Language:

Use of mesenchymal stem cells for therapy of cardiac disease

Circulation research, 2015-04, Vol.116 (8), p.1413-1430 [Peer Reviewed Journal]

2015 American Heart Association, Inc. ;ISSN: 0009-7330 ;EISSN: 1524-4571 ;DOI: 10.1161/circresaha.116.303614 ;PMID: 25858066

Full text available

Citations Cited by

Actions
1. Add to My Research
2. Remove from My Research
3. E-mail
4. Print
5. Permalink
6. Citation
7. EasyBib
8. EndNote
9. RefWorks
10. Delicious
11. Export RIS
12. Export BibTeX

Title:
Use of mesenchymal stem cells for therapy of cardiac disease
Author: Karantalis, Vasileios ; Hare, Joshua M
Subjects: Animals ; Biomarkers - metabolism ; Cell Differentiation ; Cell Lineage ; Cell Proliferation ; Heart Diseases - metabolism ; Heart Diseases - pathology ; Heart Diseases - physiopathology ; Heart Diseases - surgery ; Humans ; Mesenchymal Stem Cell Transplantation - adverse effects ; Myocardium - metabolism ; Myocardium - pathology ; Phenotype ; Recovery of Function ; Regeneration ; Regenerative Medicine - methods ; Signal Transduction ; Treatment Outcome
Is Part Of: Circulation research, 2015-04, Vol.116 (8), p.1413-1430
Description: Despite substantial clinical advances over the past 65 years, cardiovascular disease remains the leading cause of death in America. The past 15 years has witnessed major basic and translational interest in the use of stem and precursor cells as a therapeutic agent for chronically injured organs. Among the cell types under investigation, adult mesenchymal stem cells are widely studied, and in early stage, clinical studies show promise for repair and regeneration of cardiac tissues. The ability of mesenchymal stem cells to differentiate into mesoderm- and nonmesoderm-derived tissues, their immunomodulatory effects, their availability, and their key role in maintaining and replenishing endogenous stem cell niches have rendered them one of the most heavily investigated and clinically tested type of stem cell. Accumulating data from preclinical and early phase clinical trials document their safety when delivered as either autologous or allogeneic forms in a range of cardiovascular diseases, but also importantly define parameters of clinical efficacy that justify further investigation in larger clinical trials. Here, we review the biology of mesenchymal stem cells, their interaction with endogenous molecular and cellular pathways, and their modulation of immune responses. Additionally, we discuss factors that enhance their proliferative and regenerative ability and factors that may hinder their effectiveness in the clinical setting.
Publisher: United States
Language: English
Identifier: ISSN: 0009-7330
EISSN: 1524-4571
DOI: 10.1161/circresaha.116.303614
PMID: 25858066
Source: GFMER Free Medical Journals
MEDLINE

Back to results list


INSPIRE LIBRARY - TON DUC THANG UNIVERSITY	(84-028) 37 755 057	Feedback
19 Nguyen Huu Tho St. Dist.7, HCM	thuvien@tdtu.edu.vn	Feedback

Use of mesenchymal stem cells for therapy of cardiac disease

2015 American Heart Association, Inc. ;ISSN: 0009-7330 ;EISSN: 1524-4571 ;DOI: 10.1161/circresaha.116.303614 ;PMID: 25858066

Searching Remote Databases, Please Wait