skip to main content
Language:
Search Limited to: Search Limited to: Resource type Show Results with: Show Results with: Search type Index

Medications Associated Polyp Reduction in Patients With Left-Sided Diverticulosis: 142

The American journal of gastroenterology, 2018-10, Vol.113 (Supplement), p.S79-S81 [Peer Reviewed Journal]

Copyright Wolters Kluwer Health Medical Research, Lippincott Williams & Wilkins Oct 2018 ;ISSN: 0002-9270 ;EISSN: 1572-0241 ;DOI: 10.14309/00000434-201810001-00142

Full text available

Citations Cited by
  • Title:
    Medications Associated Polyp Reduction in Patients With Left-Sided Diverticulosis: 142
  • Author: Sarvepalli, Shashank ; Garber, Ari ; Rothberg, Michael ; McMichael, John ; Morris-Stiff, Gareth ; Vargo, John J. ; Rizk, Maged ; Burke, Carol A.
  • Subjects: Aspirin ; Colonoscopy ; Impact analysis ; Polyps
  • Is Part Of: The American journal of gastroenterology, 2018-10, Vol.113 (Supplement), p.S79-S81
  • Description: Introduction: Left-sided diverticulosis (LDV) is an independent risk factor for colonic adenomas and sessile serrated polyps (SSPs). The pathogenesis of the increased risk of colonic polyps in LDV is unknown. A variety of medications have been associated with colorectal polyp and cancer prevention. However, the effect of medications on polyps in patients with diverticulosis has not been studied. Our aim was to assess the impact and association between medication exposure and adenoma detection rate (ADR) and sessile serrated polyp detection rate (SSPDR) in patients with and without LDV. Methods: Patients undergoing screening colonoscopy within the Cleveland Clinic were identified. Information including demographic characteristics, comorbidities, colonoscopic details, and medication use (aspirin, statin, ACE inhibitor, calcium channel blocker, angiotensin receptor blocker, Calcium, Vitamin D, estrogen, bisphosphonates) at the time of colonoscopy were obtained. Using these variables, multivariate logistic regression analysis adjusting for the cluster effect of individual endoscopist was performed to identify factors associated with l ADR and SSPDR, as well as for right (cecum to splenic flexure) and left (descending colon to anus) colon polyps. Impact analysis was performed using the multivariate model to study the effect of medications in the study population. Results: N=52,269 patients were included (48% were male; mean age was 59 years; 38% had LDV). ADR was 29.7% (27.5% in patients without LDV and 33% in patients with LDV), and SSPDR was 4.4% (4.3% in patients without LDV and 4.7% in patients with LDV). As noted in the multivariate analysis in Table-1, aspirin and calcium were associated with a reduced ADR in patients with LDV. In patients with LDV, aspirin was associated with reduced SSPDR. In patients without LDV, only aspirin was associated with a reduced ADR. Association between aspirin and calcium by colonic location was also computed (Table 1). Based on impact analysis, if all included patients with LDV used aspirin and calcium, the predicted ADR would be 29.6% compared to 35.6% without use of these medications (Figure 1a). Similarly, aspirin use was associated with SSPDR of 4.3% compared to 5.2% without aspirin (Figure 1b). Conclusion: Use of aspirin and calcium was associated with reduced ADR s and SSPDRs in patients with LDV. Future prospective studies are needed to assess the chemopreventative effects of these medications in patients with LDV.
  • Publisher: New York: Wolters Kluwer Health Medical Research, Lippincott Williams & Wilkins
  • Language: English
  • Identifier: ISSN: 0002-9270
    EISSN: 1572-0241
    DOI: 10.14309/00000434-201810001-00142
  • Source: ProQuest Central
Back to results list
INSPIRE LIBRARY - TON DUC THANG UNIVERSITY (84-028) 37 755 057 Feedback
19 Nguyen Huu Tho St. Dist.7, HCM thuvien@tdtu.edu.vn

Copyright © 2017 INSPIRE LIBRARY - TON DUC THANG UNIVERSITY

Searching Remote Databases, Please Wait