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Targeting signalling pathways and the immune microenvironment of cancer stem cells - a clinical update

Nature reviews. Clinical oncology, 2020-04, Vol.17 (4), p.204-232 [Peer Reviewed Journal]

COPYRIGHT 2020 Nature Publishing Group ;2019© Springer Nature Limited 2019 ;Springer Nature Limited 2019. ;ISSN: 1759-4774 ;EISSN: 1759-4782 ;DOI: 10.1038/s41571-019-0293-2 ;PMID: 31792354

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Title:
Targeting signalling pathways and the immune microenvironment of cancer stem cells - a clinical update
Author: Clara, Joseph A ; Monge, Cecilia ; Yang, Yingzi ; Takebe, Naoko
Subjects: Antineoplastic Agents - therapeutic use ; Cancer ; Cancer cells ; Cancer therapies ; Care and treatment ; Cell differentiation ; Cell self-renewal ; Cellular proteins ; Cellular signal transduction ; Development and progression ; Drug development ; Epithelial-Mesenchymal Transition - drug effects ; Epithelial-Mesenchymal Transition - immunology ; Genetic aspects ; Health aspects ; Homeostasis ; Humans ; Immune system ; Immune System - drug effects ; Immune System - immunology ; Immunotherapy ; Metastases ; Metastasis ; Methods ; Microenvironments ; Molecular Targeted Therapy - methods ; Neoplasm Recurrence, Local ; Neoplasms - drug therapy ; Neoplasms - immunology ; Neoplasms - pathology ; Neoplastic Stem Cells - drug effects ; Neoplastic Stem Cells - immunology ; Neoplastic Stem Cells - pathology ; Patient outcomes ; Phenotypes ; Progenitor cells ; Signal transduction ; Signal Transduction - drug effects ; Signal Transduction - immunology ; Stem cell research ; Stem cells ; Therapeutic applications ; Transplantation ; Tumor Microenvironment - drug effects ; Tumor Microenvironment - immunology ; Tumors ; Wnt protein
Is Part Of: Nature reviews. Clinical oncology, 2020-04, Vol.17 (4), p.204-232
Description: Cancer stem cells (CSCs) have important roles in tumour development, relapse and metastasis; the intrinsic self-renewal characteristics and tumorigenic properties of these cells provide them with unique capabilities to resist diverse forms of anticancer therapy, seed recurrent tumours, and disseminate to and colonize distant tissues. The findings of several studies indicate that CSCs originate from non-malignant stem or progenitor cells. Accordingly, inhibition of developmental signalling pathways that are crucial for stem and progenitor cell homeostasis and function, such as the Notch, WNT, Hedgehog and Hippo signalling cascades, continues to be pursued across multiple cancer types as a strategy for targeting the CSCs hypothesized to drive cancer progression - with some success in certain malignancies. In addition, with the renaissance of anticancer immunotherapy, a better understanding of the interplay between CSCs and the tumour immune microenvironment might be the key to unlocking a new era of oncological treatments associated with a reduced propensity for the development of resistance and with enhanced antimetastatic activity, thus ultimately resulting in improved patient outcomes. Herein, we provide an update on the progress to date in the clinical development of therapeutics targeting the Notch, WNT, Hedgehog and Hippo pathways. We also discuss the interactions between CSCs and the immune system, including the potential immunological effects of agents targeting CSC-associated developmental signalling pathways, and provide an overview of the emerging approaches to CSC-targeted immunotherapy.
Publisher: England: Nature Publishing Group
Language: English
Identifier: ISSN: 1759-4774
EISSN: 1759-4782
DOI: 10.1038/s41571-019-0293-2
PMID: 31792354
Source: MEDLINE
ProQuest Central

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Targeting signalling pathways and the immune microenvironment of cancer stem cells - a clinical update

COPYRIGHT 2020 Nature Publishing Group ;2019© Springer Nature Limited 2019 ;Springer Nature Limited 2019. ;ISSN: 1759-4774 ;EISSN: 1759-4782 ;DOI: 10.1038/s41571-019-0293-2 ;PMID: 31792354

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