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Flavonoid Derivatives from the Aerial Parts of Trifolium trichocephalum M. Bieb. and Their Antioxidant and Cytotoxic Activity

Records of natural products, 2017-06, Vol.11 (5), p.479

2017. Notwithstanding the ProQuest Terms and conditions, you may use this content in accordance with the associated terms available at http://www.acgpubs.org/RNP/2017/Volume11/Abstracts%2011.1/61-RNP-1703-057.htm ;ISSN: 1307-6167 ;EISSN: 1307-6167 ;DOI: 10.25135/rnp.61.17.03.057

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  • Title:
    Flavonoid Derivatives from the Aerial Parts of Trifolium trichocephalum M. Bieb. and Their Antioxidant and Cytotoxic Activity
  • Author: Renda, Gülin ; Özgen, Ufuk ; Ünal, Zeynep ; Sabuncuoğlu, Suna ; Palaska, Erhan ; Erdoğan Orhan, İlkay
  • Subjects: Cytotoxicity
  • Is Part Of: Records of natural products, 2017-06, Vol.11 (5), p.479
  • Description: Trifolium L. species with a rich isoflavone content have been used as expectorant, analgesic, antiseptic, tonic, and wound-healer in folk medicine. The aim of the study is to evaluate pharmacological properties of the extracts and isolated compounds of T. tricocephalum. Phytochemical investigation of the aerial parts of T. trichocephalum led to the isolation of daidzein, genistein, quercetin, and daidzein 4'-O-β-glucoside for the first time from this species. Isolated compounds along with the methanol extract, water, ethyl acetate and chloroform subextracts were tested for their radical scavenging and cytotoxic activity which was evaluated by MTT assay. According to the results of activity tests, extracts showed a concentration-dependent radical scavenging activity as well as cytotoxic effect on HepG2 cells at 400 μg/mL, whereas the compounds did not exert any obvious cytotoxic effect at tested concentrations.
  • Publisher: Gebze: ACG Publications
  • Language: English
  • Identifier: ISSN: 1307-6167
    EISSN: 1307-6167
    DOI: 10.25135/rnp.61.17.03.057
  • Source: GFMER Free Medical Journals
    ProQuest Central
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