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Imaging Collagen in Scar Tissue: Developments in Second Harmonic Generation Microscopy for Biomedical Applications

International journal of molecular sciences, 2017-08, Vol.18 (8), p.1772 [Peer Reviewed Journal]

Copyright MDPI AG 2017 ;2017 by the authors. 2017 ;ISSN: 1422-0067 ;ISSN: 1661-6596 ;EISSN: 1422-0067 ;DOI: 10.3390/ijms18081772 ;PMID: 28809791

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Title:
Imaging Collagen in Scar Tissue: Developments in Second Harmonic Generation Microscopy for Biomedical Applications
Author: Mostaço-Guidolin, Leila ; Rosin, Nicole L ; Hackett, Tillie-Louise
Subjects: Animals ; Biomedical materials ; Biomedical research ; Cicatrix - metabolism ; Cicatrix - pathology ; Collagen ; Collagen - metabolism ; Extracellular matrix ; Eye ; Eye injuries ; fibrillar collagen ; Humans ; Image analysis ; Image processing ; Imaging ; Information processing ; Ligaments ; lung ; Microscopy ; nonlinear optical microscopy ; Nonlinear Optical Microscopy - methods ; Optical microscopy ; Organs ; Physical properties ; Repair ; Review ; Reviews ; scar tissue ; Scars ; Second harmonic generation ; Skin ; Tissues ; vessels
Is Part Of: International journal of molecular sciences, 2017-08, Vol.18 (8), p.1772
Description: The ability to respond to injury with tissue repair is a fundamental property of all multicellular organisms. The extracellular matrix (ECM), composed of fibrillar collagens as well as a number of other components is dis-regulated during repair in many organs. In many tissues, scaring results when the balance is lost between ECM synthesis and degradation. Investigating what disrupts this balance and what effect this can have on tissue function remains an active area of research. Recent advances in the imaging of fibrillar collagen using second harmonic generation (SHG) imaging have proven useful in enhancing our understanding of the supramolecular changes that occur during scar formation and disease progression. Here, we review the physical properties of SHG, and the current nonlinear optical microscopy imaging (NLOM) systems that are used for SHG imaging. We provide an extensive review of studies that have used SHG in skin, lung, cardiovascular, tendon and ligaments, and eye tissue to understand alterations in fibrillar collagens in scar tissue. Lastly, we review the current methods of image analysis that are used to extract important information about the role of fibrillar collagens in scar formation.
Publisher: Switzerland: MDPI AG
Language: English
Identifier: ISSN: 1422-0067
ISSN: 1661-6596
EISSN: 1422-0067
DOI: 10.3390/ijms18081772
PMID: 28809791
Source: PubMed Central (Open access)
AUTh Library subscriptions: ProQuest Central
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Imaging Collagen in Scar Tissue: Developments in Second Harmonic Generation Microscopy for Biomedical Applications

Copyright MDPI AG 2017 ;2017 by the authors. 2017 ;ISSN: 1422-0067 ;ISSN: 1661-6596 ;EISSN: 1422-0067 ;DOI: 10.3390/ijms18081772 ;PMID: 28809791

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