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Calcium Signaling and Transcriptional Regulation in Cardiomyocytes

Circulation research, 2017-09, Vol.121 (8), p.1000-1020 [Peer Reviewed Journal]

2017 American Heart Association, Inc. ;Copyright Lippincott Williams & Wilkins Ovid Technologies Sep 29, 2017 ;ISSN: 0009-7330 ;EISSN: 1524-4571 ;DOI: 10.1161/CIRCRESAHA.117.310355 ;PMID: 28963192

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Title:
Calcium Signaling and Transcriptional Regulation in Cardiomyocytes
Author: Dewenter, Matthias ; von der Lieth, Albert ; Katus, Hugo A ; Backs, Johannes
Subjects: Animals ; Calcium Signaling - drug effects ; Calcium signalling ; Cardiomyocytes ; Cardiovascular Agents - therapeutic use ; Cell Nucleus - metabolism ; Contraction ; Coronary artery disease ; Cytosol - metabolism ; Excitation Contraction Coupling ; Gene expression ; Gene Expression Regulation ; Gene regulation ; Heart diseases ; Heart Diseases - drug therapy ; Heart Diseases - genetics ; Heart Diseases - metabolism ; Heart Diseases - physiopathology ; Humans ; Kinetics ; Myocardial Contraction ; Myocytes, Cardiac - drug effects ; Myocytes, Cardiac - metabolism ; Signal transduction ; Structure-function relationships ; Transcription ; Transcription, Genetic - drug effects
Is Part Of: Circulation research, 2017-09, Vol.121 (8), p.1000-1020
Description: Calcium (Ca) is a universal regulator of various cellular functions. In cardiomyocytes, Ca is the central element of excitation–contraction coupling, but also impacts diverse signaling cascades and influences the regulation of gene expression, referred to as excitation–transcription coupling. Disturbances in cellular Ca-handling and alterations in Ca-dependent gene expression patterns are pivotal characteristics of failing cardiomyocytes, with several excitation–transcription coupling pathways shown to be critically involved in structural and functional remodeling processes. Thus, targeting Ca-dependent transcriptional pathways might offer broad therapeutic potential. In this article, we (1) review cytosolic and nuclear Ca dynamics in cardiomyocytes with respect to their impact on Ca-dependent signaling, (2) give an overview on Ca-dependent transcriptional pathways in cardiomyocytes, and (3) discuss implications of excitation–transcription coupling in the diseased heart.
Publisher: United States: American Heart Association, Inc
Language: English
Identifier: ISSN: 0009-7330
EISSN: 1524-4571
DOI: 10.1161/CIRCRESAHA.117.310355
PMID: 28963192
Source: GFMER Free Medical Journals
MEDLINE

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Calcium Signaling and Transcriptional Regulation in Cardiomyocytes

2017 American Heart Association, Inc. ;Copyright Lippincott Williams & Wilkins Ovid Technologies Sep 29, 2017 ;ISSN: 0009-7330 ;EISSN: 1524-4571 ;DOI: 10.1161/CIRCRESAHA.117.310355 ;PMID: 28963192

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