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Role of Interferons in Mycobacterium tuberculosis Infection

Clinics and practice, 2022-09, Vol.12 (5), p.788-796 [Peer Reviewed Journal]

2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. ;2022 by the authors. 2022 ;ISSN: 2039-7283 ;ISSN: 2039-7275 ;EISSN: 2039-7283 ;DOI: 10.3390/clinpract12050082 ;PMID: 36286068

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  • Title:
    Role of Interferons in Mycobacterium tuberculosis Infection
  • Author: Shanmuganathan, Gaithrri ; Orujyan, Davit ; Narinyan, William ; Poladian, Nicole ; Dhama, Sanya ; Parthasarathy, Arpitha ; Ha, Alexandra ; Tran, Daniel ; Velpuri, Prathosh ; Nguyen, Kevin ; Venketaraman, Vishwanath
  • Subjects: Bacterial infections ; Cytokines ; Gene expression ; Granulomas ; IFN-α ; IFN-γ ; Immune system ; Infections ; Interferon ; Kinases ; Lungs ; M. tb ; Pathogenesis ; Pathogens ; Phosphorylation ; Review ; Signal transduction ; Tuberculosis ; type I IFN ; type II IFN ; type III IFN
  • Is Part Of: Clinics and practice, 2022-09, Vol.12 (5), p.788-796
  • Description: Considerable measures have been implemented in healthcare institutions to screen for and treat tuberculosis (TB) in developed countries; however, in low- and middle-income countries, many individuals still suffer from TB’s deleterious effects. TB is caused by an infection from the Mycobacterium tuberculosis (M. tb) bacteria. Symptoms of TB may range from an asymptomatic latent-phase affecting the pulmonary tract to a devastating active and disseminated stage that can cause central nervous system demise, musculoskeletal impairments, and genitourinary compromise. Following M. tb infection, cytokines such as interferons (IFNs) are released as part of the host immune response. Three main classes of IFNs prevalent during the immune defense include: type I IFN (α and β), type II IFN (IFN-γ), and type III IFN (IFN-λ). The current literature reports that type I IFN plays a role in diminishing the host defense against M. tb by attenuating T-cell activation. In opposition, T-cell activation drives type II IFN release, which is the primary cytokine mediating protection from M. tb by stimulating macrophages and their oxidative defense mechanisms. Type III IFN has a subsidiary part in improving the Th1 response for host cell protection against M. tb. Based on the current evidence available, our group aims to summarize the role that each IFN serves in TB within this literature review.
  • Publisher: Bari: MDPI AG
  • Language: English
  • Identifier: ISSN: 2039-7283
    ISSN: 2039-7275
    EISSN: 2039-7283
    DOI: 10.3390/clinpract12050082
    PMID: 36286068
  • Source: GFMER Free Medical Journals
    PubMed Central
    ROAD: Directory of Open Access Scholarly Resources
    ProQuest Central
    DOAJ Directory of Open Access Journals
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