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Environmental Risk Factors for Congenital Heart Disease

Cold Spring Harbor perspectives in biology, 2020-03, Vol.12 (3), p.1 [Tạp chí có phản biện]

Copyright © 2020 Cold Spring Harbor Laboratory Press; all rights reserved. ;Copyright Cold Spring Harbor Laboratory Press Mar 2020 ;2020 ;EISSN: 1943-0264 ;DOI: 10.1101/cshperspect.a037234 ;PMID: 31548181

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Nhan đề:
Environmental Risk Factors for Congenital Heart Disease
Tác giả: Kalisch-Smith, Jacinta Isabelle ; Ved, Nikita ; Sparrow, Duncan Burnaby
Chủ đề: Alcohol Drinking ; Animals ; Cardiovascular disease ; Cardiovascular diseases ; Congenital diseases ; Coronary artery disease ; Diabetes Mellitus - drug therapy ; Environmental Exposure ; Environmental factors ; Environmental risk ; Gene-Environment Interaction ; Genomics ; Health risk assessment ; Heart - embryology ; Heart Defects, Congenital - etiology ; Heart diseases ; Humans ; Hyperthermia ; Hypoxia ; Identification methods ; Molecular modelling ; Obesity - drug therapy ; PERSPECTIVES ; Phenylketonurias - drug therapy ; Prevalence ; Public health ; Risk analysis ; Risk Factors ; Thalidomide ; Tretinoin - adverse effects ; Vitamin A - adverse effects
Là 1 phần của: Cold Spring Harbor perspectives in biology, 2020-03, Vol.12 (3), p.1
Mô tả: Congenital heart disease (CHD) has many forms and a wide range of causes. Clinically, it is important to understand the causes. This allows estimation of recurrence rate, guides treatment options, and may also be used to formulate public health advice to reduce the population prevalence of CHD. The recent advent of sophisticated genetic and genomic methods has led to the identification of more than 100 genes associated with CHD. However, despite these great strides, to date only one-third of CHD cases have been shown to have a simple genetic cause. This is because CHD can also be caused by oligogenic factors, environmental factors, and/or gene-environment interaction. Although solid evidence for environmental causes of CHD have been available for almost 80 years, it is only very recently that the molecular mechanisms for these risk factors have begun to be investigated. In this review, we describe the most important environmental CHD risk factors, and what is known about how they cause CHD.
Nơi xuất bản: United States: Cold Spring Harbor Laboratory Press
Ngôn ngữ: English
Số nhận dạng: EISSN: 1943-0264
DOI: 10.1101/cshperspect.a037234
PMID: 31548181
Nguồn: GFMER Free Medical Journals
MEDLINE
PubMed Central
Alma/SFX Local Collection

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Environmental Risk Factors for Congenital Heart Disease

Copyright © 2020 Cold Spring Harbor Laboratory Press; all rights reserved. ;Copyright Cold Spring Harbor Laboratory Press Mar 2020 ;2020 ;EISSN: 1943-0264 ;DOI: 10.1101/cshperspect.a037234 ;PMID: 31548181

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