: 811–821. © 2014 Wiley Periodicals, Inc. In this study, novel computer aided algorithms and methods are developed for 3D bioprinting of scaffold‐free biomimetic macrovascular structures. Imaging techniques and the developed computational algorithms are used for the generation of an anatomically correct human aorta model from medical images. A novel self‐supported path planning methodology is also developed in order to support live cell aggreagtres in 3D during bioprinting. An aortic tissue construct is 3D bioprinted layer‐by‐layer based on the generated path plan by using mouse embryonic fibroblast (MEF) cell aggregates and support structures (hydrogels).
  • Publisher: United States: Blackwell Publishing Ltd
  • Language: English
  • Identifier: ISSN: 0006-3592
    EISSN: 1097-0290
    DOI: 10.1002/bit.25493
    PMID: 25384685
    CODEN: BIBIAU
  • Source: MEDLINE
    Alma/SFX Local Collection
Back to results list
INSPIRE LIBRARY - TON DUC THANG UNIVERSITY (84-028) 37 755 057 Feedback
19 Nguyen Huu Tho St. Dist.7, HCM thuvien@tdtu.edu.vn

Copyright © 2017 INSPIRE LIBRARY - TON DUC THANG UNIVERSITY

Searching Remote Databases, Please Wait