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Nephrotoxicity after radionuclide therapies

Translational oncology, 2022-01, Vol.15 (1), p.101295-101295, Article 101295 [Peer Reviewed Journal]

2021 ;Copyright © 2021. Published by Elsevier Inc. ;2021 Published by Elsevier Inc. 2021 ;ISSN: 1936-5233 ;EISSN: 1936-5233 ;DOI: 10.1016/j.tranon.2021.101295 ;PMID: 34847420

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  • Title:
    Nephrotoxicity after radionuclide therapies
  • Author: Parihar, Ashwin Singh ; Chopra, Sejal ; Prasad, Vikas
  • Subjects: 177Lu ; 90Y ; Acute kidney injury ; Chronic ; CKD ; DOTATATE ; DOTATOC ; PRRT ; PSMA ; Radioimmunotherapy ; Renal toxicity ; RLT ; Theranostics
  • Is Part Of: Translational oncology, 2022-01, Vol.15 (1), p.101295-101295, Article 101295
  • Description: •Nuclear medicine theranostics have demonstrated success with a favourable safety and efficacy profile in several malignancies.•Kidneys being the primary excretory organ for most therapeutic radiopharmaceuticals are at risk of increased radiation exposure.•Recognition of the mechanisms of radiation induced nephropathy and associated risk factors can help in the development of appropriate interventions to prevent and limit renal toxicity.•Developments in reducing chronic radiation nephropathy following radionuclide therapies will help in avoiding the related morbidities, preserving the overall quality of life. Radioligand therapies have opened new treatment avenues for cancer patients. They offer precise tumor targeting with a favorable efficacy-to-toxicity profile. Specifically, the kidneys, once regarded as the critical organ for radiation toxicity, also show excellent tolerance to radiation doses as high as 50–60 Gy in selected cases. However, the number of nephrons that form the structural and functional units of the kidney is determined before birth and is fixed. Thus, loss of nephrons secondary to any injury may lead to an irreversible decline in renal function over time. Our primary understanding of radiation-induced nephropathy is derived from the effects of external beam radiation on the renal tissue. With the growing adoption of radionuclide therapies, considerable evidence has been gained with regard to the occurrence of renal toxicity and its associated risk factors. In this review, we discuss the radionuclide therapies associated with the risk of nephrotoxicity, the present understanding of the factors and mechanisms that contribute to renal injury, and the current and potential methods for preventing, identifying, and managing nephrotoxicity, specifically acute onset nephropathies. [Display omitted]
  • Publisher: United States: Elsevier Inc
  • Language: English
  • Identifier: ISSN: 1936-5233
    EISSN: 1936-5233
    DOI: 10.1016/j.tranon.2021.101295
    PMID: 34847420
  • Source: DOAJ Directory of Open Access Journals
    GFMER Free Medical Journals
    PubMed Central
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