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Progressive resistance training in head and neck cancer patients during concomitant chemoradiotherapy -- design of the DAHANCA 31 randomized trial

BMC cancer, 2017-06, Vol.17 (1), p.400-400, Article 400 [Peer Reviewed Journal]

COPYRIGHT 2017 BioMed Central Ltd. ;COPYRIGHT 2017 BioMed Central Ltd. ;Copyright BioMed Central 2017 ;The Author(s). 2017 ;ISSN: 1471-2407 ;EISSN: 1471-2407 ;DOI: 10.1186/s12885-017-3388-0 ;PMID: 28578654

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Title:
Progressive resistance training in head and neck cancer patients during concomitant chemoradiotherapy -- design of the DAHANCA 31 randomized trial
Author: Lonkvist, Camilla K ; Lønbro, Simon ; Vinther, Anders ; Zerahn, Bo ; Rosenbom, Eva ; Primdahl, Hanne ; Hojman, Pernille ; Gehl, Julie
Subjects: Aged ; Anemia ; Biochemical markers ; Body composition ; Body Composition - physiology ; Body mass ; Body Mass Index ; Cancer patients ; Cancer therapies ; Carcinoma, Squamous Cell - diagnostic imaging ; Carcinoma, Squamous Cell - physiopathology ; Carcinoma, Squamous Cell - therapy ; Care and treatment ; Chemoradiotherapy ; Chemoradiotherapy - adverse effects ; Chemotherapy ; Cytokines ; Denmark ; Dietary intake ; Dual energy X-ray absorptiometry ; Exercise ; Female ; Head & neck cancer ; Head and neck cancer ; Head and Neck Neoplasms - diagnostic imaging ; Head and Neck Neoplasms - physiopathology ; Head and Neck Neoplasms - therapy ; Head and neck squamous cell carcinoma ; Humans ; Larynx ; Lean body mass ; Male ; Middle Aged ; Muscle strength ; Muscle Strength - drug effects ; Muscle Strength - radiation effects ; Muscles ; Patient outcomes ; Patients ; Physical activity ; Physical fitness ; Physical training ; Physiological aspects ; Progressive resistance training ; Quality of Life ; Radiation therapy ; Resistance Training ; Squamous cell carcinoma ; Strength training ; Studies ; Study Protocol ; Weight training
Is Part Of: BMC cancer, 2017-06, Vol.17 (1), p.400-400, Article 400
Description: Head and neck cancer patients undergoing concomitant chemoradiotherapy (CCRT) frequently experience loss of muscle mass and reduced functional performance. Positive effects of exercise training are reported for many cancer types but biological mechanisms need further elucidation. This randomized study investigates whether progressive resistance training (PRT) may attenuate loss of muscle mass and functional performance. Furthermore, biochemical markers and muscle biopsies will be investigated trying to link biological mechanisms to training effects. At the Departments of Oncology at Herlev and Aarhus University Hospitals, patients with stage III/IV squamous cell carcinoma of the head and neck, scheduled for CCRT are randomized 1:1 to either a 12-week PRT program or control group, both with 1 year follow-up. Planned enrollment is 72 patients, and stratification variables are study site, sex, p16-status, and body mass index. Primary endpoint is difference in change in lean body mass (LBM) after 12 weeks of PRT, assessed by dual-energy X-ray absorptiometry (DXA). The hypothesis is that 12 weeks of PRT can attenuate the loss of LBM by at least 25%. Secondary endpoints include training adherence, changes in body composition, muscle strength, functional performance, weight, adverse events, dietary intake, self-reported physical activity, quality of life, labor market affiliation, blood biochemistry, plasma cytokine concentrations, NK-cell frequency in blood, sarcomeric protein content in muscles, as well as muscle fiber type and fiber size in muscle biopsies. Muscle biopsies are optional. This randomized study investigates the impact of a 12-week progressive resistance training program on lean body mass and several other physiological endpoints, as well as impact on adverse events and quality of life. Furthermore, a translational approach is integrated with extensive biological sampling and exploration into cytokines and mechanisms involved. The current paper discusses decisions and methods behind exercise in head and neck cancer patients undergoing concomitant chemoradiotherapy. Approved by the Regional Ethics Committee for the Capital Region of Denmark (protocol id: H-15003725) and registered retrospectively at ClinicalTrials.gov ( NCT02557529 ) September 11th 2015.
Publisher: England: BioMed Central Ltd
Language: English
Identifier: ISSN: 1471-2407
EISSN: 1471-2407
DOI: 10.1186/s12885-017-3388-0
PMID: 28578654
Source: GFMER Free Medical Journals
MEDLINE
PubMed Central
Springer Nature OA/Free Journals
ROAD: Directory of Open Access Scholarly Resources
ProQuest Central
DOAJ Directory of Open Access Journals

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Progressive resistance training in head and neck cancer patients during concomitant chemoradiotherapy -- design of the DAHANCA 31 randomized trial

COPYRIGHT 2017 BioMed Central Ltd. ;COPYRIGHT 2017 BioMed Central Ltd. ;Copyright BioMed Central 2017 ;The Author(s). 2017 ;ISSN: 1471-2407 ;EISSN: 1471-2407 ;DOI: 10.1186/s12885-017-3388-0 ;PMID: 28578654

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