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0.05% atropine on control of myopia progression in Chinese school children: a randomized 3-year clinical trial

International journal of ophthalmology, 2023-06, Vol.16 (6), p.939-946 [Peer Reviewed Journal]

International Journal of Ophthalmology Press. ;International Journal of Ophthalmology Press 2023 ;ISSN: 2222-3959 ;EISSN: 2227-4898 ;DOI: 10.18240/ijo.2023.06.17 ;PMID: 37332542

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  • Title:
    0.05% atropine on control of myopia progression in Chinese school children: a randomized 3-year clinical trial
  • Author: Zhu, Qin ; Tang, Guang-Yong ; Hua, Zhi-Juan ; Xue, Li-Ping ; Zhou, Yuan ; Zhang, Jie-Ying ; Zhu, Ying-Ting ; Zhang, Xiao-Fan
  • Subjects: atropine ; axial length ; children ; Clinical Research ; myopia ; spherical equivalent refraction
  • Is Part Of: International journal of ophthalmology, 2023-06, Vol.16 (6), p.939-946
  • Description: To evaluate the effect of 0.05% atropine on the control of myopia for 2y (phase I) and on spherical equivalent refraction (SER) progression for 1y (phase II) after its withdrawal in Chinese myopic children. Totally 142 children with myopia were randomly assigned to the 0.05% atropine group or to the placebo group. In phase I, children received 1 treatment for each eye daily. In phase II, the patients received no treatment. Axial length (AL), SER, intraocular pressure (IOP) and atropine-related side effects were assessed at 6 months' intervals. During phase I, the mean change of SER was -0.46±0.30 D in the atropine group, compared to -1.72±1.12 D in the placebo group ( <0.001). The mean change of AL in the atropine group (0.26±0.30 mm) was significantly shorter than that in the placebo group (0.76±0.62 mm, =0.002). In addition, in phase II (12mo after the withdrawal of atropine), there was no significant difference in AL change from the atropine group, when compared with that from the placebo group (0.31±0.25 mm 0.28±0.26 mm, >0.05). Furthermore, the change in SER from the atropine group was 0.50±0.41 D, which was significantly lower than 0.72±0.60 D from placebo group, ( <0.05). Finally, there were no statistically significant differences in IOP between the treatment and control groups at any stages (all >0.05). The use of 0.05% atropine for two consecutive years may effectively control elongation of AL and thus progression of myopia, without significant SER progression 1y after atropine withdrawal. Therefore, treatment with 0.05% atropine daily for 2y is effective and safe.
  • Publisher: China: International Journal of Ophthalmology Press
  • Language: English
  • Identifier: ISSN: 2222-3959
    EISSN: 2227-4898
    DOI: 10.18240/ijo.2023.06.17
    PMID: 37332542
  • Source: PubMed Central
    DOAJ Directory of Open Access Journals
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