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Mucus interaction to improve gastrointestinal retention and pharmacokinetics of orally administered nano-drug delivery systems

Journal of nanobiotechnology, 2022-08, Vol.20 (1), p.1-362, Article 362 [Peer Reviewed Journal]

COPYRIGHT 2022 BioMed Central Ltd. ;2022. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. ;The Author(s) 2022 ;ISSN: 1477-3155 ;EISSN: 1477-3155 ;DOI: 10.1186/s12951-022-01539-x ;PMID: 35933341

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  • Title:
    Mucus interaction to improve gastrointestinal retention and pharmacokinetics of orally administered nano-drug delivery systems
  • Author: Subramanian, Deepak A ; Langer, Robert ; Traverso, Giovanni
  • Subjects: Amino acids ; Bioavailability ; Drug delivery ; Drug delivery systems ; Drug interactions ; Drugs ; Evaluation ; Experiments ; Gastrointestinal system ; Gastrointestinal tract ; Health aspects ; Intestinal absorption ; Intestine ; Mucoadhesive ; Mucus ; Mucus penetration ; Nanoparticles ; Oral administration ; Oral delivery ; Pathogens ; Patient compliance ; Peptides ; Pharmacokinetics ; Pharmacology ; Pore size ; Proteins ; Review ; Small intestine ; Vehicles
  • Is Part Of: Journal of nanobiotechnology, 2022-08, Vol.20 (1), p.1-362, Article 362
  • Description: Oral delivery of therapeutics is the preferred route of administration due to ease of administration which is associated with greater patient medication adherence. One major barrier to oral delivery and intestinal absorption is rapid clearance of the drug and the drug delivery system from the gastrointestinal (GI) tract. To address this issue, researchers have investigated using GI mucus to help maximize the pharmacokinetics of the therapeutic; while mucus can act as a barrier to effective oral delivery, it can also be used as an anchoring mechanism to improve intestinal residence. Nano-drug delivery systems that use materials which can interact with the mucus layers in the GI tract can enable longer residence time, improving the efficacy of oral drug delivery. This review examines the properties and function of mucus in the GI tract, as well as diseases that alter mucus. Three broad classes of mucus-interacting systems are discussed: mucoadhesive, mucus-penetrating, and mucolytic drug delivery systems. For each class of system, the basis for mucus interaction is presented, and examples of materials that inform the development of these systems are discussed and reviewed. Finally, a list of FDA-approved mucoadhesive, mucus-penetrating, and mucolytic drug delivery systems is reviewed. In summary, this review highlights the progress made in developing mucus-interacting systems, both at a research-scale and commercial-scale level, and describes the theoretical basis for each type of system.
  • Publisher: London: BioMed Central Ltd
  • Language: English
  • Identifier: ISSN: 1477-3155
    EISSN: 1477-3155
    DOI: 10.1186/s12951-022-01539-x
    PMID: 35933341
  • Source: Open Access: DOAJ Directory of Open Access Journals
    Open Access: PubMed Central
    Geneva Foundation Free Medical Journals at publisher websites
    AUTh Library subscriptions: ProQuest Central
    Springer OA刊
    ROAD: Directory of Open Access Scholarly Resources
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