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Assessment of Echocardiography and Biomarkers for the Extended Prediction of Cardiotoxicity in Patients Treated With Anthracyclines, Taxanes, and Trastuzumab

Circulation. Cardiovascular imaging, 2012-09, Vol.5 (5), p.596-603 [Tạp chí có phản biện]

2015 INIST-CNRS ;ISSN: 1941-9651 ;EISSN: 1942-0080 ;DOI: 10.1161/CIRCIMAGING.112.973321 ;PMID: 22744937

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Nhan đề:
Assessment of Echocardiography and Biomarkers for the Extended Prediction of Cardiotoxicity in Patients Treated With Anthracyclines, Taxanes, and Trastuzumab
Tác giả: SAWAYA, Heloisa ; SEBAG, Igal A ; MARTIN, Randolph P ; PICARD, Michael H ; GERSZTEN, Robert E ; HALPERN, Elkan F ; PASSERI, Jonathan ; KUTER, Irene ; SCHERRER-CROSBIE, Marielle ; PLANA, Juan Carlos ; JANUZZI, James L ; KY, Bonnie ; TAN, Timothy C ; COHEN, Victor ; BANCHS, Jose ; CARVER, Joseph R ; WIEGERS, Susan E
Chủ đề: Adult ; Anthracyclines - administration & dosage ; Anthracyclines - adverse effects ; Antibodies, Monoclonal, Humanized - administration & dosage ; Antibodies, Monoclonal, Humanized - adverse effects ; Antineoplastic Combined Chemotherapy Protocols - adverse effects ; Biological and medical sciences ; Biomarkers - blood ; Breast Neoplasms - drug therapy ; Cardiology. Vascular system ; Cardiovascular system ; Chi-Square Distribution ; Echocardiography ; Female ; Gynecology. Andrology. Obstetrics ; Heart ; Heart Diseases - blood ; Heart Diseases - chemically induced ; Heart Diseases - diagnosis ; Heart Diseases - diagnostic imaging ; Heart Diseases - physiopathology ; Heart Diseases - prevention & control ; Heart failure, cardiogenic pulmonary edema, cardiac enlargement ; Humans ; Interleukin-1 Receptor-Like 1 Protein ; Investigative techniques of hemodynamics ; Investigative techniques, diagnostic techniques (general aspects) ; Logistic Models ; Mammary gland diseases ; Medical sciences ; Middle Aged ; Multivariate Analysis ; Myocardial Contraction - drug effects ; Natriuretic Peptide, Brain - blood ; North America ; Peptide Fragments - blood ; Predictive Value of Tests ; Prospective Studies ; Receptors, Cell Surface - blood ; Risk Assessment ; Risk Factors ; Stroke Volume - drug effects ; Taxoids - administration & dosage ; Taxoids - adverse effects ; Time Factors ; Trastuzumab ; Troponin I - blood ; Tumors ; Ultrasonic investigative techniques ; Ventricular Function, Left - drug effects
Là 1 phần của: Circulation. Cardiovascular imaging, 2012-09, Vol.5 (5), p.596-603
Mô tả: Because cancer patients survive longer, the impact of cardiotoxicity associated with the use of cancer treatments escalates. The present study investigates whether early alterations of myocardial strain and blood biomarkers predict incident cardiotoxicity in patients with breast cancer during treatment with anthracyclines, taxanes, and trastuzumab. Eighty-one women with newly diagnosed human epidermal growth factor receptor 2-positive breast cancer, treated with anthracyclines followed by taxanes and trastuzumab were enrolled to be evaluated every 3 months during their cancer therapy (total of 15 months) using echocardiograms and blood samples. Left ventricular ejection fraction, peak systolic longitudinal, radial, and circumferential myocardial strain were calculated. Ultrasensitive troponin I, N-terminal pro-B-type natriuretic peptide, and the interleukin family member (ST2) were also measured. Left ventricular ejection fraction decreased (64 ± 5% to 59 ± 6%; P<0.0001) over 15 months. Twenty-six patients (32%, [22%-43%]) developed cardiotoxicity as defined by the Cardiac Review and Evaluation Committee Reviewing Trastuzumab; of these patients, 5 (6%, [2%-14%]) had symptoms of heart failure. Peak systolic longitudinal myocardial strain and ultrasensitive troponin I measured at the completion of anthracyclines treatment predicted the subsequent development of cardiotoxicity; no significant associations were observed for left ventricular ejection fraction, N-terminal pro-B-type natriuretic peptide, and ST2. Longitudinal strain was <19% in all patients who later developed heart failure. In patients with breast cancer treated with anthracyclines, taxanes, and trastuzumab, systolic longitudinal myocardial strain and ultrasensitive troponin I measured at the completion of anthracyclines therapy are useful in the prediction of subsequent cardiotoxicity and may help guide treatment to avoid cardiac side-effects.
Nơi xuất bản: Hagerstown, MD: Lippincott Williams & Wilkins
Ngôn ngữ: English
Số nhận dạng: ISSN: 1941-9651
EISSN: 1942-0080
DOI: 10.1161/CIRCIMAGING.112.973321
PMID: 22744937
Nguồn: MEDLINE
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Assessment of Echocardiography and Biomarkers for the Extended Prediction of Cardiotoxicity in Patients Treated With Anthracyclines, Taxanes, and Trastuzumab

2015 INIST-CNRS ;ISSN: 1941-9651 ;EISSN: 1942-0080 ;DOI: 10.1161/CIRCIMAGING.112.973321 ;PMID: 22744937

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