skip to main content
Language:
Search Limited to: Search Limited to: Resource type Show Results with: Show Results with: Search type Index

Pathogenic Infection in Male Mice Changes Sperm Small RNA Profiles and Transgenerationally Alters Offspring Behavior

Cell reports (Cambridge), 2020-04, Vol.31 (4), p.107573-107573, Article 107573 [Peer Reviewed Journal]

2020 The Author(s) ;Copyright © 2020 The Author(s). Published by Elsevier Inc. All rights reserved. ;ISSN: 2211-1247 ;EISSN: 2211-1247 ;DOI: 10.1016/j.celrep.2020.107573 ;PMID: 32348768

Full text available

Citations Cited by
  • Title:
    Pathogenic Infection in Male Mice Changes Sperm Small RNA Profiles and Transgenerationally Alters Offspring Behavior
  • Author: Tyebji, Shiraz ; Hannan, Anthony J. ; Tonkin, Christopher J.
  • Subjects: Animals ; Behavior, Animal - physiology ; cognitive changes ; Disease Models, Animal ; epigenetics ; Epigenomics - methods ; Infections - complications ; Male ; Mice ; RNA - metabolism ; small RNA ; Spermatozoa - metabolism ; Toxoplasma gondii ; Toxoplasmosis - physiopathology ; transgenerational
  • Is Part Of: Cell reports (Cambridge), 2020-04, Vol.31 (4), p.107573-107573, Article 107573
  • Description: Germline epigenetic factors influence transgenerational inheritance of behavioral traits upon changes in experience and environment. Immune activation due to infection can also modulate brain function, but whether this experience can be passed down to offspring remains unknown. Here, we show that infection of the male lineage with the common human parasite Toxoplasma results in transgenerational behavioral changes in offspring in a sex-dependent manner. Small RNA sequencing of sperm reveals significant transcriptional differences of infected animals compared to controls. Zygote microinjection of total small RNA from sperm of infected mice partially recapitulates the behavioral phenotype of naturally born offspring, suggesting an epigenetic mechanism of behavioral inheritance in the first generation. Our results demonstrate that sperm epigenetic factors can contribute to intergenerational inheritance of behavioral changes after pathogenic infection, which could have major public health implications. [Display omitted] •F1 and F2 generation of T. gondii-infected males display behavioral abnormalities•Offspring behavioral changes display sexual dimorphism•T. gondii infection leads to changes in sperm small RNA levels•Zygotic microinjection of isolated sperm small RNA recapitulates behavioral changes Tyebji et al. provide evidence that paternal pathogenic infection has transgenerational impacts on offspring phenotypes. They discover that Toxoplasma gondii infection induces epigenetic changes, involving small RNAs, in mouse sperm and demonstrate a mechanism involving these non-coding RNAs. This mechanism mediates transgenerational inheritance modulating offspring phenotype, including behavior.
  • Publisher: United States: Elsevier Inc
  • Language: English
  • Identifier: ISSN: 2211-1247
    EISSN: 2211-1247
    DOI: 10.1016/j.celrep.2020.107573
    PMID: 32348768
  • Source: Cell Press Free Archives
    GFMER Free Medical Journals
    MEDLINE
    DOAJ Directory of Open Access Journals
Back to results list
INSPIRE LIBRARY - TON DUC THANG UNIVERSITY (84-028) 37 755 057 Feedback
19 Nguyen Huu Tho St. Dist.7, HCM thuvien@tdtu.edu.vn

Copyright © 2017 INSPIRE LIBRARY - TON DUC THANG UNIVERSITY

Searching Remote Databases, Please Wait