Language:

Nanocellulose-enriched hydrocolloid-based hydrogels designed using a Ca2+ free strategy based on citric acid

Materials & design, 2021-01, Vol.197, p.109200, Article 109200 [Peer Reviewed Journal]

2020 The Authors ;ISSN: 0264-1275 ;ISSN: 1873-4197 ;EISSN: 1873-4197 ;DOI: 10.1016/j.matdes.2020.109200

Full text available

Citations Cited by

Actions
1. Add to My Research
2. Remove from My Research
3. E-mail
4. Print
5. Permalink
6. Citation
7. EasyBib
8. EndNote
9. RefWorks
10. Delicious
11. Export RIS
12. Export BibTeX

Title:
Nanocellulose-enriched hydrocolloid-based hydrogels designed using a Ca2+ free strategy based on citric acid
Author: Lungu, Adriana ; Cernencu, Alexandra I. ; Dinescu, Sorina ; Balahura, Roxana ; Mereuta, Paul ; Costache, Marieta ; Syverud, Kristin ; Stancu, Izabela C. ; Iovu, Horia
Subjects: Acidic conditions ; Additives ; Biomolecules ; Biopolymers ; Ca2+ free hydrogels ; Calcium ; Cells ; Cellulose ; Cellulose nanocrystals ; Cellulose nanofibrils ; Cellulose nanofibrils (CNFs) ; Citric acid ; Citric acid-crosslinked hydrogels ; Conventional approach ; Cross-linked hydrogels ; Fibrils ; Gelation ; Hydrocolloids ; Hydrogels ; Mechanical characteristics ; Microenvironments ; Nanocellulose ; Naturally occurring ; Physical gelation ; Polysaccharide-based hydrogels ; Stem cells ; Type ; Wood-derived nanocellulose
Is Part Of: Materials & design, 2021-01, Vol.197, p.109200, Article 109200
Description: In this work fully biomass-based hydrogels were developed using a naturally occurring vegetable hydrocolloid co-mingled with wood-derived nanocellulose fibrils. Two distinct types of hydrocolloids have been considered: a seaweed-derived biopolymer (alginate) and a plant-derived biopolymer (pectin). To attain nano-structured binary hydrogels, surface-functionalized cellulose nanofibrils (CNFs) bearing carboxyl groups were employed. This study addresses a non-conventional approach of physical gelation that takes place in acidic conditions (pH < 3) at ambiental temperature using citric acid as gelation-inducing additive in comparison with the typical Ca2+-crosslinked hydrogels. The use of a specific crosslinker directly determines the gross properties of the material because of different type and density of polymer junctions and chains assembly. Therefore, the final features of the bioinspired scaffolds such as moisture uptake, morphological and mechanical characteristics are strongly influenced by the type of gelling additive used and by the ratio between the employed vegetal polysaccharides. Citric acid-based hydrogels presented a higher stability when compared to the calcium-mediated controls and a significantly higher proliferation was detected when raising the hydrocolloid content and when citric acid was used for crosslinking. The newly adopted crosslinking strategy provides a more cell-interactive microenvironment than calcium-based crosslinking leading to improved viability and cytoskeleton development of stem cells. [Display omitted] •Fully biomass-based nanostructured hydrogels were obtained by a novel non-conventional physical gelation using citric acid.•Hydrogels were prepared from vegetable hydrocolloids, namely alginate or pectin, each combined with oxidized nanocellulose.•Citric acid-crosslinked hydrogels provide more cell-friendly enem environments compared to the calcium-crosslinked counterparts.•Citric acid-crosslinked hydrogels present higher elasticity compared to calcium-crosslinked ones.
Publisher: Elsevier Ltd
Language: English
Identifier: ISSN: 0264-1275
ISSN: 1873-4197
EISSN: 1873-4197
DOI: 10.1016/j.matdes.2020.109200
Source: SWEPUB Freely available online
DOAJ Directory of Open Access Journals

Back to results list


INSPIRE LIBRARY - TON DUC THANG UNIVERSITY	(84-028) 37 755 057	Feedback
19 Nguyen Huu Tho St. Dist.7, HCM	thuvien@tdtu.edu.vn	Feedback

Nanocellulose-enriched hydrocolloid-based hydrogels designed using a Ca2+ free strategy based on citric acid

2020 The Authors ;ISSN: 0264-1275 ;ISSN: 1873-4197 ;EISSN: 1873-4197 ;DOI: 10.1016/j.matdes.2020.109200

Searching Remote Databases, Please Wait