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Ovine pulmonary adenocarcinoma (OPA) in sheep: an update on epidemiology, pathogenesis and diagnosis
Journal of experimental biology and agricultural sciences, 2023-12, Vol.11 (6), p.997-1009
ISSN: 2320-8694 ;EISSN: 2320-8694 ;DOI: 10.18006/2023.11(6).997.1009
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Title:
Ovine pulmonary adenocarcinoma (OPA) in sheep: an update on epidemiology, pathogenesis and diagnosis
Author:
N, Shivasharanappa
;
B N, Dheeraj Reddy
;
K N, Apoorva
;
L, Rashmi
;
Suresh, K P
;
Gulati, Baldev R
;
S Patil, Sharanagouda
Is Part Of:
Journal of experimental biology and agricultural sciences, 2023-12, Vol.11 (6), p.997-1009
Description:
Ovine pulmonary adenocarcinoma (OPA) is a spontaneous lung tumor in sheep caused by Jaagsiekte sheep retrovirus (JSRV) belonging to the Retroviridae. The primary aim of this review work is to give brief insights into the epidemiological aspects of OPA based on a meta-analysis of available research work. This review article also discussed pathogenesis, diagnostic tests and control strategies available for OPA in Sheep. This will help in developing future strategies for disease-free status in India. This disease is endemic in Europe, Africa, Asia, and American continents, causing significant economic losses due to chronic respiratory illness and persistent infections in flocks. The virus is unique among retroviruses with selective affinity to lungs and is the only virus known to cause spontaneous lung tumors in sheep. The incubation time ranges for sheep with naturally occurring OPA ranged from one to four years. There are two pathological forms of the disease: classical and atypical. At an early stage, OPA is difficult to detect in sheep due to a lack of preclinical diagnostic methods, as JSRV is poorly immunogenic and doesn't induce an immune response. PCR, histopathology, and immunohistochemistry are recommended methods for OIE diagnosis. To become a JSRV-free country, mandatory surveillance, detection, and removal of positive animals are required, as OPA is difficult to control due to a lack of vaccines and preclinical diagnostic tests. Due to its similar histological and molecular pathogenesis to that of human lung cancer, OPA is considered an ideal large animal model of human lung adenocarcinoma.
Language:
English
Identifier:
ISSN: 2320-8694
EISSN: 2320-8694
DOI: 10.18006/2023.11(6).997.1009
Source:
GFMER Free Medical Journals
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