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1
Cerebral Cavernous Malformation: From Mechanism to Therapy
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Cerebral Cavernous Malformation: From Mechanism to Therapy

Circulation research, 2021-06, Vol.129 (1), p.195-215 [Peer Reviewed Journal]

ISSN: 0009-7330 ;EISSN: 1524-4571 ;DOI: 10.1161/circresaha.121.318174 ;PMID: 34166073

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2
PIK3CA and CCM mutations fuel cavernomas through a cancer-like mechanism
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PIK3CA and CCM mutations fuel cavernomas through a cancer-like mechanism

Nature (London), 2021-06, Vol.594 (7862), p.271-276 [Peer Reviewed Journal]

COPYRIGHT 2021 Nature Publishing Group ;Copyright Nature Publishing Group Jun 10, 2021 ;ISSN: 0028-0836 ;EISSN: 1476-4687 ;DOI: 10.1038/s41586-021-03562-8 ;PMID: 33910229

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3
Cerebral cavernous malformations arise from endothelial gain of MEKK3-KLF2/4 signalling
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Cerebral cavernous malformations arise from endothelial gain of MEKK3-KLF2/4 signalling

Nature (London), 2016-04, Vol.532 (7597), p.122-126 [Peer Reviewed Journal]

COPYRIGHT 2016 Nature Publishing Group ;COPYRIGHT 2016 Nature Publishing Group ;Copyright Nature Publishing Group Apr 7, 2016 ;ISSN: 0028-0836 ;EISSN: 1476-4687 ;DOI: 10.1038/nature17178 ;PMID: 27027284 ;CODEN: NATUAS

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4
Endothelial TLR4 and the microbiome drive cerebral cavernous malformations
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Endothelial TLR4 and the microbiome drive cerebral cavernous malformations

Nature (London), 2017-05, Vol.545 (7654), p.305-310 [Peer Reviewed Journal]

COPYRIGHT 2017 Nature Publishing Group ;COPYRIGHT 2017 Nature Publishing Group ;Copyright Nature Publishing Group May 18, 2017 ;ISSN: 0028-0836 ;EISSN: 1476-4687 ;DOI: 10.1038/nature22075 ;PMID: 28489816

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5
EndMT contributes to the onset and progression of cerebral cavernous malformations
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EndMT contributes to the onset and progression of cerebral cavernous malformations

Nature (London), 2013-06, Vol.498 (7455), p.492-496 [Peer Reviewed Journal]

COPYRIGHT 2013 Nature Publishing Group ;COPYRIGHT 2013 Nature Publishing Group ;Copyright Nature Publishing Group Jun 27, 2013 ;ISSN: 0028-0836 ;EISSN: 1476-4687 ;DOI: 10.1038/nature12207 ;PMID: 23748444 ;CODEN: NATUAS

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6
Neuroinflammation Plays a Critical Role in Cerebral Cavernous Malformation Disease
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Neuroinflammation Plays a Critical Role in Cerebral Cavernous Malformation Disease

Circulation research, 2022-11, Vol.131 (11), p.909-925 [Peer Reviewed Journal]

ISSN: 0009-7330 ;EISSN: 1524-4571 ;DOI: 10.1161/CIRCRESAHA.122.321129 ;PMID: 36285625

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7
Lesions from patients with sporadic cerebral cavernous malformations harbor somatic mutations in the CCM genes: evidence for a common biochemical pathway for CCM pathogenesis
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Lesions from patients with sporadic cerebral cavernous malformations harbor somatic mutations in the CCM genes: evidence for a common biochemical pathway for CCM pathogenesis

Human molecular genetics, 2014-08, Vol.23 (16), p.4357-4370 [Peer Reviewed Journal]

The Author 2014. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com. ;The Author 2014. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com 2014 ;ISSN: 0964-6906 ;EISSN: 1460-2083 ;DOI: 10.1093/hmg/ddu153 ;PMID: 24698976

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8
Endothelial cell clonal expansion in the development of cerebral cavernous malformations
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Endothelial cell clonal expansion in the development of cerebral cavernous malformations

Nature communications, 2019-06, Vol.10 (1), p.2761-16, Article 2761 [Peer Reviewed Journal]

2019. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. ;The Author(s) 2019 ;ISSN: 2041-1723 ;EISSN: 2041-1723 ;DOI: 10.1038/s41467-019-10707-x ;PMID: 31235698

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9
Strategy for identifying repurposed drugs for the treatment of cerebral cavernous malformation
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Strategy for identifying repurposed drugs for the treatment of cerebral cavernous malformation

Circulation (New York, N.Y.), 2015-01, Vol.131 (3), p.289-299 [Peer Reviewed Journal]

2014 American Heart Association, Inc. ;ISSN: 0009-7322 ;EISSN: 1524-4539 ;DOI: 10.1161/CIRCULATIONAHA.114.010403 ;PMID: 25486933

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10
Loss of the transcription factor RBPJ induces disease-promoting properties in brain pericytes
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Loss of the transcription factor RBPJ induces disease-promoting properties in brain pericytes

Nature communications, 2019-06, Vol.10 (1), p.2817-19, Article 2817 [Peer Reviewed Journal]

2019. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. ;The Author(s) 2019 ;ISSN: 2041-1723 ;EISSN: 2041-1723 ;DOI: 10.1038/s41467-019-10643-w ;PMID: 31249304

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11
Cerebral Cavernous Malformation: What a Practicing Clinician Should Know
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Cerebral Cavernous Malformation: What a Practicing Clinician Should Know

Mayo Clinic proceedings, 2020-09, Vol.95 (9), p.2005-2020 [Peer Reviewed Journal]

