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Fractional anisotropy estimation of the pyramidal tracts, dorsal columns and anterior horns in normal ageing and pathologic conditions in the cervical spinal cord

Clinical neuroradiology (Munich), 2018-09, Vol.28 (S1), p.S75 [Peer Reviewed Journal]

COPYRIGHT 2018 Springer ;ISSN: 1869-1439 ;EISSN: 1869-1447 ;DOI: 10.1007/S00062-018-0719-8

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  • Title:
    Fractional anisotropy estimation of the pyramidal tracts, dorsal columns and anterior horns in normal ageing and pathologic conditions in the cervical spinal cord
  • Author: Lindig, Tobias ; Bender, Benjamin ; Rattay, Tim W ; Schols, Ludger ; Nagele, Thomas ; Ernemann, Ulrike ; Klose, Uwe
  • Subjects: Anisotropy
  • Is Part Of: Clinical neuroradiology (Munich), 2018-09, Vol.28 (S1), p.S75
  • Description: Purpose: To quantify white matter anisotropy of the human cervical spinal cord is still a challenge. The purpose of this work is to develop a standardized evaluation method for a robust FA estimation of the pyramidal tracts (PT), dorsal columns (DC) and anterior horns (AH) in normal ageing and pathologic conditions. Methods: A monopolar EPI sequence with double spin-echo diffusion preparation optimized for both a high SNR and a high axial in-plane resolution of 0.8 [mm.sup.2] was used. Impairment of the upper spinal cord was assessed in cross sectional images of 77 healthy subjects and 30 patients with hereditary spastic paraplegia (HSP) at 3T. To allow a semi-automated, bilateral ROI evaluation of the PT, DC and AH an ellipsoid was adjusted onto the individual FA image of each subject's spinal cord (Fig. 1). Results: Fig. 2 shows stable FA values from 18 years to the age of 65 for the PT (0.56, SD 0.03), DC (0.57, SD 0.03) and AH (0.38, SD 0.04). No decline of FA values can be demonstrated in normal ageing, at least until the age of 65. Fig. 3 shows a significant (p < .001) reduction in mean FA values of the pyramidal tracts of spastic paraplegia patients compared to controls. As HSP is the prototype disease of the degenerating first motor neuron, the measured decline in FA reflects well this pathologic condition. Conclusion: Spinal DTI of the upper cervical cord is clinically feasible at 3T, enabling robust FA measurements of PT, DC and AH in normal ageing and pathologic conditions.
  • Publisher: Springer
  • Language: English
  • Identifier: ISSN: 1869-1439
    EISSN: 1869-1447
    DOI: 10.1007/S00062-018-0719-8
  • Source: ProQuest Central
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