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Functional Carbon Quantum Dots as Medical Countermeasures to Human Coronavirus

ACS Applied Materials & Interfaces, 2019-11, Vol.11 (46), p.42964-42974 [Peer Reviewed Journal]

2019. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the associated terms available at https://www.acs.org/content/acs/en/terms.html ;Distributed under a Creative Commons Attribution 4.0 International License ;ISSN: 1944-8244 ;EISSN: 1944-8252 ;DOI: 10.1021/acsami.9b15032 ;PMID: 31633330

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Title:
Functional Carbon Quantum Dots as Medical Countermeasures to Human Coronavirus
Author: Łoczechin, Aleksandra ; Séron, Karin ; Barras, Alexandre ; Giovanelli, Emerson ; Belouzard, Sandrine ; Chen, Yen-Ting ; Metzler-Nolte, Nils ; Boukherroub, Rabah ; Dubuisson, Jean ; Szunerits, Sabine
Subjects: Antiviral Agents - pharmacology ; Carbon - chemistry ; Carbon - pharmacology ; Cell Line, Tumor ; Coronavirus 229E, Human - physiology ; Coronavirus Infections - drug therapy ; Coronavirus Infections - metabolism ; Coronavirus Infections - pathology ; Humans ; Life Sciences ; Quantum Dots - chemistry ; Quantum Dots - therapeutic use ; Virus Replication - drug effects
Is Part Of: ACS Applied Materials & Interfaces, 2019-11, Vol.11 (46), p.42964-42974
Description: Therapeutic options for the highly pathogenic human coronavirus (HCoV) infections are urgently needed. Anticoronavirus therapy is however challenging, as coronaviruses are biologically diverse and rapidly mutating. In this work, the antiviral activity of seven different carbon quantum dots (CQDs) for the treatment of human coronavirus HCoV-229E infections was investigated. The first generation of antiviral CQDs was derived from hydrothermal carbonization of ethylenediamine/citric acid as carbon precursors and postmodified with boronic acid ligands. These nanostructures showed a concentration-dependent virus inactivation with an estimated EC of 52 ± 8 μg mL . CQDs derived from 4-aminophenylboronic acid without any further modification resulted in the second-generation of anti-HCoV nanomaterials with an EC lowered to 5.2 ± 0.7 μg mL . The underlying mechanism of action of these CQDs was revealed to be inhibition of HCoV-229E entry that could be due to interaction of the functional groups of the CQDs with HCoV-229E entry receptors; surprisingly, an equally large inhibition activity was observed at the viral replication step.
Publisher: United States: American Chemical Society
Language: English
Identifier: ISSN: 1944-8244
EISSN: 1944-8252
DOI: 10.1021/acsami.9b15032
PMID: 31633330
Source: Coronavirus Research Database

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Functional Carbon Quantum Dots as Medical Countermeasures to Human Coronavirus

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