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Fundamental Mechanisms of Regulated Cell Death and Implications for Heart Disease

Physiological reviews, 2019-10, Vol.99 (4), p.1765-1817 [Peer Reviewed Journal]

Copyright American Physiological Society Jul 2019 ;Copyright American Physiological Society Oct 2019 ;Copyright © 2019 the American Physiological Society 2019 American Physiological Society ;ISSN: 0031-9333 ;EISSN: 1522-1210 ;DOI: 10.1152/physrev.00022.2018 ;PMID: 31364924

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Title:
Fundamental Mechanisms of Regulated Cell Death and Implications for Heart Disease
Author: Del Re, Dominic P ; Amgalan, Dulguun ; Linkermann, Andreas ; Liu, Qinghang ; Kitsis, Richard N
Subjects: Animals ; Apoptosis ; Apoptosis Regulatory Proteins - metabolism ; Autophagy ; Autophagy-Related Proteins - metabolism ; Cardiomyocytes ; Cardiovascular disease ; Cell Death ; Congestive heart failure ; Coronary artery disease ; Cytotoxicity, Immunologic ; Heart attacks ; Heart Diseases - immunology ; Heart Diseases - metabolism ; Heart Diseases - pathology ; Heart Diseases - physiopathology ; Heart failure ; Humans ; Immune checkpoint ; Immunogenicity ; Ischemia ; Mitochondria ; Mitochondria, Heart - immunology ; Mitochondria, Heart - metabolism ; Mitochondria, Heart - pathology ; Myocardial infarction ; Myocardium - immunology ; Myocardium - metabolism ; Myocardium - pathology ; Necroptosis ; Necrosis ; Phagocytosis ; Pyroptosis ; Reperfusion ; Review ; Signal Transduction
Is Part Of: Physiological reviews, 2019-10, Vol.99 (4), p.1765-1817
Description: Twelve regulated cell death programs have been described. We review in detail the basic biology of nine including death receptor-mediated apoptosis, death receptor-mediated necrosis (necroptosis), mitochondrial-mediated apoptosis, mitochondrial-mediated necrosis, autophagy-dependent cell death, ferroptosis, pyroptosis, parthanatos, and immunogenic cell death. This is followed by a dissection of the roles of these cell death programs in the major cardiac syndromes: myocardial infarction and heart failure. The most important conclusion relevant to heart disease is that regulated forms of cardiomyocyte death play important roles in both myocardial infarction with reperfusion (ischemia/reperfusion) and heart failure. While a role for apoptosis in ischemia/reperfusion cannot be excluded, regulated forms of necrosis, through both death receptor and mitochondrial pathways, are critical. Ferroptosis and parthanatos are also likely important in ischemia/reperfusion, although it is unclear if these entities are functioning as independent death programs or as amplification mechanisms for necrotic cell death. Pyroptosis may also contribute to ischemia/reperfusion injury, but potentially through effects in non-cardiomyocytes. Cardiomyocyte loss through apoptosis and necrosis is also an important component in the pathogenesis of heart failure and is mediated by both death receptor and mitochondrial signaling. Roles for immunogenic cell death in cardiac disease remain to be defined but merit study in this era of immune checkpoint cancer therapy. Biology-based approaches to inhibit cell death in the various cardiac syndromes are also discussed.
Publisher: United States: American Physiological Society
Language: English
Identifier: ISSN: 0031-9333
EISSN: 1522-1210
DOI: 10.1152/physrev.00022.2018
PMID: 31364924
Source: Freely Accessible Journals
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Fundamental Mechanisms of Regulated Cell Death and Implications for Heart Disease

Copyright American Physiological Society Jul 2019 ;Copyright American Physiological Society Oct 2019 ;Copyright © 2019 the American Physiological Society 2019 American Physiological Society ;ISSN: 0031-9333 ;EISSN: 1522-1210 ;DOI: 10.1152/physrev.00022.2018 ;PMID: 31364924

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