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1
PHD3 Loss in Cancer Enables Metabolic Reliance on Fatty Acid Oxidation via Deactivation of ACC2
PHD3 Loss in Cancer Enables Metabolic Reliance on Fatty Acid Oxidation via Deactivation of ACC2
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PHD3 Loss in Cancer Enables Metabolic Reliance on Fatty Acid Oxidation via Deactivation of ACC2

Molecular cell, 2016-09, Vol.63 (6), p.1006-1020 [Peer Reviewed Journal]

2016 Elsevier Inc. ;Copyright © 2016 Elsevier Inc. All rights reserved. ;ISSN: 1097-2765 ;EISSN: 1097-4164 ;DOI: 10.1016/j.molcel.2016.08.014 ;PMID: 27635760

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2
PHDs/CPT1B/VDAC1 axis regulates long-chain fatty acid oxidation in cardiomyocytes
PHDs/CPT1B/VDAC1 axis regulates long-chain fatty acid oxidation in cardiomyocytes
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PHDs/CPT1B/VDAC1 axis regulates long-chain fatty acid oxidation in cardiomyocytes

Cell reports (Cambridge), 2021-10, Vol.37 (1), p.109767-109767, Article 109767 [Peer Reviewed Journal]

2021 The Authors ;Copyright © 2021 The Authors. Published by Elsevier Inc. All rights reserved. ;ISSN: 2211-1247 ;EISSN: 2211-1247 ;DOI: 10.1016/j.celrep.2021.109767 ;PMID: 34610308

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3
Oncometabolite 2-Hydroxyglutarate Is a Competitive Inhibitor of α-Ketoglutarate-Dependent Dioxygenases
Oncometabolite 2-Hydroxyglutarate Is a Competitive Inhibitor of α-Ketoglutarate-Dependent Dioxygenases
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Oncometabolite 2-Hydroxyglutarate Is a Competitive Inhibitor of α-Ketoglutarate-Dependent Dioxygenases

Cancer cell, 2011-01, Vol.19 (1), p.17-30 [Peer Reviewed Journal]

2011 Elsevier Inc. ;Copyright © 2011 Elsevier Inc. All rights reserved. ;2011 Elsevier Inc. 2011 ;ISSN: 1535-6108 ;EISSN: 1878-3686 ;DOI: 10.1016/j.ccr.2010.12.014 ;PMID: 21251613

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4
DFR1-Mediated Inhibition of Proline Degradation Pathway Regulates Drought and Freezing Tolerance in Arabidopsis
DFR1-Mediated Inhibition of Proline Degradation Pathway Regulates Drought and Freezing Tolerance in Arabidopsis
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DFR1-Mediated Inhibition of Proline Degradation Pathway Regulates Drought and Freezing Tolerance in Arabidopsis

Cell reports (Cambridge), 2018-06, Vol.23 (13), p.3960-3974 [Peer Reviewed Journal]

2018 The Author(s) ;Copyright © 2018 The Author(s). Published by Elsevier Inc. All rights reserved. ;ISSN: 2211-1247 ;EISSN: 2211-1247 ;DOI: 10.1016/j.celrep.2018.04.011 ;PMID: 29949777

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5
The Oxygen Sensor PHD2 Controls Dendritic Spines and Synapses via Modification of Filamin A
The Oxygen Sensor PHD2 Controls Dendritic Spines and Synapses via Modification of Filamin A
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The Oxygen Sensor PHD2 Controls Dendritic Spines and Synapses via Modification of Filamin A

Cell reports (Cambridge), 2016-03, Vol.14 (11), p.2653-2667 [Peer Reviewed Journal]

2016 The Authors ;Copyright © 2016 The Authors. Published by Elsevier Inc. All rights reserved. ;Attribution - NonCommercial - NoDerivatives ;2016 The Authors 2016 ;ISSN: 2211-1247 ;EISSN: 2211-1247 ;DOI: 10.1016/j.celrep.2016.02.047 ;PMID: 26972007

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6
Virus vaccines: proteins prefer prolines
Virus vaccines: proteins prefer prolines
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Virus vaccines: proteins prefer prolines

Cell host & microbe, 2021-03, Vol.29 (3), p.327-333 [Peer Reviewed Journal]

2021 Elsevier Inc. ;Copyright © 2021 Elsevier Inc. All rights reserved. ;2021 Elsevier Inc. 2021 Elsevier Inc. ;ISSN: 1931-3128 ;EISSN: 1934-6069 ;DOI: 10.1016/j.chom.2021.02.002 ;PMID: 33705704

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7
Obesity Shapes Metabolism in the Tumor Microenvironment to Suppress Anti-Tumor Immunity
Obesity Shapes Metabolism in the Tumor Microenvironment to Suppress Anti-Tumor Immunity
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Obesity Shapes Metabolism in the Tumor Microenvironment to Suppress Anti-Tumor Immunity

