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Regular Physical Exercise Modulates Iron Homeostasis in the 5xFAD Mouse Model of Alzheimer’s Disease

International journal of molecular sciences, 2021-08, Vol.22 (16), p.8715 [Peer Reviewed Journal]

2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. ;2021 by the authors. 2021 ;ISSN: 1422-0067 ;ISSN: 1661-6596 ;EISSN: 1422-0067 ;DOI: 10.3390/ijms22168715 ;PMID: 34445419

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Title:
Regular Physical Exercise Modulates Iron Homeostasis in the 5xFAD Mouse Model of Alzheimer’s Disease
Author: Belaya, Irina ; Kucháriková, Nina ; Górová, Veronika ; Kysenius, Kai ; Hare, Dominic J. ; Crouch, Peter J. ; Malm, Tarja ; Atalay, Mustafa ; White, Anthony R. ; Liddell, Jeffrey R. ; Kanninen, Katja M.
Subjects: 5xFAD mouse ; Age ; Aging ; Alzheimer's disease ; Exercise ; Genotype & phenotype ; Hepcidin ; Homeostasis ; il-6 ; Inductively coupled plasma mass spectrometry ; Interleukin 6 ; Iron ; Janus kinase ; Lifestyles ; Mass spectrometry ; Mass spectroscopy ; Metabolic disorders ; Muscles ; Musculoskeletal system ; Physical exercise ; Physical fitness ; Proteins ; regular voluntary exercise ; Risk analysis ; Risk factors ; Skeletal muscle ; Stat3 protein
Is Part Of: International journal of molecular sciences, 2021-08, Vol.22 (16), p.8715
Description: Dysregulation of brain iron metabolism is one of the pathological features of aging and Alzheimer’s disease (AD), a neurodegenerative disease characterized by progressive memory loss and cognitive impairment. While physical inactivity is one of the risk factors for AD and regular exercise improves cognitive function and reduces pathology associated with AD, the underlying mechanisms remain unclear. The purpose of the study is to explore the effect of regular physical exercise on modulation of iron homeostasis in the brain and periphery of the 5xFAD mouse model of AD. By using inductively coupled plasma mass spectrometry and a variety of biochemical techniques, we measured total iron content and level of proteins essential in iron homeostasis in the brain and skeletal muscles of sedentary and exercised mice. Long-term voluntary running induced redistribution of iron resulted in altered iron metabolism and trafficking in the brain and increased iron content in skeletal muscle. Exercise reduced levels of cortical hepcidin, a key regulator of iron homeostasis, coupled with interleukin-6 (IL-6) decrease in cortex and plasma. We propose that regular exercise induces a reduction of hepcidin in the brain, possibly via the IL-6/STAT3/JAK1 pathway. These findings indicate that regular exercise modulates iron homeostasis in both wild-type and AD mice.
Publisher: Basel: MDPI AG
Language: English
Identifier: ISSN: 1422-0067
ISSN: 1661-6596
EISSN: 1422-0067
DOI: 10.3390/ijms22168715
PMID: 34445419
Source: PubMed Central
ProQuest Central
DOAJ Directory of Open Access Journals

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Regular Physical Exercise Modulates Iron Homeostasis in the 5xFAD Mouse Model of Alzheimer’s Disease

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