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Norepinephrine potentiates and serotonin depresses visual cortical responses by transforming eligibility traces

Nature communications, 2022-06, Vol.13 (1), p.3202-3202, Article 3202 [Peer Reviewed Journal]

2022. The Author(s). ;The Author(s) 2022. corrected publication 2022. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. ;The Author(s) 2022, corrected publication 2022 ;ISSN: 2041-1723 ;EISSN: 2041-1723 ;DOI: 10.1038/s41467-022-30827-1 ;PMID: 35680879

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  • Title:
    Norepinephrine potentiates and serotonin depresses visual cortical responses by transforming eligibility traces
  • Author: Hong, Su Z ; Mesik, Lukas ; Grossman, Cooper D ; Cohen, Jeremiah Y ; Lee, Boram ; Lee, Hey-Kyoung ; Hell, Johannes W ; Kirkwood, Alfredo
  • Subjects: Catecholamines ; Conversion ; Hebbian plasticity ; Learning ; Long-term potentiation ; Neuromodulation ; Norepinephrine ; Ocular dominance ; Plasticity ; Reinforcement ; Serotonin ; Synaptic plasticity ; Synaptic strength
  • Is Part Of: Nature communications, 2022-06, Vol.13 (1), p.3202-3202, Article 3202
  • Description: Reinforcement allows organisms to learn which stimuli predict subsequent biological relevance. Hebbian mechanisms of synaptic plasticity are insufficient to account for reinforced learning because neuromodulators signaling biological relevance are delayed with respect to the neural activity associated with the stimulus. A theoretical solution is the concept of eligibility traces (eTraces), silent synaptic processes elicited by activity which upon arrival of a neuromodulator are converted into a lasting change in synaptic strength. Previously we demonstrated in visual cortical slices the Hebbian induction of eTraces and their conversion into LTP and LTD by the retroactive action of norepinephrine and serotonin Here we show in vivo in mouse V1 that the induction of eTraces and their conversion to LTP/D by norepinephrine and serotonin respectively potentiates and depresses visual responses. We also show that the integrity of this process is crucial for ocular dominance plasticity, a canonical model of experience-dependent plasticity.
  • Publisher: England: Nature Publishing Group
  • Language: English
  • Identifier: ISSN: 2041-1723
    EISSN: 2041-1723
    DOI: 10.1038/s41467-022-30827-1
    PMID: 35680879
  • Source: PubMed Central
    ProQuest Central
    DOAJ Directory of Open Access Journals
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