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Characteristics and clinical significance of myocardial injury in patients with severe coronavirus disease 2019

European Heart Journal, 2020-06, Vol.41 (22), p.2070-2079 [Peer Reviewed Journal]

Published on behalf of the European Society of Cardiology. All rights reserved. © The Author(s) 2020. For permissions, please email: journals.permissions@oup.com. 2020 ;Published on behalf of the European Society of Cardiology. All rights reserved. © The Author(s) 2020. For permissions, please email: journals.permissions@oup.com. ;2020. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the associated terms available at https://academic.oup.com/journals/pages/coronavirus . ;ISSN: 0195-668X ;EISSN: 1522-9645 ;DOI: 10.1093/eurheartj/ehaa408 ;PMID: 32391877

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Title:
Characteristics and clinical significance of myocardial injury in patients with severe coronavirus disease 2019
Author: Shi, Shaobo ; Qin, Mu ; Cai, Yuli ; Liu, Tao ; Shen, Bo ; Yang, Fan ; Cao, Sheng ; Liu, Xu ; Xiang, Yaozu ; Zhao, Qinyan ; Huang, He ; Yang, Bo ; Huang, Congxin
Subjects: Adult ; Aged ; Aged, 80 and over ; Betacoronavirus ; Biomarkers - blood ; China - epidemiology ; Coronavirus Infections - complications ; Coronavirus Infections - diagnosis ; Coronavirus Infections - mortality ; COVID-19 ; Fast Track Clinical Research ; Female ; Follow-Up Studies ; Heart Diseases - blood ; Heart Diseases - diagnosis ; Heart Diseases - mortality ; Heart Diseases - virology ; Hospital Mortality ; Humans ; Logistic Models ; Male ; Middle Aged ; Pandemics ; Pneumonia, Viral - complications ; Pneumonia, Viral - diagnosis ; Pneumonia, Viral - mortality ; Retrospective Studies ; Risk Factors ; SARS-CoV-2 ; Sensitivity and Specificity ; Severity of Illness Index
Is Part Of: European Heart Journal, 2020-06, Vol.41 (22), p.2070-2079
Description: Abstract Aims To investigate the characteristics and clinical significance of myocardial injury in patients with severe coronavirus disease 2019 (COVID-19). Methods and results We enrolled 671 eligible hospitalized patients with severe COVID-19 from 1 January to 23 February 2020, with a median age of 63 years. Clinical, laboratory, and treatment data were collected and compared between patients who died and survivors. Risk factors of death and myocardial injury were analysed using multivariable regression models. A total of 62 patients (9.2%) died, who more often had myocardial injury (75.8% vs. 9.7%; P < 0.001) than survivors. The area under the receiver operating characteristic curve of initial cardiac troponin I (cTnI) for predicting in-hospital mortality was 0.92 [95% confidence interval (CI), 0.87–0.96; sensitivity, 0.86; specificity, 0.86; P < 0.001]. The single cut-off point and high level of cTnI predicted risk of in-hospital death, hazard ratio (HR) was 4.56 (95% CI, 1.28–16.28; P = 0.019) and 1.25 (95% CI, 1.07–1.46; P = 0.004), respectively. In multivariable logistic regression, senior age, comorbidities (e.g. hypertension, coronary heart disease, chronic renal failure, and chronic obstructive pulmonary disease), and high level of C-reactive protein were predictors of myocardial injury. Conclusion The risk of in-hospital death among patients with severe COVID-19 can be predicted by markers of myocardial injury, and was significantly associated with senior age, inflammatory response, and cardiovascular comorbidities.
Publisher: England: Oxford University Press
Language: English
Identifier: ISSN: 0195-668X
EISSN: 1522-9645
DOI: 10.1093/eurheartj/ehaa408
PMID: 32391877
Source: Coronavirus Research Database

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Characteristics and clinical significance of myocardial injury in patients with severe coronavirus disease 2019

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