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Kinetics of the SARS-CoV-2 Antibody Avidity Response Following Infection and Vaccination

Viruses, 2022-07, Vol.14 (7), p.1491 [Peer Reviewed Journal]

COPYRIGHT 2022 MDPI AG ;2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. ;Attribution ;2022 by the authors. 2022 ;ISSN: 1999-4915 ;EISSN: 1999-4915 ;DOI: 10.3390/v14071491 ;PMID: 35891471

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Title:
Kinetics of the SARS-CoV-2 Antibody Avidity Response Following Infection and Vaccination
Author: Garcia, Laura ; Woudenberg, Tom ; Rosado, Jason ; Dyer, Adam H ; Donnadieu, Françoise ; Planas, Delphine ; Bruel, Timothée ; Schwartz, Olivier ; Prazuck, Thierry ; Velay, Aurélie ; Fafi-Kremer, Samira ; Batten, Isabella ; Reddy, Conor ; Connolly, Emma ; McElheron, Matt ; Kennelly, Sean P ; Bourke, Nollaig M ; White, Michael T ; Pelleau, Stéphane
Subjects: Analysis ; Antibodies ; Antibodies, Viral ; antibody ; Antibody Affinity ; Antigens ; Avidity ; Binding sites ; Bone marrow ; Coronaviruses ; COVID-19 ; COVID-19 Vaccines ; Enzymes ; Genomes ; Humans ; Immune response ; Immunoglobulin A ; Immunoglobulin G ; Immunoglobulins ; Infections ; Kinetics ; Life Sciences ; Medical personnel ; Membrane fusion ; multiplex ; Pandemics ; Patient outcomes ; Proteins ; SARS-CoV-2 ; Serology ; Severe acute respiratory syndrome coronavirus 2 ; Spike Glycoprotein, Coronavirus ; Vaccination
Is Part Of: Viruses, 2022-07, Vol.14 (7), p.1491
Description: Serological assays capable of measuring antibody responses induced by previous infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have been critical tools in the response to the COVID-19 pandemic. In this study, we use bead-based multiplex assays to measure IgG and IgA antibodies and IgG avidity to five SARS-CoV-2 antigens (Spike (S), receptor-binding domain (RBD), Nucleocapsid (N), S subunit 2, and Membrane-Envelope fusion (ME)). These assays were performed in several cohorts of healthcare workers and nursing home residents, who were followed for up to eleven months after SARS-CoV-2 infection or up to six months after vaccination. Our results show distinct kinetic patterns of antibody quantity (IgG and IgA) and avidity. While IgG and IgA antibody levels waned over time, with IgA antibody levels waning more rapidly, avidity increased with time after infection or vaccination. These contrasting kinetic patterns allow for the estimation of time since previous SARS-CoV-2 infection. Including avidity measurements in addition to antibody levels in a classification algorithm for estimating time since infection led to a substantial improvement in accuracy, from 62% to 78%. The inclusion of antibody avidity in panels of serological assays can yield valuable information for improving serosurveillance during SARS-CoV-2 epidemics.
Publisher: Basel: MDPI AG
Language: English
Identifier: ISSN: 1999-4915
EISSN: 1999-4915
DOI: 10.3390/v14071491
PMID: 35891471
Source: Hyper Article en Ligne (HAL) (Open Access)
GFMER Free Medical Journals
PubMed Central
ROAD: Directory of Open Access Scholarly Resources
ProQuest Central
DOAJ Directory of Open Access Journals

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Kinetics of the SARS-CoV-2 Antibody Avidity Response Following Infection and Vaccination

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