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Congenital heart defects and intensity of oil and gas well site activities in early pregnancy

Environment international, 2019-11, Vol.132, p.104949, Article 104949 [Peer Reviewed Journal]

2019 The Authors ;Copyright © 2019 The Authors. Published by Elsevier Ltd.. All rights reserved. ;ISSN: 0160-4120 ;EISSN: 1873-6750 ;DOI: 10.1016/j.envint.2019.104949 ;PMID: 31327466

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  • Title:
    Congenital heart defects and intensity of oil and gas well site activities in early pregnancy
  • Author: McKenzie, Lisa M. ; Allshouse, William ; Daniels, Stephen
  • Subjects: Adult ; Air Pollution - adverse effects ; Birth outcomes ; Case control study ; Case-Control Studies ; Colorado ; Congenital heart defects ; Environmental exposure ; Female ; Heart Defects, Congenital - etiology ; Humans ; Hydraulic fracturing ; Infant ; Infant, Newborn ; Logistic Models ; Male ; Maternal Exposure ; Oil and Gas Fields ; Oil and natural gas development ; Pregnancy ; Risk Factors
  • Is Part Of: Environment international, 2019-11, Vol.132, p.104949, Article 104949
  • Description: Preliminary studies suggest that offspring to mothers living near oil and natural gas (O&G) well sites are at higher risk of congenital heart defects (CHDs). Our objective was to address the limitations of previous studies in a new and more robust evaluation of the relationship between maternal proximity to O&G well site activities and births with CHDs. We employed a nested case-control study of 3324 infants born in Colorado between 2005 and 2011. 187, 179, 132, and 38 singleton births with an aortic artery and valve (AAVD), pulmonary artery and valve (PAVD), conotruncal (CTD), or tricuspid valve (TVD) defect, respectively, were frequency matched 1:5 to controls on sex, maternal smoking, and race and ethnicity yielding 2860 controls. We estimated monthly intensities of O&G activity at maternal residences from three months prior to conception through the second gestational month with our intensity adjusted inverse distance weighted model. We used logistic regression models adjusted for O&G facilities other than wells, intensity of air pollution sources not associated with O&G activities, maternal age and socioeconomic status index, and infant sex and parity, to evaluate associations between CHDs and O&G activity intensity groups (low, medium, and high). Overall, CHDs were 1.4 (1.0, 2.0) and 1.7 (1.1, 2.6) times more likely than controls in the medium and high intensity groups, respectively, compared to the low intensity group. PAVDs were 1.7 (0.93, 3.0) and 2.5 (1.1, 5.3) times more likely in the medium and high intensity groups for mothers with an address found in the second gestational month. In rural areas, AAVDs, CTDs, and TVDs were 1.8 (0.97, 3.3) and 2.6 (1.1, 6.1); 2.1 (0.96, 4.5) and 4.0 (1.4, 12); and 3.4 (0.95, 12) and 4.6 (0.81, 26) times more likely than controls in the medium and high intensity groups. This study provides further evidence of a positive association between maternal proximity to O&G well site activities and several types of CHDs, particularly in rural areas. •Higher pulmonary artery and valve defect prevalence in oil and gas activity area•Congenital heart defect prevalence highest in rural areas with oil and gas activity•Higher aortic artery and valve defect prevalence in rural oil and gas activity area•Higher conotruncal defect prevalence in rural oil and gas activity area•Higher tricuspid valve defect prevalence in rural oil and gas activity area
  • Publisher: Netherlands: Elsevier Ltd
  • Language: English
  • Identifier: ISSN: 0160-4120
    EISSN: 1873-6750
    DOI: 10.1016/j.envint.2019.104949
    PMID: 31327466
  • Source: MEDLINE
    DOAJ Directory of Open Access Journals
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