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Asymmetry in the Central Nervous System: A Clinical Neuroscience Perspective

Frontiers in systems neuroscience, 2021-12, Vol.15, p.733898-733898 [Peer Reviewed Journal]

Copyright © 2021 Mundorf, Peterburs and Ocklenburg. ;Copyright © 2021 Mundorf, Peterburs and Ocklenburg. 2021 Mundorf, Peterburs and Ocklenburg ;ISSN: 1662-5137 ;EISSN: 1662-5137 ;DOI: 10.3389/fnsys.2021.733898 ;PMID: 34970125

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  • Title:
    Asymmetry in the Central Nervous System: A Clinical Neuroscience Perspective
  • Author: Mundorf, Annakarina ; Peterburs, Jutta ; Ocklenburg, Sebastian
  • Subjects: brain structure ; clinical neuroscience ; hemispheric asymmetry ; laterality ; mental health ; Neuroscience ; psychopathology
  • Is Part Of: Frontiers in systems neuroscience, 2021-12, Vol.15, p.733898-733898
  • Description: Recent large-scale neuroimaging studies suggest that most parts of the human brain show structural differences between the left and the right hemisphere. Such structural hemispheric asymmetries have been reported for both cortical and subcortical structures. Interestingly, many neurodevelopmental and psychiatric disorders have been associated with altered functional hemispheric asymmetries. However, findings concerning the relation between structural hemispheric asymmetries and disorders have largely been inconsistent, both within specific disorders as well as between disorders. In the present review, we compare structural asymmetries from a clinical neuroscience perspective across different disorders. We focus especially on recent large-scale neuroimaging studies, to concentrate on replicable effects. With the notable exception of major depressive disorder, all reviewed disorders were associated with distinct patterns of alterations in structural hemispheric asymmetries. While autism spectrum disorder was associated with altered structural hemispheric asymmetries in a broader range of brain areas, most other disorders were linked to more specific alterations in brain areas related to cognitive functions that have been associated with the symptomology of these disorders. The implications of these findings are highlighted in the context of transdiagnostic approaches to psychopathology.
  • Publisher: Switzerland: Frontiers Media S.A
  • Language: English
  • Identifier: ISSN: 1662-5137
    EISSN: 1662-5137
    DOI: 10.3389/fnsys.2021.733898
    PMID: 34970125
  • Source: GFMER Free Medical Journals
    PubMed Central
    Alma/SFX Local Collection
    ROAD: Directory of Open Access Scholarly Resources
    DOAJ Directory of Open Access Journals
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