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Preparation of a novel curcumin nanoemulsion by ultrasonication and its comparative effects in wound healing and the treatment of inflammation

RSC advances, 2019-06, Vol.9 (35), p.2192-226 [Peer Reviewed Journal]

This journal is © The Royal Society of Chemistry. ;This journal is © The Royal Society of Chemistry 2019 The Royal Society of Chemistry ;ISSN: 2046-2069 ;EISSN: 2046-2069 ;DOI: 10.1039/c9ra03102b ;PMID: 35514703

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  • Title:
    Preparation of a novel curcumin nanoemulsion by ultrasonication and its comparative effects in wound healing and the treatment of inflammation
  • Author: Ahmad, Niyaz ; Ahmad, Rizwan ; Al-Qudaihi, Ali ; Alaseel, Salman Edrees ; Fita, Ibrahim Zuhair ; Khalid, Mohammed Saifuddin ; Pottoo, Faheem Hyder
  • Subjects: Chemistry ; Dependent variables ; Drug delivery systems ; Independent variables ; Mathematical analysis ; Nanoemulsions ; Optimization ; Refractivity ; Surfactants ; Titration ; Transdermal medication ; Wound healing ; Zeta potential
  • Is Part Of: RSC advances, 2019-06, Vol.9 (35), p.2192-226
  • Description: The aim of this study was to develop and evaluate a curcumin (Cur) nanoemulsion (NE) and enhance transdermal drug delivery. The comparative effects of Cur-NE were evaluated in terms of wound healing and anti-inflammatory action. Clove oil (oil), Tween-80 (surfactant), and PEG-400 (co-surfactant) were selected on the basis of their solubility and maximum nanoemulsion region. An aqueous micro-titration method with high-energy ultrasonication was used for the preparation of Cur-NE. This method was optimized to find the best NE, followed by a five-factor, three-level, central composite design. % oil, % S mix , ultrasonication time (min), ultrasonication intensity (%), and temperature (°C) were selected and optimized as independent variables. The optimized NE had parameters of 5.0% oil, 10% S mix , ultrasonication time (10 min), 40% ultrasonication intensity and 50 °C temperature, which were applied as independent and dependent variables. On the basis of experimental data of the dependent variables, we calculated a hydrodynamic diameter of 93.64 ± 6.48 nm, transmittance of 98.64 ± 0.37%, and PDI of 0.263 ± 0.021. TEM and SEM results revealed the smooth and spherical shape of the particles in the NE, with a zeta potential of −11.67 ± 0.11, refractive index of 1.71 ± 0.034, viscosity of 37 ± 7 cp, pH of 7.4 ± 0.07, and drug content of 98.11 ± 0.16% for the optimized Cur-NE. Cur-NE optimization with clove oil, Tween-80, and PEG-400 might be useful for enhancing the skin permeation of Cur. In conclusion, Cur-NE played a significant role in wound healing and exhibited anti-inflammatory effects, demonstrating its potential as a nanoformulation for safe and nontoxic transdermal delivery. The aim of this study was to develop and evaluate a curcumin (Cur) nanoemulsion (NE) and enhance transdermal drug delivery.
  • Publisher: England: Royal Society of Chemistry
  • Language: English
  • Identifier: ISSN: 2046-2069
    EISSN: 2046-2069
    DOI: 10.1039/c9ra03102b
    PMID: 35514703
  • Source: PubMed Central
    DOAJ Directory of Open Access Journals
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