Cell, 2020-12, Vol.183 (7), p.1848-1866.e26 [Peer Reviewed Journal]

2020 ;Copyright © 2020. Published by Elsevier Inc. ;ISSN: 0092-8674 ;EISSN: 1097-4172 ;DOI: 10.1016/j.cell.2020.11.009 ;PMID: 33301708

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8
Structural Basis of TRPV4 N Terminus Interaction with Syndapin/PACSIN1-3 and PIP 2
Structural Basis of TRPV4 N Terminus Interaction with Syndapin/PACSIN1-3 and PIP 2
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Structural Basis of TRPV4 N Terminus Interaction with Syndapin/PACSIN1-3 and PIP 2

Structure (London), 2018-12, Vol.26 (12), p.1583 [Peer Reviewed Journal]

Copyright © 2018 Elsevier Ltd. All rights reserved. ;EISSN: 1878-4186 ;DOI: 10.1016/j.str.2018.08.002 ;PMID: 30244966

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9
Proline Isomer-Specific Antibodies Reveal the Early Pathogenic Tau Conformation in Alzheimer's Disease
Proline Isomer-Specific Antibodies Reveal the Early Pathogenic Tau Conformation in Alzheimer's Disease
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Proline Isomer-Specific Antibodies Reveal the Early Pathogenic Tau Conformation in Alzheimer's Disease

Cell, 2012-03, Vol.149 (1), p.232-244 [Peer Reviewed Journal]

2012 Elsevier Inc. ;Copyright © 2012 Elsevier Inc. All rights reserved. ;2012 Elsevier Inc. All rights reserved. 2012 ;ISSN: 0092-8674 ;EISSN: 1097-4172 ;DOI: 10.1016/j.cell.2012.02.016 ;PMID: 22464332

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10
A genome-scale gain-of-function CRISPR screen in CD8 T cells identifies proline metabolism as a means to enhance CAR-T therapy
A genome-scale gain-of-function CRISPR screen in CD8 T cells identifies proline metabolism as a means to enhance CAR-T therapy
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A genome-scale gain-of-function CRISPR screen in CD8 T cells identifies proline metabolism as a means to enhance CAR-T therapy

Cell metabolism, 2022-04, Vol.34 (4), p.595-614.e14 [Peer Reviewed Journal]

2022 Elsevier Inc. ;Copyright © 2022 Elsevier Inc. All rights reserved. ;ISSN: 1550-4131 ;EISSN: 1932-7420 ;DOI: 10.1016/j.cmet.2022.02.009 ;PMID: 35276062

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11
Stress-Triggered Phase Separation Is an Adaptive, Evolutionarily Tuned Response
Stress-Triggered Phase Separation Is an Adaptive, Evolutionarily Tuned Response
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Stress-Triggered Phase Separation Is an Adaptive, Evolutionarily Tuned Response

Cell, 2017-03, Vol.168 (6), p.1028-1040.e19 [Peer Reviewed Journal]

2017 Elsevier Inc. ;Copyright © 2017 Elsevier Inc. All rights reserved. ;ISSN: 0092-8674 ;EISSN: 1097-4172 ;DOI: 10.1016/j.cell.2017.02.027 ;PMID: 28283059

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12
Succinate links TCA cycle dysfunction to oncogenesis by inhibiting HIF-α prolyl hydroxylase
Succinate links TCA cycle dysfunction to oncogenesis by inhibiting HIF-α prolyl hydroxylase
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Succinate links TCA cycle dysfunction to oncogenesis by inhibiting HIF-α prolyl hydroxylase

Cancer cell, 2005, Vol.7 (1), p.77-85 [Peer Reviewed Journal]

2005 Elsevier Inc. ;ISSN: 1535-6108 ;EISSN: 1878-3686 ;DOI: 10.1016/j.ccr.2004.11.022 ;PMID: 15652751

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13
Functional Consequences of PRODH Missense Mutations
Functional Consequences of PRODH Missense Mutations
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Functional Consequences of PRODH Missense Mutations

American journal of human genetics, 2005-03, Vol.76 (3), p.409-420 [Peer Reviewed Journal]

2005 The American Society of Human Genetics ;2005 INIST-CNRS ;Copyright University of Chicago, acting through its Press Mar 2005 ;2005 by The American Society of Human Genetics. All rights reserved. 2005 ;ISSN: 0002-9297 ;EISSN: 1537-6605 ;DOI: 10.1086/428142 ;PMID: 15662599 ;CODEN: AJHGAG

