skip to main content
Guest
My Research
My Account
Sign out
Sign in
This feature requires javascript
Library Search
Find Databases
Browse Search
E-Journals A-Z
E-Books A-Z
Citation Linker
Help
Language:
English
Vietnamese
This feature required javascript
This feature requires javascript
Primo Search
All Library Resources
All
Course Materials
Course Materials
Search For:
Clear Search Box
Search in:
All Library Resources
Or hit Enter to replace search target
Or select another collection:
Search in:
All Library Resources
Search in:
Print Resources
Search in:
Digital Resources
Search in:
Online E-Resources
Advanced Search
Browse Search
This feature requires javascript
Search Limited to:
Search Limited to:
Resource type
criteria input
All items
Books
Articles
Images
Audio Visual
Maps
Graduate theses
Show Results with:
criteria input
that contain my query words
with my exact phrase
starts with
Show Results with:
Search type Index
criteria input
anywhere in the record
in the title
as author/creator
in subject
Full Text
ISBN
ISSN
TOC
Keyword
Field
Show Results with:
in the title
Show Results with:
anywhere in the record
in the title
as author/creator
in subject
Full Text
ISBN
ISSN
TOC
Keyword
Field
This feature requires javascript
Genistein Targets STING-Driven Antiviral Responses
mBio, 2022-08, Vol.13 (4), p.e0206422-e0206422
[Peer Reviewed Journal]
Copyright © 2022 Ullah et al. ;Copyright © 2022 Ullah et al. 2022 Ullah et al. ;ISSN: 2150-7511 ;EISSN: 2150-7511 ;DOI: 10.1128/mbio.02064-22 ;PMID: 35924852
Full text available
Citations
Cited by
View Online
Details
Recommendations
Reviews
Times Cited
External Links
This feature requires javascript
Actions
Add to My Research
Remove from My Research
E-mail
Print
Permalink
Citation
EasyBib
EndNote
RefWorks
Delicious
Export RIS
Export BibTeX
This feature requires javascript
Title:
Genistein Targets STING-Driven Antiviral Responses
Author:
Ullah, Tomalika R.
;
Balka, Katherine R.
;
Ambrose, Rebecca L.
;
Pépin, Geneviève
;
Wilce, Matthew C. J.
;
Wilce, Jacqueline A.
;
Thomas, Belinda J.
;
De Nardo, Dominic
;
Williams, Bryan R. G.
;
Gantier, Michael P.
Klein, Sabra
Subjects:
cGAMP
;
gap junction
;
Genistein
;
Molecular and Cellular Biology
;
Observation
;
STING inhibitor
Is Part Of:
mBio, 2022-08, Vol.13 (4), p.e0206422-e0206422
Description:
Cytoplasmic detection of DNA by cyclic GMP-AMP (cGAMP) synthase (cGAS) is an essential component of antiviral responses. Upon synthesis, cGAMP binds to the stimulator of interferon (IFN) genes (STING) in infected and adjacent cells through intercellular transfer by connexins forming gap-junctions, eliciting a strong IFN-β-driven antiviral response. We demonstrate here that Genistein, a flavonoid compound naturally occurring in soy-based foods, inhibits cGAS-STING antiviral signaling at two levels. First, Genistein pretreatment of cGAMP-producing cells inhibited gap-junction intercellular communication, resulting in reduced STING responses in adjacent cells. In addition, Genistein directly blocked STING activation by the murine agonist DMXAA, by decreasing the interaction of STING with TBK1 and IKKε. As a result, Genistein attenuated STING signaling in human and mouse cells, dampening antiviral activity against Semliki Forest Virus infection. Collectively, our findings identify a previously unrecognized proviral activity of Genistein mediated via its inhibitory effects at two levels of cGAS-STING signaling. IMPORTANCE Several reports suggest that Genistein exhibits antiviral activities against DNA viruses. Our work uncovers a previously unrecognized proviral effect of Genistein, through inhibition of the cGAS-STING pathway at the level of cGAMP transfer and its sensing by STING. This suggests that the use of Genistein as an antiviral should be taken with caution as it may reduce the protective antiviral effects elicited by host STING activation.
Publisher:
1752 N St., N.W., Washington, DC: American Society for Microbiology
Language:
English
Identifier:
ISSN: 2150-7511
EISSN: 2150-7511
DOI: 10.1128/mbio.02064-22
PMID: 35924852
Source:
DOAJ Directory of Open Access Journals
GFMER Free Medical Journals
PubMed Central
This feature requires javascript
This feature requires javascript
Back to results list
This feature requires javascript
This feature requires javascript
Searching Remote Databases, Please Wait
Searching for
in
scope:(TDTS),scope:(SFX),scope:(TDT),scope:(SEN),primo_central_multiple_fe
Show me what you have so far
This feature requires javascript
This feature requires javascript