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C78 FIBROSIS: MEDIATORS AND MODULATORS: The Role Of A Panel Of Pro-Fibrogenic Mirs In Fibrotic Lung Disorders

American journal of respiratory and critical care medicine, 2017-01, Vol.195 [Peer Reviewed Journal]

Copyright American Thoracic Society 2017 ;ISSN: 1073-449X ;EISSN: 1535-4970

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  • Title:
    C78 FIBROSIS: MEDIATORS AND MODULATORS: The Role Of A Panel Of Pro-Fibrogenic Mirs In Fibrotic Lung Disorders
  • Author: Meloni, F ; Inghilleri, S ; Carlo, S Di ; Cova, E ; Calabrese, F ; Piloni, D ; Zorzetto, M ; Divizia, L ; Politano, G ; Benso, A ; Vanaudenaerde, B ; Kessler, R ; Porzio, M ; Morbini, P ; Rossi, E
  • Subjects: Fibroblasts
  • Is Part Of: American journal of respiratory and critical care medicine, 2017-01, Vol.195
  • Description: Methods We evaluated miRNAs expression profile by ISH and RT-PCR quantification in a series of formalin-fixed and paraffin-embedded lung samples obtained from patients with IPF (n. 8), OP (n. 8), BOS (n. 12) and normal lung from organ donors. Results In BOS, COP and IPF/UIP miR-21 and miR-145 were expressed in fibroblasts of BO lesions, OP plugs and in fibroblast foci respectively, and in reactive alveolar epithelia; miR-146b expression correlated to the amount of inflammatory cell infiltrates and epithelial activation in all cases, while a weak expression was evident in OP and IPF/UIP lesions. miR-34a overexpression was associated with the activation of alveolar epithelia and to a lesser extent with fibroblast lesions in OP. miR-381 showed a weak expression in all diseases, and was localized especially in inflammatory cells.
  • Publisher: New York: American Thoracic Society
  • Language: English
  • Identifier: ISSN: 1073-449X
    EISSN: 1535-4970
  • Source: GFMER Free Medical Journals
    Alma/SFX Local Collection
    ProQuest Central
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