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Loss of β-catenin in resident cardiac fibroblasts attenuates fibrosis induced by pressure overload in mice

Nature communications, 2017-09, Vol.8 (1), p.712-12, Article 712 [Peer Reviewed Journal]

2017. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. ;The Author(s) 2017 ;ISSN: 2041-1723 ;EISSN: 2041-1723 ;DOI: 10.1038/s41467-017-00840-w ;PMID: 28959037

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Title:
Loss of β-catenin in resident cardiac fibroblasts attenuates fibrosis induced by pressure overload in mice
Author: Xiang, Fu-Li ; Fang, Ming ; Yutzey, Katherine E
Subjects: Animals ; Aorta ; Aorta - metabolism ; Aorta - physiopathology ; Basic Helix-Loop-Helix Transcription Factors - genetics ; Basic Helix-Loop-Helix Transcription Factors - metabolism ; beta Catenin - genetics ; beta Catenin - metabolism ; Cardiomyocytes ; Cardiovascular diseases ; Collagen ; Collagen - metabolism ; Constrictions ; Coronary artery disease ; Deposition ; Extracellular matrix ; Extracellular Matrix - genetics ; Extracellular Matrix - metabolism ; Female ; Fibroblasts ; Fibroblasts - metabolism ; Fibroblasts - pathology ; Fibrosis ; Fibrosis - genetics ; Fibrosis - metabolism ; Fibrosis - pathology ; Fibrosis - physiopathology ; Gene expression ; Gene sequencing ; Heart ; Heart - physiopathology ; Heart diseases ; Heart Diseases - genetics ; Heart Diseases - metabolism ; Heart Diseases - pathology ; Heart Diseases - physiopathology ; Humans ; Hypertrophy ; Male ; Mice ; Mice, Knockout ; Pressure ; Rodents ; Wnt protein ; Wnt Signaling Pathway ; β-Catenin
Is Part Of: Nature communications, 2017-09, Vol.8 (1), p.712-12, Article 712
Description: Cardiac fibrosis is characterized by excessive extracellular matrix deposition that contributes to compromised cardiac function and potentially heart failure. Cardiac pressure overload resulting from trans-aortic constriction in mice leads to cardiac fibrosis and increased Wnt/β-catenin signaling in cardiac fibroblasts. Here, we conditionally induce β-catenin loss of function in resident cardiac fibroblasts using Tcf21 or in activated cardiac fibroblasts using periostin (Postn) . We show that β-catenin loss of function in cardiac fibroblasts after trans-aortic constriction significantly preserves cardiac function, and reduces interstitial fibrosis but does not alter the numbers of activated or differentiated cardiac fibroblasts in vivo. However, β-catenin is specifically required in resident cardiac fibroblasts for fibrotic excessive extracellular matrix gene expression and binds Col3a1 and Postn gene sequences in cultured cardiac fibroblasts after induction of Wnt signaling. Moreover, cardiomyocyte hypertrophy is blunted with cardiac fibroblast-specific loss of β-catenin after trans-aortic constriction in vivo. Thus, Wnt/β-catenin signaling in resident cardiac fibroblasts is required for excessive extracellular matrix gene expression and collagen deposition after trans-aortic constriction.Understanding the mechanisms causing cardiac fibrosis is key to prevention and therapy development of many heart diseases. Here, the authors show that Wnt/β-catenin signaling in resident cardiac fibroblasts is required for deposition of fibrotic extracellular matrix and the regulation of cardiomyocyte hypertrophy in a mouse model of heart fibrosis.
Publisher: England: Nature Publishing Group
Language: English
Identifier: ISSN: 2041-1723
EISSN: 2041-1723
DOI: 10.1038/s41467-017-00840-w
PMID: 28959037
Source: MEDLINE
PubMed Central
ProQuest Central
DOAJ Directory of Open Access Journals

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Loss of β-catenin in resident cardiac fibroblasts attenuates fibrosis induced by pressure overload in mice

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