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Differential Cytotoxicity of Curcumin-Loaded Micelles on Human Tumor and Stromal Cells

International journal of molecular sciences, 2022-10, Vol.23 (20), p.12362 [Tạp chí có phản biện]

2022 by the authors. 2022 ;ISSN: 1422-0067 ;ISSN: 1661-6596 ;EISSN: 1422-0067 ;DOI: 10.3390/ijms232012362 ;PMID: 36293215

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  • Nhan đề:
    Differential Cytotoxicity of Curcumin-Loaded Micelles on Human Tumor and Stromal Cells
  • Tác giả: Do, Xuan-Hai ; Hoang, My Hanh Thi ; Vu, Anh-Tuan ; Nguyen, Lai-Thanh ; Bui, Dung Thi Thuy ; Dinh, Duy-Thanh ; Nguyen, Xuan-Hung ; Than, Uyen Thi Trang ; Mai, Hien Thi ; To, Thuy Thanh ; Nguyen, Tra Ngoc Huong ; Hoang, Nhung Thi My
  • Chủ đề: Breast cancer ; Curcumin ; Human health sciences ; Micelle ; nano-cytotoxicity ; Nanotoxicity ; Pharmacie, pharmacologie & toxicologie ; Pharmacy, pharmacology & toxicology ; Sciences de la santé humaine ; Tumor spheroids ; Zebrafish
  • Là 1 phần của: International journal of molecular sciences, 2022-10, Vol.23 (20), p.12362
  • Mô tả: Although curcumin in the form of nanoparticles has been demonstrated as a potential anti-tumor compound, the impact of curcumin and nanocurcumin in vitro on normal cells and in vivo in animal models is largely unknown. This study evaluated the toxicity of curcumin-loaded micelles in vitro and in vivo on several tumor cell lines, primary stromal cells, and zebrafish embryos. Breast tumor cell line (MCF7) and stromal cells (human umbilical cord vein endothelial cells, human fibroblasts, and human umbilical cord-derived mesenchymal stem cells) were used in this study. A zebrafish embryotoxicity (FET) assay was conducted following the Organisation for Economic Co-operation and Development (OECD) Test 236. Compared to free curcumin, curcumin PM showed higher cytotoxicity to MCF7 cells in both monolayer culture and multicellular tumor spheroids. The curcumin-loaded micelles efficiently penetrated the MCF7 spheroids and induced apoptosis. The nanocurcumin reduced the viability and disturbed the function of stromal cells by suppressing cell migration and tube formation. The micelles demonstrated toxicity to the development of zebrafish embryos. Curcumin-loaded micelles demonstrated toxicity to both tumor and normal primary stromal cells and zebrafish embryos, indicating that the use of nanocurcumin in cancer treatment should be carefully investigated and controlled.
  • Nơi xuất bản: MDPI AG
  • Ngôn ngữ: English
  • Số nhận dạng: ISSN: 1422-0067
    ISSN: 1661-6596
    EISSN: 1422-0067
    DOI: 10.3390/ijms232012362
    PMID: 36293215
  • Nguồn: PubMed Central
    ProQuest Central
    DOAJ Directory of Open Access Journals
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