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1
Effect of Sulfotyrosine and Negatively Charged Amino Acid of Leech‐Derived Peptides on Binding and Inhibitory Activity Against Thrombin
Effect of Sulfotyrosine and Negatively Charged Amino Acid of Leech‐Derived Peptides on Binding and Inhibitory Activity Against Thrombin
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Effect of Sulfotyrosine and Negatively Charged Amino Acid of Leech‐Derived Peptides on Binding and Inhibitory Activity Against Thrombin

Chembiochem : a European journal of chemical biology, 2024-02, Vol.25 (3) [Peer Reviewed Journal]

ISSN: 1439-4227 ;ISSN: 1439-7633 ;EISSN: 1439-7633 ;DOI: 10.1002/cbic.202300744

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2
Targeting endothelial coagulation signaling ameliorates liver obstructive cholestasis and dysfunctional angiogenesis
Targeting endothelial coagulation signaling ameliorates liver obstructive cholestasis and dysfunctional angiogenesis
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Targeting endothelial coagulation signaling ameliorates liver obstructive cholestasis and dysfunctional angiogenesis

Experimental biology and medicine (Maywood, N.J.), 2023-07, Vol.248 (14), p.1242-1253 [Peer Reviewed Journal]

2023 by the Society for Experimental Biology and Medicine ;2023 by the Society for Experimental Biology and Medicine 2023 The Society for Experimental Biology and Medicine ;ISSN: 1535-3702 ;EISSN: 1535-3699 ;DOI: 10.1177/15353702231191190 ;PMID: 37644866

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3
Draft genome of the European medicinal leech Hirudo medicinalis (Annelida, Clitellata, Hirudiniformes) with emphasis on anticoagulants
Draft genome of the European medicinal leech Hirudo medicinalis (Annelida, Clitellata, Hirudiniformes) with emphasis on anticoagulants
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Draft genome of the European medicinal leech Hirudo medicinalis (Annelida, Clitellata, Hirudiniformes) with emphasis on anticoagulants

Scientific reports, 2020-06, Vol.10 (1), p.9885-9885, Article 9885 [Peer Reviewed Journal]

The Author(s) 2020. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. ;The Author(s) 2020 ;ISSN: 2045-2322 ;EISSN: 2045-2322 ;DOI: 10.1038/s41598-020-66749-5 ;PMID: 32555498

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4
Hirudin Reduces the Expression of Markers of the Extracellular Matrix in Renal Tubular Epithelial Cells in a Rat Model of Diabetic Kidney Disease Through the Hypoxia-Inducible Factor-1α (HIF-1α)/Vascular Endothelial Growth Factor (VEGF) Signaling Pathway
Hirudin Reduces the Expression of Markers of the Extracellular Matrix in Renal Tubular Epithelial Cells in a Rat Model of Diabetic Kidney Disease Through the Hypoxia-Inducible Factor-1α (HIF-1α)/Vascular Endothelial Growth Factor (VEGF) Signaling Pathway
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Hirudin Reduces the Expression of Markers of the Extracellular Matrix in Renal Tubular Epithelial Cells in a Rat Model of Diabetic Kidney Disease Through the Hypoxia-Inducible Factor-1α (HIF-1α)/Vascular Endothelial Growth Factor (VEGF) Signaling Pathway

Medical science monitor, 2020-05, Vol.26, p.e921894-e921894

Med Sci Monit, 2020 2020 ;ISSN: 1643-3750 ;ISSN: 1234-1010 ;EISSN: 1643-3750 ;DOI: 10.12659/MSM.921894 ;PMID: 32473006

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5
The hirudin-like factors HLF3 and HLF4—hidden hirudins of European medicinal leeches
The hirudin-like factors HLF3 and HLF4—hidden hirudins of European medicinal leeches
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The hirudin-like factors HLF3 and HLF4—hidden hirudins of European medicinal leeches

Parasitology research (1987), 2020-06, Vol.119 (6), p.1767-1775 [Peer Reviewed Journal]

The Author(s) 2020 ;ISSN: 0932-0113 ;EISSN: 1432-1955 ;DOI: 10.1007/s00436-020-06697-1

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6
Thrombomodulin is a determinant of metastasis through a mechanism linked to the thrombin binding domain but not the lectin-like domain
Thrombomodulin is a determinant of metastasis through a mechanism linked to the thrombin binding domain but not the lectin-like domain
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Thrombomodulin is a determinant of metastasis through a mechanism linked to the thrombin binding domain but not the lectin-like domain

Blood, 2011-09, Vol.118 (10), p.2889-2895 [Peer Reviewed Journal]

2011 American Society of Hematology ;2015 INIST-CNRS ;2011 by The American Society of Hematology 2011 ;ISSN: 0006-4971 ;EISSN: 1528-0020 ;DOI: 10.1182/blood-2011-03-341222 ;PMID: 21788337

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7
Exploring the mechanism of hirudin in the treatment of diabetic kidney disease using network pharmacology combined with molecular docking verification
Exploring the mechanism of hirudin in the treatment of diabetic kidney disease using network pharmacology combined with molecular docking verification
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Exploring the mechanism of hirudin in the treatment of diabetic kidney disease using network pharmacology combined with molecular docking verification

