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The biology, function, and applications of exosomes in cancer

Acta pharmaceutica Sinica. B, 2021-09, Vol.11 (9), p.2783-2797 [Peer Reviewed Journal]

2021 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences ;2021 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. Production and hosting by Elsevier B.V. 2021 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences ;ISSN: 2211-3835 ;EISSN: 2211-3843 ;DOI: 10.1016/j.apsb.2021.01.001 ;PMID: 34589397

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  • Title:
    The biology, function, and applications of exosomes in cancer
  • Author: Liu, Jinyi ; Ren, Liwen ; Li, Sha ; Li, Wan ; Zheng, Xiangjin ; Yang, Yihui ; Fu, Weiqi ; Yi, Jie ; Wang, Jinhua ; Du, Guanhua
  • Subjects: Biomarkers ; Drug delivery ; Drug resistance ; Exosomes ; Review ; Tumor immunity ; Tumor metastasis
  • Is Part Of: Acta pharmaceutica Sinica. B, 2021-09, Vol.11 (9), p.2783-2797
  • Description: Exosomes are cell-derived nanovesicles with diameters from 30 to 150 nm, released upon fusion of multivesicular bodies with the cell surface. They can transport nucleic acids, proteins, and lipids for intercellular communication and activate signaling pathways in target cells. In cancers, exosomes may participate in growth and metastasis of tumors by regulating the immune response, blocking the epithelial–mesenchymal transition, and promoting angiogenesis. They are also involved in the development of resistance to chemotherapeutic drugs. Exosomes in liquid biopsies can be used as non-invasive biomarkers for early detection and diagnosis of cancers. Because of their amphipathic structure, exosomes are natural drug delivery vehicles for cancer therapy. This review summarizes the biology, function, and applications of exosomes in cancers. Exosomes can be used as non-invasive biomarkers for early detection and diagnosis of cancers. Exosomes also act as natural drug delivery vehicles for cancer therapy. [Display omitted]
  • Publisher: Elsevier B.V
  • Language: English
  • Identifier: ISSN: 2211-3835
    EISSN: 2211-3843
    DOI: 10.1016/j.apsb.2021.01.001
    PMID: 34589397
  • Source: Geneva Foundation Free Medical Journals at publisher websites
    NCBI PubMed Central（免费）
    Directory of Open Access Journals: DOAJ
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