2019 Mayo Foundation for Medical Education and Research ;Copyright © 2019 Mayo Foundation for Medical Education and Research. Published by Elsevier Inc. All rights reserved. ;COPYRIGHT 2020 Elsevier, Inc. ;Copyright Mayo Foundation for Medical Education and Research Sep 2020 ;ISSN: 0025-6196 ;EISSN: 1942-5546 ;DOI: 10.1016/j.mayocp.2019.11.005 ;PMID: 32605781

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12
Astrocytes propel neurovascular dysfunction during cerebral cavernous malformation lesion formation
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Astrocytes propel neurovascular dysfunction during cerebral cavernous malformation lesion formation

The Journal of clinical investigation, 2021-07, Vol.131 (13) [Peer Reviewed Journal]

COPYRIGHT 2021 American Society for Clinical Investigation ;Distributed under a Creative Commons Attribution 4.0 International License ;2021 American Society for Clinical Investigation 2021 American Society for Clinical Investigation ;ISSN: 1558-8238 ;ISSN: 0021-9738 ;EISSN: 1558-8238 ;DOI: 10.1172/JCI139570 ;PMID: 34043589

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13
Single-nucleus DNA sequencing reveals hidden somatic loss-of-heterozygosity in Cerebral Cavernous Malformations
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Single-nucleus DNA sequencing reveals hidden somatic loss-of-heterozygosity in Cerebral Cavernous Malformations

Nature communications, 2023-11, Vol.14 (1), p.7009-7009, Article 7009 [Peer Reviewed Journal]

2023. The Author(s). ;The Author(s) 2023. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. ;The Author(s) 2023 ;ISSN: 2041-1723 ;EISSN: 2041-1723 ;DOI: 10.1038/s41467-023-42908-w ;PMID: 37919320

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14
Magnetic Resonance Imaging of Mouse Cerebral Cavernomas Reveal Differential Lesion Progression and Variable Permeability to Gadolinium
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Magnetic Resonance Imaging of Mouse Cerebral Cavernomas Reveal Differential Lesion Progression and Variable Permeability to Gadolinium

Arteriosclerosis, thrombosis, and vascular biology, 2023-06, Vol.43 (6), p.958-970 [Peer Reviewed Journal]

ISSN: 1079-5642 ;EISSN: 1524-4636 ;DOI: 10.1161/ATVBAHA.122.318938 ;PMID: 37078284

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15
The natural history of intracranial cavernous malformations
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The natural history of intracranial cavernous malformations

Neurosurgical focus, 2011-06, Vol.30 (6), p.E24-E24 [Peer Reviewed Journal]

ISSN: 1092-0684 ;EISSN: 1092-0684 ;DOI: 10.3171/2011.3.focus1165 ;PMID: 21631226

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16
RhoA Kinase Inhibition With Fasudil Versus Simvastatin in Murine Models of Cerebral Cavernous Malformations
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RhoA Kinase Inhibition With Fasudil Versus Simvastatin in Murine Models of Cerebral Cavernous Malformations

Stroke (1970), 2017-01, Vol.48 (1), p.187-194 [Peer Reviewed Journal]

2017 American Heart Association, Inc. ;2016 American Heart Association, Inc. ;ISSN: 0039-2499 ;EISSN: 1524-4628 ;DOI: 10.1161/STROKEAHA.116.015013 ;PMID: 27879448

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17
Molecular Biomarkers and Drug Targets in Brain Arteriovenous and Cavernous Malformations: Where Are We?
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Article
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Molecular Biomarkers and Drug Targets in Brain Arteriovenous and Cavernous Malformations: Where Are We?

Stroke (1970), 2022-01, Vol.53 (1), p.279-289 [Peer Reviewed Journal]

ISSN: 0039-2499 ;EISSN: 1524-4628 ;DOI: 10.1161/strokeaha.121.035654 ;PMID: 34784742

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18
Connexin 43 gap junctions contribute to brain endothelial barrier hyperpermeability in familial cerebral cavernous malformations type III by modulating tight junction structure
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Connexin 43 gap junctions contribute to brain endothelial barrier hyperpermeability in familial cerebral cavernous malformations type III by modulating tight junction structure

The FASEB journal, 2018-05, Vol.32 (5), p.2615-2629 [Peer Reviewed Journal]

FASEB ;FASEB 2018 FASEB ;ISSN: 0892-6638 ;EISSN: 1530-6860 ;DOI: 10.1096/fj.201700699R ;PMID: 29295866

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19
Reliability of Functional and Diffusion MR Imaging Near Cerebral Cavernous Malformations
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Article
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Reliability of Functional and Diffusion MR Imaging Near Cerebral Cavernous Malformations

American journal of neuroradiology : AJNR, 2023-02, Vol.44 (2), p.150-156 [Peer Reviewed Journal]

2023 by American Journal of Neuroradiology. ;2023 by American Journal of Neuroradiology 2023 American Journal of Neuroradiology ;ISSN: 0195-6108 ;EISSN: 1936-959X ;DOI: 10.3174/ajnr.A7765 ;PMID: 36657950

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20
Clinical presentation, natural history and outcomes of intramedullary spinal cord cavernous malformations
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Article
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Clinical presentation, natural history and outcomes of intramedullary spinal cord cavernous malformations

Journal of neurology, neurosurgery and psychiatry, 2019-06, Vol.90 (6), p.695-703 [Peer Reviewed Journal]

Author(s) (or their employer(s)) 2019. No commercial re-use. See rights and permissions. Published by BMJ. ;2019 Author(s) (or their employer(s)) 2019. No commercial re-use. See rights and permissions. Published by BMJ. ;ISSN: 0022-3050 ;EISSN: 1468-330X ;DOI: 10.1136/jnnp-2018-319553 ;PMID: 30760644

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