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Toxic effects of colloidal nanosilver in zebrafish embryos

Journal of applied toxicology, 2014-05, Vol.34 (5), p.562-575 [Tạp chí có phản biện]

Copyright © 2014 John Wiley & Sons, Ltd. ;ISSN: 0260-437X ;EISSN: 1099-1263 ;DOI: 10.1002/jat.2975 ;PMID: 24395442

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Nhan đề:
Toxic effects of colloidal nanosilver in zebrafish embryos
Tác giả: Olasagasti, Maider ; Gatti, Antonietta M. ; Capitani, Federico ; Barranco, Alejandro ; Pardo, Miguel Angel ; Escuredo, Kepa ; Rainieri, Sandra
Chủ đề: Animals ; Biocompatibility ; Colloids ; Danio rerio ; Dose-Response Relationship, Drug ; Embryo, Nonmammalian - drug effects ; Embryo, Nonmammalian - ultrastructure ; Embryos ; Freshwater ; Gene Expression Regulation, Developmental - drug effects ; Lethal Dose 50 ; Metals ; Microscopy, Electron, Scanning ; Nanoparticles ; Nanoparticles - chemistry ; Nanostructure ; Nanotoxicity ; Silver ; Silver - chemistry ; Silver - pharmacokinetics ; Silver - toxicity ; Solutions ; Tissue Distribution ; Toxic ; Toxicity ; Toxicology ; Zebrafish ; Zebrafish - embryology ; Zebrafish - genetics
Là 1 phần của: Journal of applied toxicology, 2014-05, Vol.34 (5), p.562-575
Mô tả: ABSTRACT A variety of consumer products containing silver nanoparticles (Ag NPs) are currently marketed. However, their safety for humans and for the environment has not yet been established and no standard method to assess their toxicity is currently available. The objective of this work was to develop an effective method to test Ag NP toxicity and to evaluate the effects of ion release and Ag NP size on a vertebrate model. To this aim, the zebrafish animal model was exposed to a solution of commercial nanosilver. While the exposure of embryos still surrounded by the chorion did not allow a definite estimation of the toxic effects exerted by the compound, the exposure for 48 h of 3‐day‐old zebrafish hatched embryos afforded a reliable evaluation of the effects of Ag NPs. The effects of the exposure were detected especially at molecular level; in fact, some selected genes expressed differentially after the exposure. The Ag NP toxic performance was due to the combined effect of Ag+ ion release and Ag NP size. However, the effect of NP size was particularly detectable at the lowest concentration of nanosilver tested (0.01 mg l–1) and depended on the solubilization media. The results obtained indicate that in vivo toxicity studies of nanosilver should be performed with ad hoc methods (in this case using hatched embryos) that might be different depending on the type of nanosilver. Moreover, the addition of this compound to commercial products should take into consideration the Ag NP solubilization media. Copyright © 2014 John Wiley & Sons, Ltd. The objective of this work was to test the toxicity of commercial nanosilver and evaluate the effect of ion release and Ag NPs size on the zebrafish animal model, in order to assess the safety for the consumer who uses nanoproducts. The exposure for 48h of 3 days hatched embryos afforded a reliable estimation of Ag NPs effects. Toxicity was due to the combined effect of ions release and NPs size and was evaluated at molecular level. The size effect was evident at low concentrations and depended on the media used.
Nơi xuất bản: England: Blackwell Publishing Ltd
Ngôn ngữ: English
Số nhận dạng: ISSN: 0260-437X
EISSN: 1099-1263
DOI: 10.1002/jat.2975
PMID: 24395442
Nguồn: MEDLINE
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Toxic effects of colloidal nanosilver in zebrafish embryos

Copyright © 2014 John Wiley & Sons, Ltd. ;ISSN: 0260-437X ;EISSN: 1099-1263 ;DOI: 10.1002/jat.2975 ;PMID: 24395442

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