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The epicardium as a hub for heart regeneration

Nature reviews cardiology, 2018-10, Vol.15 (10), p.631-647 [Peer Reviewed Journal]

COPYRIGHT 2018 Nature Publishing Group ;Copyright Nature Publishing Group Oct 2018 ;ISSN: 1759-5002 ;EISSN: 1759-5010 ;DOI: 10.1038/s41569-018-0046-4 ;PMID: 29950578

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Title:
The epicardium as a hub for heart regeneration
Author: Cao, Jingli ; Poss, Kenneth D
Subjects: Analysis ; Animals ; Cardiology ; Care and treatment ; Cell Differentiation ; Cell Lineage ; Cell Proliferation ; Cell Survival ; Disease Models, Animal ; Health aspects ; Heart ; Heart diseases ; Heart Diseases - metabolism ; Heart Diseases - pathology ; Heart Diseases - physiopathology ; Heart Diseases - therapy ; Heart muscle ; Humans ; Medical research ; Medicine, Experimental ; Mice, Transgenic ; Organogenesis ; Pericardium - metabolism ; Pericardium - pathology ; Pericardium - physiopathology ; Physiological aspects ; Recovery of Function ; Regeneration ; Regenerative medicine ; Regenerative Medicine - methods ; Signal Transduction ; Smooth muscle ; Tissue engineering
Is Part Of: Nature reviews cardiology, 2018-10, Vol.15 (10), p.631-647
Description: After decades of directed research, no effective regenerative therapy is currently available to repair the injured human heart. The epicardium, a layer of mesothelial tissue that envelops the heart in all vertebrates, has emerged as a new player in cardiac repair and regeneration. The epicardium is essential for muscle regeneration in the zebrafish model of innate heart regeneration, and the epicardium also participates in fibrotic responses in mammalian hearts. This structure serves as a source of crucial cells, such as vascular smooth muscle cells, pericytes, and fibroblasts, during heart development and repair. The epicardium also secretes factors that are essential for proliferation and survival of cardiomyocytes. In this Review, we describe recent advances in our understanding of the biology of the epicardium and the effect of these findings on the candidacy of this structure as a therapeutic target for heart repair and regeneration.
Publisher: England: Nature Publishing Group
Language: English
Identifier: ISSN: 1759-5002
EISSN: 1759-5010
DOI: 10.1038/s41569-018-0046-4
PMID: 29950578
Source: MEDLINE
ProQuest Central

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The epicardium as a hub for heart regeneration

COPYRIGHT 2018 Nature Publishing Group ;Copyright Nature Publishing Group Oct 2018 ;ISSN: 1759-5002 ;EISSN: 1759-5010 ;DOI: 10.1038/s41569-018-0046-4 ;PMID: 29950578

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