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Epigenetic deregulation of imprinting in congenital diseases of aberrant growth

BioEssays, 2006-05, Vol.28 (5), p.453-459 [Peer Reviewed Journal]

Copyright © 2006 Wiley Periodicals, Inc. ;2006 Wiley Periodicals, Inc. ;Distributed under a Creative Commons Attribution 4.0 International License ;ISSN: 0265-9247 ;EISSN: 1521-1878 ;DOI: 10.1002/bies.20407 ;PMID: 16615080

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Title:
Epigenetic deregulation of imprinting in congenital diseases of aberrant growth
Author: Delaval, Katia ; Wagschal, Alexandre ; Feil, Robert
Subjects: Beckwith-Wiedemann Syndrome - genetics ; Biochemistry, Molecular Biology ; Chromosomes, Human, Pair 11 - genetics ; Diabetes Mellitus - congenital ; Diabetes Mellitus - genetics ; DNA Methylation ; Epigenesis, Genetic ; Female ; Genomic Imprinting ; Growth Disorders - congenital ; Growth Disorders - genetics ; Humans ; Infant, Newborn ; Life Sciences ; Male ; Models, Genetic ; Pregnancy ; Syndrome
Is Part Of: BioEssays, 2006-05, Vol.28 (5), p.453-459
Description: Human chromosome 11p15 comprises two imprinted domains important in the control of fetal and postnatal growth. Novel studies1–3 establish that imprinting at one of these, the IGF2‐H19 domain, is epigenetically deregulated (with loss of DNA methylation) in Silver‐Russell Syndrome (SRS), a congenital disease of growth retardation and asymmetry. Previously, the exact opposite epigenetic alteration (gain of DNA methylation) had been detected at the domain's ‘imprinting control region’ (ICR) in patients with Beckwith‐Wiedemann Syndrome (BWS), a complex disorder of fetal overgrowth. However, more frequently, BWS is caused by loss of DNA methylation at the ICR that regulates the second imprinted domain at 11p15. Interestingly, a similar epigenetic alteration (with loss of methylation) at a putative ICR on human chromosome 6q24, is involved in transient neonatal diabetes mellitus (TNDM), a congenital disease with intrauterine growth retardation and a transient lack of insulin. Thus, fetal and postnatal growth is epigenetically controlled by different ICRs, at 11p15 and other chromosomal regions. BioEssays 28: 453–459, 2006. © 2006 Wiley Periodicals, Inc.
Publisher: Hoboken: Wiley Subscription Services, Inc., A Wiley Company
Language: English
Identifier: ISSN: 0265-9247
EISSN: 1521-1878
DOI: 10.1002/bies.20407
PMID: 16615080
Source: MEDLINE
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Epigenetic deregulation of imprinting in congenital diseases of aberrant growth

Copyright © 2006 Wiley Periodicals, Inc. ;2006 Wiley Periodicals, Inc. ;Distributed under a Creative Commons Attribution 4.0 International License ;ISSN: 0265-9247 ;EISSN: 1521-1878 ;DOI: 10.1002/bies.20407 ;PMID: 16615080

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