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Three dimensional printed macroporous polylactic acid/hydroxyapatite composite scaffolds for promoting bone formation in a critical-size rat calvarial defect model

Science and technology of advanced materials, 2016-01, Vol.17 (1), p.136-148 [Peer Reviewed Journal]

2016 The Author(s). Published by National Institute for Materials Science in partnership with Taylor & Francis 2016 ;2016 The Author(s). Published by National Institute for Materials Science in partnership with Taylor & Francis. This work is licensed under the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. ;2016 The Author(s). Published by National Institute for Materials Science in partnership with Taylor & Francis 2016 The Author(s) ;ISSN: 1468-6996 ;EISSN: 1878-5514 ;DOI: 10.1080/14686996.2016.1145532 ;PMID: 27877865

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Title:
Three dimensional printed macroporous polylactic acid/hydroxyapatite composite scaffolds for promoting bone formation in a critical-size rat calvarial defect model
Author: Zhang, Haifeng ; Mao, Xiyuan ; Du, Zijing ; Jiang, Wenbo ; Han, Xiuguo ; Zhao, Danyang ; Han, Dong ; Li, Qingfeng
Subjects: 102 Porous/Nanoporous/Nanostructured materials ; 103 Composites ; 211 Scaffold/Tissue engineering/Drug delivery ; 30 Bio-inspired and biomedical materials ; Adhesion tests ; Alkaline phosphatase ; Bio-Inspired and Biomedical Materials ; Biocompatibility ; Biodegradable materials ; Biodegradation ; biomaterials ; Biomedical materials ; Bone demineralization ; Bone marrow ; Calcium phosphates ; Cell adhesion ; Cell adhesion & migration ; Computed tomography ; DBM ; Gene expression ; Hydroxyapatite ; PLA/HA ; Plastic surgery ; Polylactic acid ; Pore size ; Porosity ; Scaffolds ; Substitute bone ; Surgical implants ; Three dimensional printing ; Tissue engineering ; β-TCP
Is Part Of: Science and technology of advanced materials, 2016-01, Vol.17 (1), p.136-148
Description: We have explored the applicability of printed scaffold by comparing osteogenic ability and biodegradation property of three resorbable biomaterials. A polylactic acid/hydroxyapatite (PLA/HA) composite with a pore size of 500 μm and 60% porosity was fabricated by three-dimensional printing. Three-dimensional printed PLA/HA, β-tricalcium phosphate (β-TCP) and partially demineralized bone matrix (DBM) seeded with bone marrow stromal cells (BMSCs) were evaluated by cell adhesion, proliferation, alkaline phosphatase activity and osteogenic gene expression of osteopontin (OPN) and collagen type I (COL-1). Moreover, the biocompatibility, bone repairing capacity and degradation in three different bone substitute materials were estimated using a critical-size rat calvarial defect model in vivo. The defects were evaluated by micro-computed tomography and histological analysis at four and eight weeks after surgery, respectively. The results showed that each of the studied scaffolds had its own specific merits and drawbacks. Three-dimensional printed PLA/HA scaffolds possessed good biocompatibility and stimulated BMSC cell proliferation and differentiation to osteogenic cells. The outcomes in vivo revealed that 3D printed PLA/HA scaffolds had good osteogenic capability and biodegradation activity with no difference in inflammation reaction. Therefore, 3D printed PLA/HA scaffolds have potential applications in bone tissue engineering and may be used as graft substitutes in reconstructive surgery.
Publisher: United States: Taylor & Francis
Language: English
Identifier: ISSN: 1468-6996
EISSN: 1878-5514
DOI: 10.1080/14686996.2016.1145532
PMID: 27877865
Source: Taylor & Francis Open Access
PubMed Central
Alma/SFX Local Collection
ProQuest Central
DOAJ Directory of Open Access Journals

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Three dimensional printed macroporous polylactic acid/hydroxyapatite composite scaffolds for promoting bone formation in a critical-size rat calvarial defect model

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