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14
Adipocyte Hypoxia-Inducible Factor 2α Suppresses Atherosclerosis by Promoting Adipose Ceramide Catabolism
Adipocyte Hypoxia-Inducible Factor 2α Suppresses Atherosclerosis by Promoting Adipose Ceramide Catabolism
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Adipocyte Hypoxia-Inducible Factor 2α Suppresses Atherosclerosis by Promoting Adipose Ceramide Catabolism

Cell metabolism, 2019-11, Vol.30 (5), p.937-951.e5 [Peer Reviewed Journal]

Copyright © 2019 Elsevier Inc. All rights reserved. ;ISSN: 1550-4131 ;EISSN: 1932-7420 ;DOI: 10.1016/j.cmet.2019.09.016 ;PMID: 31668872

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15
Gene-Targeting of Phd2 Improves Tumor Response to Chemotherapy and Prevents Side-Toxicity
Gene-Targeting of Phd2 Improves Tumor Response to Chemotherapy and Prevents Side-Toxicity
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Gene-Targeting of Phd2 Improves Tumor Response to Chemotherapy and Prevents Side-Toxicity

Cancer cell, 2012-08, Vol.22 (2), p.263-277 [Peer Reviewed Journal]

2012 Elsevier Inc. ;Copyright © 2012 Elsevier Inc. All rights reserved. ;ISSN: 1535-6108 ;EISSN: 1878-3686 ;DOI: 10.1016/j.ccr.2012.06.028 ;PMID: 22897855

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16
Oxygen Sensing by Metazoans: The Central Role of the HIF Hydroxylase Pathway
Oxygen Sensing by Metazoans: The Central Role of the HIF Hydroxylase Pathway
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Oxygen Sensing by Metazoans: The Central Role of the HIF Hydroxylase Pathway

Molecular cell, 2008-05, Vol.30 (4), p.393-402 [Peer Reviewed Journal]

2008 Elsevier Inc. ;ISSN: 1097-2765 ;EISSN: 1097-4164 ;DOI: 10.1016/j.molcel.2008.04.009 ;PMID: 18498744

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17
Proline Hydroxylation Primes Protein Kinases for Autophosphorylation and Activation
Proline Hydroxylation Primes Protein Kinases for Autophosphorylation and Activation
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Proline Hydroxylation Primes Protein Kinases for Autophosphorylation and Activation

Molecular cell, 2020-08, Vol.79 (3), p.376-389.e8 [Peer Reviewed Journal]

2020 Elsevier Inc. ;Copyright © 2020 Elsevier Inc. All rights reserved. ;ISSN: 1097-2765 ;EISSN: 1097-4164 ;DOI: 10.1016/j.molcel.2020.06.021 ;PMID: 32640193

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18
Proline synthesis through PYCR1 is required to support cancer cell proliferation and survival in oxygen-limiting conditions
Proline synthesis through PYCR1 is required to support cancer cell proliferation and survival in oxygen-limiting conditions
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Proline synthesis through PYCR1 is required to support cancer cell proliferation and survival in oxygen-limiting conditions

Cell reports (Cambridge), 2022-02, Vol.38 (5), p.110320-110320, Article 110320 [Peer Reviewed Journal]

2022 The Authors ;Copyright © 2022 The Authors. Published by Elsevier Inc. All rights reserved. ;2022 The Authors 2022 ;ISSN: 2211-1247 ;EISSN: 2211-1247 ;DOI: 10.1016/j.celrep.2022.110320 ;PMID: 35108535

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19
Structural Basis for Binding of Hypoxia-Inducible Factor to the Oxygen-Sensing Prolyl Hydroxylases
Structural Basis for Binding of Hypoxia-Inducible Factor to the Oxygen-Sensing Prolyl Hydroxylases
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Structural Basis for Binding of Hypoxia-Inducible Factor to the Oxygen-Sensing Prolyl Hydroxylases

Structure (London), 2009-07, Vol.17 (7), p.981-989 [Peer Reviewed Journal]

2009 Elsevier Ltd ;ISSN: 0969-2126 ;EISSN: 1878-4186 ;DOI: 10.1016/j.str.2009.06.002 ;PMID: 19604478

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20
Proline Starvation Induces Unresolved ER Stress and Hinders mTORC1-Dependent Tumorigenesis
Proline Starvation Induces Unresolved ER Stress and Hinders mTORC1-Dependent Tumorigenesis
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Proline Starvation Induces Unresolved ER Stress and Hinders mTORC1-Dependent Tumorigenesis

Cell metabolism, 2016-11, Vol.24 (5), p.753-761 [Peer Reviewed Journal]

2016 Elsevier Inc. ;Copyright © 2016 Elsevier Inc. All rights reserved. ;ISSN: 1550-4131 ;EISSN: 1932-7420 ;DOI: 10.1016/j.cmet.2016.08.008 ;PMID: 27618686

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