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The impact of COVID-19 on pregnancy outcomes: a systematic review and meta-analysis

Canadian Medical Association journal (CMAJ), 2021-04, Vol.193 (16), p.E540-E548 [Peer Reviewed Journal]

2021 CMA Joule Inc. or its licensors. ;COPYRIGHT 2021 Joule Inc. ;COPYRIGHT 2021 CMA Joule Inc. ;Copyright Joule Inc Apr 19, 2021 ;2021 CMA Joule Inc. or its licensors 2021 ;ISSN: 0820-3946 ;EISSN: 1488-2329 ;DOI: 10.1503/cmaj.202604 ;PMID: 33741725

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Title:
The impact of COVID-19 on pregnancy outcomes: a systematic review and meta-analysis
Author: Wei, Shu Qin ; Bilodeau-Bertrand, Marianne ; Liu, Shiliang ; Auger, Nathalie
Subjects: Asymptomatic ; Bias ; Birth weight ; Clinical outcomes ; Confidence intervals ; Coronaviruses ; COVID-19 ; COVID-19 - complications ; COVID-19 - epidemiology ; Diabetes, Gestational - epidemiology ; Estimates ; Female ; Gestational diabetes ; Humans ; Infant, Low Birth Weight ; Infant, Newborn ; Infections ; Infectious Disease Transmission, Vertical ; Meta-analysis ; Observational Studies as Topic ; Obstetrical research ; Pandemics ; Patient outcomes ; Pneumonia ; Pre-Eclampsia - epidemiology ; Preeclampsia ; Pregnancy ; Pregnancy Complications, Infectious - epidemiology ; Pregnancy Outcome - epidemiology ; Pregnancy, Complications of ; Premature birth ; Premature Birth - epidemiology ; Risk factors ; SARS-CoV-2 ; Severe acute respiratory syndrome coronavirus 2 ; Stillbirth ; Stillbirth - epidemiology ; Systematic review
Is Part Of: Canadian Medical Association journal (CMAJ), 2021-04, Vol.193 (16), p.E540-E548
Description: The impact of coronavirus disease 2019 (COVID-19) on maternal and newborn health is unclear. We aimed to evaluate the association between severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection during pregnancy and adverse pregnancy outcomes. We conducted a systematic review and meta-analysis of observational studies with comparison data on SARS-CoV-2 infection and severity of COVID-19 during pregnancy. We searched for eligible studies in MEDLINE, Embase, ClinicalTrials.gov, medRxiv and Cochrane databases up to Jan. 29, 2021, using Medical Subject Headings terms and keywords for "severe acute respiratory syndrome coronavirus 2 OR SARS-CoV-2 OR coronavirus disease 2019 OR COVID-19" AND "pregnancy." We evaluated the methodologic quality of all included studies using the Newcastle-Ottawa Scale. Our primary outcomes were preeclampsia and preterm birth. Secondary outcomes included stillbirth, gestational diabetes and other pregnancy outcomes. We calculated summary odds ratios (ORs) or weighted mean differences with 95% confidence intervals (CI) using random-effects meta-analysis. We included 42 studies involving 438 548 people who were pregnant. Compared with no SARS-CoV-2 infection in pregnancy, COVID-19 was associated with preeclampsia (OR 1.33, 95% CI 1.03 to 1.73), preterm birth (OR 1.82, 95% CI 1.38 to 2.39) and stillbirth (OR 2.11, 95% CI 1.14 to 3.90). Compared with mild COVID-19, severe COVID-19 was strongly associated with preeclampsia (OR 4.16, 95% CI 1.55 to 11.15), preterm birth (OR 4.29, 95% CI 2.41 to 7.63), gestational diabetes (OR 1.99, 95% CI 1.09 to 3.64) and low birth weight (OR 1.89, 95% CI 1.14 to 3.12). COVID-19 may be associated with increased risks of preeclampsia, preterm birth and other adverse pregnancy outcomes.
Publisher: Canada: Joule Inc
Language: English
Identifier: ISSN: 0820-3946
EISSN: 1488-2329
DOI: 10.1503/cmaj.202604
PMID: 33741725
Source: ProQuest One Psychology
GFMER Free Medical Journals
MEDLINE
PubMed Central
Alma/SFX Local Collection
ProQuest Central
DOAJ Directory of Open Access Journals

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The impact of COVID-19 on pregnancy outcomes: a systematic review and meta-analysis

2021 CMA Joule Inc. or its licensors. ;COPYRIGHT 2021 Joule Inc. ;COPYRIGHT 2021 CMA Joule Inc. ;Copyright Joule Inc Apr 19, 2021 ;2021 CMA Joule Inc. or its licensors 2021 ;ISSN: 0820-3946 ;EISSN: 1488-2329 ;DOI: 10.1503/cmaj.202604 ;PMID: 33741725

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