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Journal Title: Plos Computational Biology

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1	Material Type: Article	CRIMSON: An open-source software framework for cardiovascular integrated modelling and simulation PLoS computational biology, 2021-05, Vol.17 (5), p.e1008881-e1008881 [Peer Reviewed Journal] COPYRIGHT 2021 Public Library of Science ;2021 Arthurs et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. ;2021 Arthurs et al 2021 Arthurs et al ;ISSN: 1553-7358 ;ISSN: 1553-734X ;EISSN: 1553-7358 ;DOI: 10.1371/journal.pcbi.1008881 ;PMID: 33970900 Full text available View Online Details Recommendations Reviews Times Cited External Links Citations Cited by
2	Material Type: Article	Computational prediction of drug response in short QT syndrome type 1 based on measurements of compound effect in stem cell-derived cardiomyocytes PLoS computational biology, 2021-02, Vol.17 (2), p.e1008089-e1008089 [Peer Reviewed Journal] 2021 Jæger et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. ;2021 Jæger et al 2021 Jæger et al ;ISSN: 1553-7358 ;ISSN: 1553-734X ;EISSN: 1553-7358 ;DOI: 10.1371/journal.pcbi.1008089 ;PMID: 33591962 Full text available View Online Details Recommendations Reviews Times Cited External Links Citations Cited by
3	Material Type: Article	Predictive model identifies key network regulators of cardiomyocyte mechano-signaling PLoS computational biology, 2017-11, Vol.13 (11), p.e1005854-e1005854 [Peer Reviewed Journal] COPYRIGHT 2017 Public Library of Science ;COPYRIGHT 2017 Public Library of Science ;2017 Public Library of Science. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited: Tan PM, Buchholz KS, Omens JH, McCulloch AD, Saucerman JJ (2017) Predictive model identifies key network regulators of cardiomyocyte mechano-signaling. PLoS Comput Biol 13(11): e1005854. https://doi.org/10.1371/journal.pcbi.1005854 ;2017 Tan et al 2017 Tan et al ;2017 Public Library of Science. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited: Tan PM, Buchholz KS, Omens JH, McCulloch AD, Saucerman JJ (2017) Predictive model identifies key network regulators of cardiomyocyte mechano-signaling. PLoS Comput Biol 13(11): e1005854. https://doi.org/10.1371/journal.pcbi.1005854 ;ISSN: 1553-7358 ;ISSN: 1553-734X ;EISSN: 1553-7358 ;DOI: 10.1371/journal.pcbi.1005854 ;PMID: 29131824 Full text available View Online Details Recommendations Reviews Times Cited External Links Citations Cited by
4	Material Type: Article	A method to quantify mechanobiologic forces during zebrafish cardiac development using 4-D light sheet imaging and computational modeling PLoS computational biology, 2017-10, Vol.13 (10), p.e1005828-e1005828 [Peer Reviewed Journal] COPYRIGHT 2017 Public Library of Science ;COPYRIGHT 2017 Public Library of Science ;2017 Public Library of Science. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited: Vedula V, Lee J, Xu H, Kuo C-CJ, Hsiai TK, Marsden AL (2017) A method to quantify mechanobiologic forces during zebrafish cardiac development using 4-D light sheet imaging and computational modeling. PLoS Comput Biol13(10): e1005828. https://doi.org/10.1371/journal.pcbi.1005828 ;2017 Vedula et al 2017 Vedula et al ;2017 Public Library of Science. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited: Vedula V, Lee J, Xu H, Kuo C-CJ, Hsiai TK, Marsden AL (2017) A method to quantify mechanobiologic forces during zebrafish cardiac development using 4-D light sheet imaging and computational modeling. PLoS Comput Biol13(10): e1005828. https://doi.org/10.1371/journal.pcbi.1005828 ;ISSN: 1553-7358 ;ISSN: 1553-734X ;EISSN: 1553-7358 ;DOI: 10.1371/journal.pcbi.1005828 ;PMID: 29084212 Full text available View Online Details Recommendations Reviews Times Cited External Links Citations Cited by
5	Material Type: Article	Leveraging epigenomes and three-dimensional genome organization for interpreting regulatory variation PLoS computational biology, 2023-07, Vol.19 (7), p.e1011286-e1011286 [Peer Reviewed Journal] Copyright: © 2023 Baur et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. ;COPYRIGHT 2023 Public Library of Science ;2023 Baur et al 2023 Baur et al ;2023 Baur et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. ;ISSN: 1553-7358 ;ISSN: 1553-734X ;EISSN: 1553-7358 ;DOI: 10.1371/journal.pcbi.1011286 ;PMID: 37428809 Full text available View Online Details Recommendations Reviews Times Cited External Links Citations Cited by
6	Material Type: Article	Mathematical modeling to understand the role of bivalent thrombin-fibrin binding during polymerization PLoS computational biology, 2022-09, Vol.18 (9), p.e1010414-e1010414 [Peer Reviewed Journal] COPYRIGHT 2022 Public Library of Science ;2022 Kelley, Leiderman 2022 Kelley, Leiderman ;2022 Kelley, Leiderman. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. ;ISSN: 1553-7358 ;ISSN: 1553-734X ;EISSN: 1553-7358 ;DOI: 10.1371/journal.pcbi.1010414 ;PMID: 36107837 Full text available View Online Details Recommendations Reviews Times Cited External Links Citations Cited by
7	Material Type: Article	Increased A-to-I RNA editing in atherosclerosis and cardiomyopathies PLoS computational biology, 2023-04, Vol.19 (4), p.e1010923-e1010923 [Peer Reviewed Journal] Copyright: © 2023 Mann et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. ;COPYRIGHT 2023 Public Library of Science ;2023 Mann et al 2023 Mann et al ;2023 Mann et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. ;ISSN: 1553-7358 ;ISSN: 1553-734X ;EISSN: 1553-7358 ;DOI: 10.1371/journal.pcbi.1010923 ;PMID: 37036839 Full text available View Online Details Recommendations Reviews Times Cited External Links Citations Cited by
8	Material Type: Article	A computational model of spatio-temporal cardiac intracellular calcium handling with realistic structure and spatial flux distribution from sarcoplasmic reticulum and t-tubule reconstructions PLoS computational biology, 2017-08, Vol.13 (8), p.e1005714-e1005714 [Peer Reviewed Journal] COPYRIGHT 2017 Public Library of Science ;COPYRIGHT 2017 Public Library of Science ;2017 Public Library of Science. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited: Colman MA, Pinali C, Trafford AW, Zhang H, Kitmitto A (2017) A computational model of spatio-temporal cardiac intracellular calcium handling with realistic structure and spatial flux distribution from sarcoplasmic reticulum and t-tubule reconstructions. PLoS Comput Biol 13(8): e1005714. https://doi.org/10.1371/journal.pcbi.1005714 ;2017 Colman et al 2017 Colman et al ;2017 Public Library of Science. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited: Colman MA, Pinali C, Trafford AW, Zhang H, Kitmitto A (2017) A computational model of spatio-temporal cardiac intracellular calcium handling with realistic structure and spatial flux distribution from sarcoplasmic reticulum and t-tubule reconstructions. PLoS Comput Biol 13(8): e1005714. https://doi.org/10.1371/journal.pcbi.1005714 ;ISSN: 1553-7358 ;ISSN: 1553-734X ;EISSN: 1553-7358 ;DOI: 10.1371/journal.pcbi.1005714 ;PMID: 28859079 Full text available View Online Details Recommendations Reviews Times Cited External Links Citations Cited by
9	Material Type: Article	Measurable health effects associated with the daylight saving time shift PLoS computational biology, 2020-06, Vol.16 (6), p.e1007927-e1007927 [Peer Reviewed Journal] COPYRIGHT 2020 Public Library of Science ;COPYRIGHT 2020 Public Library of Science ;2020 Zhang et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. ;2020 Zhang et al 2020 Zhang et al ;ISSN: 1553-7358 ;ISSN: 1553-734X ;EISSN: 1553-7358 ;DOI: 10.1371/journal.pcbi.1007927 ;PMID: 32511231 Full text available View Online Details Recommendations Reviews Times Cited External Links Citations Cited by
10	Material Type: Article	A computational model of pig ventricular cardiomyocyte electrophysiology and calcium handling: Translation from pig to human electrophysiology PLoS computational biology, 2021-06, Vol.17 (6), p.e1009137-e1009137 [Peer Reviewed Journal] COPYRIGHT 2021 Public Library of Science ;2021 Gaur et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. ;2021 Gaur et al 2021 Gaur et al ;ISSN: 1553-7358 ;ISSN: 1553-734X ;EISSN: 1553-7358 ;DOI: 10.1371/journal.pcbi.1009137 ;PMID: 34191797 Full text available View Online Details Recommendations Reviews Times Cited External Links Citations Cited by
11	$Self-organization of conducting pathways explains electrical wave propagation in cardiac tissues with high fraction of non-conducting cells$ $Self-organization of conducting pathways explains electrical wave propagation in cardiac tissues with high fraction of non-conducting cells$ Material Type: Article	Self-organization of conducting pathways explains electrical wave propagation in cardiac tissues with high fraction of non-conducting cells PLoS computational biology, 2019-03, Vol.15 (3), p.e1006597-e1006597 [Peer Reviewed Journal] COPYRIGHT 2019 Public Library of Science ;COPYRIGHT 2019 Public Library of Science ;2019 Kudryashova et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. ;2019 Kudryashova et al 2019 Kudryashova et al ;ISSN: 1553-7358 ;ISSN: 1553-734X ;EISSN: 1553-7358 ;DOI: 10.1371/journal.pcbi.1006597 ;PMID: 30883540 Full text available View Online Details Recommendations Reviews Times Cited External Links Citations Cited by
12	Material Type: Article	Use of Angiotensin-Converting Enzyme Inhibitors and Angiotensin II Receptor Blockers During the COVID-19 Pandemic: A Modeling Analysis PLoS computational biology, 2020-10, Vol.16 (10), p.e1008235-e1008235 [Peer Reviewed Journal] COPYRIGHT 2020 Public Library of Science ;COPYRIGHT 2020 Public Library of Science ;2020 Sadria, Layton. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. ;2020 Sadria, Layton 2020 Sadria, