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Activatable molecular agents for cancer theranostics

Chemical science (Cambridge), 2020, Vol.11 (3), p.618-63 [Peer Reviewed Journal]

This journal is © The Royal Society of Chemistry. ;Copyright Royal Society of Chemistry 2020 ;This journal is © The Royal Society of Chemistry 2020 The Royal Society of Chemistry ;ISSN: 2041-6520 ;EISSN: 2041-6539 ;DOI: 10.1039/c9sc05460j ;PMID: 34123034

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  • Title:
    Activatable molecular agents for cancer theranostics
  • Author: Zhang, Jianjian ; Ning, Lulu ; Huang, Jiaguo ; Zhang, Chi ; Pu, Kanyi
  • Subjects: Biocompatibility ; Biomarkers ; Biomedical materials ; Cancer ; Cancer therapies ; Chemistry ; Chemotherapy ; Medical imaging ; Photodynamic therapy ; Real time ; Signal to noise ratio ; Toxicity
  • Is Part Of: Chemical science (Cambridge), 2020, Vol.11 (3), p.618-63
  • Description: Theranostics that integrates diagnosis and treatment modalities has attracted great attention due to its abilities of personalized therapy and real-time monitoring of therapeutic outcome. Such a theranostic paradigm requires agents to simultaneously possess the capabilities of targeting, imaging, and treatment. Activatable molecular agents (AMAs) are promising for cancer theranostics, as they show a higher signal-to-noise ratio (SNR), real-time detection of cancer-associated biomarkers, lower normal tissue toxicity, and a higher therapeutic effect. This perspective summarizes the recent advancements of AMAs, which include imaging-guided chemotherapy, imaging-guided photodynamic therapy, and imaging-guided photothermal therapy. The molecular design principles, theranostic mechanisms, and biomedical applications of AMAs are described, followed by a discussion of potential challenges of AMAs in cancer theranostics. Activatable molecualr agents that intergrate diagnosis and treatment modalities have attracted great attention due to its abilities of personalized therapy and real-time monitoring of therapeutic outcome.
  • Publisher: England: Royal Society of Chemistry
  • Language: English
  • Identifier: ISSN: 2041-6520
    EISSN: 2041-6539
    DOI: 10.1039/c9sc05460j
    PMID: 34123034
  • Source: PubMed Central
    DOAJ Directory of Open Access Journals
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