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Fast and accurate long-read assembly with wtdbg2

Nature methods, 2020-02, Vol.17 (2), p.155-158 [Peer Reviewed Journal]

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Title:
Fast and accurate long-read assembly with wtdbg2
Author: Ruan, Jue ; Li, Heng
Subjects: Algorithms ; Assembly ; Central processing units ; CPUs ; Datasets as Topic ; Gene sequencing ; Genome, Human ; Genomes ; Genomics ; High-Throughput Nucleotide Sequencing - methods ; Humans ; Microprocessors
Is Part Of: Nature methods, 2020-02, Vol.17 (2), p.155-158
Description: Existing long-read assemblers require thousands of central processing unit hours to assemble a human genome and are being outpaced by sequencing technologies in terms of both throughput and cost. We developed a long-read assembler wtdbg2 (https://github.com/ruanjue/wtdbg2) that is 2-17 times as fast as published tools while achieving comparable contiguity and accuracy. It paves the way for population-scale long-read assembly in future.
Publisher: United States: Nature Publishing Group
Language: English
Identifier: ISSN: 1548-7091
EISSN: 1548-7105
DOI: 10.1038/s41592-019-0669-3
PMID: 31819265
Source: MEDLINE
ProQuest Central

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