Language:

Release of infectious virus and cytokines in nasopharyngeal swabs from individuals infected with non-alpha or alpha SARS-CoV-2 variants: an observational retrospective study

EBioMedicine, 2021-11, Vol.73, p.103637-103637, Article 103637 [Peer Reviewed Journal]

2021 The Authors ;Copyright © 2021 The Authors. Published by Elsevier B.V. All rights reserved. ;Attribution - NonCommercial - NoDerivatives ;2021 The Authors 2021 ;ISSN: 2352-3964 ;EISSN: 2352-3964 ;DOI: 10.1016/j.ebiom.2021.103637 ;PMID: 34678613

Full text available

Citations Cited by

Actions
1. Add to My Research
2. Remove from My Research
3. E-mail
4. Print
5. Permalink
6. Citation
7. EasyBib
8. EndNote
9. RefWorks
10. Delicious
11. Export RIS
12. Export BibTeX

Title:
Release of infectious virus and cytokines in nasopharyngeal swabs from individuals infected with non-alpha or alpha SARS-CoV-2 variants: an observational retrospective study
Author: Monel, Blandine ; Planas, Delphine ; Grzelak, Ludivine ; Smith, Nikaïa ; Robillard, Nicolas ; Staropoli, Isabelle ; Goncalves, Pedro ; Porrot, Françoise ; Guivel-Benhassine, Florence ; Guinet, Nathalie Demory ; Rodary, Julien ; Puech, Julien ; Euzen, Victor ; Bélec, Laurent ; Orvoen, Galdric ; Nunes, Léa ; Moulin, Véronique ; Fourgeaud, Jacques ; Wack, Maxime ; Imbeaud, Sandrine ; Campagne, Pascal ; Duffy, Darragh ; Santo, James P. Di ; Bruel, Timothée ; Péré, Hélène ; Veyer, David ; Schwartz, Olivier
Subjects: Adult ; Aged ; Antibodies, Viral - metabolism ; COVID-19 ; COVID-19 - pathology ; COVID-19 - virology ; Cytokines - metabolism ; Female ; Humans ; Immunoglobulin A - metabolism ; Immunoglobulin G - metabolism ; infectious particles ; Life Sciences ; Male ; Microbiology and Parasitology ; Middle Aged ; Nasal swabs ; Nasopharynx - virology ; Research paper ; Retrospective Studies ; SARS-CoV-2 ; SARS-CoV-2 - isolation & purification ; variants ; Virology
Is Part Of: EBioMedicine, 2021-11, Vol.73, p.103637-103637, Article 103637
Description: The dynamics of SARS-CoV-2 alpha variant shedding and immune responses at the nasal mucosa remain poorly characterised. We measured infectious viral release, antibodies and cytokines in 426 PCR+ nasopharyngeal swabs from individuals harboring non-alpha or alpha variants. With both lineages, viral titers were variable, ranging from 0 to >106 infectious units. Rapid antigenic diagnostic tests were positive in 94% of samples with infectious virus. 68 % of individuals carried infectious virus within two days after onset of symptoms. This proportion decreased overtime. Viable virus was detected up to 14 days. Samples containing anti-spike IgG or IgA did not generally harbor infectious virus. Ct values were slightly but not significantly lower with alpha. This variant was characterized by a fast decrease of infectivity overtime and a marked release of 13 cytokines (including IFN-b, IP-10 and IL-10). The alpha variant displays modified viral decay and cytokine profiles at the nasopharyngeal mucosae during symptomatic infection. This retrospective study has been funded by Institut Pasteur, ANRS, Vaccine Research Institute, Labex IBEID, ANR/FRM and IDISCOVR, Fondation pour la Recherche Médicale.
Publisher: Netherlands: Elsevier B.V
Language: English
Identifier: ISSN: 2352-3964
EISSN: 2352-3964
DOI: 10.1016/j.ebiom.2021.103637
PMID: 34678613
Source: Hyper Article en Ligne (HAL) (Open Access)
MEDLINE
PubMed Central
DOAJ Directory of Open Access Journals

Back to results list


INSPIRE LIBRARY - TON DUC THANG UNIVERSITY	(84-028) 37 755 057	Feedback
19 Nguyen Huu Tho St. Dist.7, HCM	thuvien@tdtu.edu.vn	Feedback

Release of infectious virus and cytokines in nasopharyngeal swabs from individuals infected with non-alpha or alpha SARS-CoV-2 variants: an observational retrospective study

2021 The Authors ;Copyright © 2021 The Authors. Published by Elsevier B.V. All rights reserved. ;Attribution - NonCommercial - NoDerivatives ;2021 The Authors 2021 ;ISSN: 2352-3964 ;EISSN: 2352-3964 ;DOI: 10.1016/j.ebiom.2021.103637 ;PMID: 34678613

Searching Remote Databases, Please Wait