Journal of traditional Chinese medicine, 2022-08, Vol.42 (4), p.586-594 [Peer Reviewed Journal]

2022 JTCM. All rights reserved. 2022 Editorial board of Journal of Traditional Chinese Medicine ;ISSN: 0255-2922 ;EISSN: 2589-451X ;DOI: 10.19852/j.cnki.jtcm.2022.04.004 ;PMID: 35848975

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8
Be ready at any time: postprandial synthesis of salivary proteins in salivary gland cells of the haematophagous leech Hirudo verbana
Be ready at any time: postprandial synthesis of salivary proteins in salivary gland cells of the haematophagous leech Hirudo verbana
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Be ready at any time: postprandial synthesis of salivary proteins in salivary gland cells of the haematophagous leech Hirudo verbana

Journal of experimental biology, 2016-04, Vol.219 (Pt 8), p.1139-1145 [Peer Reviewed Journal]

2016. Published by The Company of Biologists Ltd. ;ISSN: 0022-0949 ;EISSN: 1477-9145 ;DOI: 10.1242/jeb.135509 ;PMID: 27103675

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9
Endothelial cell-specific anticoagulation reduces inflammation in a mouse model of acute lung injury
Endothelial cell-specific anticoagulation reduces inflammation in a mouse model of acute lung injury
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Endothelial cell-specific anticoagulation reduces inflammation in a mouse model of acute lung injury

Acta pharmacologica Sinica, 2019-06, Vol.40 (6), p.769-780 [Peer Reviewed Journal]

Copyright Nature Publishing Group Jun 2019 ;Shanghai Institute of Materia Medica, CAS and Chinese Pharmacological Society. All rights reserved 2018 ;ISSN: 1671-4083 ;EISSN: 1745-7254 ;DOI: 10.1038/s41401-018-0175-7 ;PMID: 30446733

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10
G-Quadruplex Aptamers to Human Thrombin Versus Other Direct Thrombin Inhibitors: The Focus on Mechanism of Action and Drug Efficiency as Anticoagulants
G-Quadruplex Aptamers to Human Thrombin Versus Other Direct Thrombin Inhibitors: The Focus on Mechanism of Action and Drug Efficiency as Anticoagulants
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G-Quadruplex Aptamers to Human Thrombin Versus Other Direct Thrombin Inhibitors: The Focus on Mechanism of Action and Drug Efficiency as Anticoagulants

Current medicinal chemistry, 2016-01, Vol.23 (21), p.2230-2244 [Peer Reviewed Journal]

Copyright Bentham Science Publishers Ltd. Jun 2016 ;ISSN: 0929-8673 ;EISSN: 1875-533X ;DOI: 10.2174/0929867323666160517120126 ;PMID: 27183984

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11
Revisiting antithrombotic therapeutics; sculptin, a novel specific, competitive, reversible, scissile and tight binding inhibitor of thrombin
Revisiting antithrombotic therapeutics; sculptin, a novel specific, competitive, reversible, scissile and tight binding inhibitor of thrombin
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Revisiting antithrombotic therapeutics; sculptin, a novel specific, competitive, reversible, scissile and tight binding inhibitor of thrombin

Scientific reports, 2017-05, Vol.7 (1), p.1431-14, Article 1431 [Peer Reviewed Journal]

Copyright Nature Publishing Group May 2017 ;The Author(s) 2017 ;ISSN: 2045-2322 ;EISSN: 2045-2322 ;DOI: 10.1038/s41598-017-01486-w ;PMID: 28469161

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12
Crystal structure of thrombin in complex with S-variegin: insights of a novel mechanism of inhibition and design of tunable thrombin inhibitors
Crystal structure of thrombin in complex with S-variegin: insights of a novel mechanism of inhibition and design of tunable thrombin inhibitors
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Crystal structure of thrombin in complex with S-variegin: insights of a novel mechanism of inhibition and design of tunable thrombin inhibitors

PloS one, 2011-10, Vol.6 (10), p.e26367-e26367 [Peer Reviewed Journal]

COPYRIGHT 2011 Public Library of Science ;COPYRIGHT 2011 Public Library of Science ;2011 Koh et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: https://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. ;Koh et al. 2011 ;ISSN: 1932-6203 ;EISSN: 1932-6203 ;DOI: 10.1371/journal.pone.0026367 ;PMID: 22053189

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13
Transcriptomic Analysis of the Influence of Methanol Assimilation on the Gene Expression in the Recombinant Pichia pastoris Producing Hirudin Variant 3
Transcriptomic Analysis of the Influence of Methanol Assimilation on the Gene Expression in the Recombinant Pichia pastoris Producing Hirudin Variant 3
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Transcriptomic Analysis of the Influence of Methanol Assimilation on the Gene Expression in the Recombinant Pichia pastoris Producing Hirudin Variant 3

Genes, 2019-08, Vol.10 (8), p.606 [Peer Reviewed Journal]

2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. ;2019 by the authors. 2019 ;ISSN: 2073-4425 ;EISSN: 2073-4425 ;DOI: 10.3390/genes10080606 ;PMID: 31409011

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14
Effects of Thrombin on Neurogenesis After Intracerebral Hemorrhage
Effects of Thrombin on Neurogenesis After Intracerebral Hemorrhage
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Effects of Thrombin on Neurogenesis After Intracerebral Hemorrhage

Stroke (1970), 2008-07, Vol.39 (7), p.2079-2084 [Peer Reviewed Journal]

2008 INIST-CNRS ;ISSN: 0039-2499 ;EISSN: 1524-4628 ;DOI: 10.1161/STROKEAHA.107.508911 ;PMID: 18436875 ;CODEN: SJCCA7

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15
Blood protein-polymer adsorption: Implications for understanding complement-mediated hemoincompatibility
Blood protein-polymer adsorption: Implications for understanding complement-mediated hemoincompatibility
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Blood protein-polymer adsorption: Implications for understanding complement-mediated hemoincompatibility

Journal of biomedical materials research. Part A, 2011-04, Vol.97A (1), p.74-84 [Peer Reviewed Journal]

Copyright © 2011 Wiley Periodicals, Inc. ;2015 INIST-CNRS ;ISSN: 1549-3296 ;ISSN: 1552-4965 ;EISSN: 1552-4965 ;DOI: 10.1002/jbm.a.33030 ;PMID: 21319295

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16
Polyphosphate binds with high affinity to exosite II of thrombin
Polyphosphate binds with high affinity to exosite II of thrombin
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Polyphosphate binds with high affinity to exosite II of thrombin

Journal of thrombosis and haemostasis, 2010-03, Vol.8 (3), p.548-555 [Peer Reviewed Journal]

2009 International Society on Thrombosis and Haemostasis ;ISSN: 1538-7933 ;ISSN: 1538-7836 ;EISSN: 1538-7836 ;DOI: 10.1111/j.1538-7836.2009.03723.x ;PMID: 20002544

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17
Soluble Expression of a Human MnSOD and Hirudin Fusion Protein in Escherichia coli, and Its Effects on Metastasis and Invasion of 95-D Cells
Soluble Expression of a Human MnSOD and Hirudin Fusion Protein in Escherichia coli, and Its Effects on Metastasis and Invasion of 95-D Cells
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Soluble Expression of a Human MnSOD and Hirudin Fusion Protein in Escherichia coli, and Its Effects on Metastasis and Invasion of 95-D Cells

Journal of Microbiology and Biotechnology, 2016, 26(11), , pp.1881-1890 [Peer Reviewed Journal]

ISSN: 1017-7825 ;EISSN: 1738-8872 ;DOI: 10.4014/jmb.1603.03070

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18
Structural and Functional Characterization of Hirudin P6 Derived Novel Bivalent Thrombin Inhibitors - Studying the Effect of Linker Length and Glycosylation on Their Function
Structural and Functional Characterization of Hirudin P6 Derived Novel Bivalent Thrombin Inhibitors - Studying the Effect of Linker Length and Glycosylation on Their Function
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Structural and Functional Characterization of Hirudin P6 Derived Novel Bivalent Thrombin Inhibitors - Studying the Effect of Linker Length and Glycosylation on Their Function

Chemical biology & drug design, 2016-07, Vol.88 (1), p.129-141 [Peer Reviewed Journal]

2016 John Wiley & Sons A/S ;2016 John Wiley & Sons A/S. ;ISSN: 1747-0277 ;EISSN: 1747-0285 ;DOI: 10.1111/cbdd.12742 ;PMID: 26850929

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19
Effect of thrombin inhibitors on positive feedback in the coagulation cascade
Effect of thrombin inhibitors on positive feedback in the coagulation cascade
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Effect of thrombin inhibitors on positive feedback in the coagulation cascade

Biochemistry (Moscow), 2016-03, Vol.81 (3), p.242-248 [Peer Reviewed Journal]

Pleiades Publishing, Ltd. 2016 ;COPYRIGHT 2016 Springer ;ISSN: 0006-2979 ;EISSN: 1608-3040 ;DOI: 10.1134/S0006297916030068 ;PMID: 27262193

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20
HD1, a Thrombin-directed Aptamer, Binds Exosite 1 on Prothrombin with High Affinity and Inhibits Its Activation by Prothrombinase
HD1, a Thrombin-directed Aptamer, Binds Exosite 1 on Prothrombin with High Affinity and Inhibits Its Activation by Prothrombinase
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HD1, a Thrombin-directed Aptamer, Binds Exosite 1 on Prothrombin with High Affinity and Inhibits Its Activation by Prothrombinase

The Journal of biological chemistry, 2006-12, Vol.281 (49), p.37477-37485 [Peer Reviewed Journal]

2006 © 2006 ASBMB. Currently published by Elsevier Inc; originally published by American Society for Biochemistry and Molecular Biology. ;ISSN: 0021-9258 ;EISSN: 1083-351X ;DOI: 10.1074/jbc.M607359200 ;PMID: 17046833

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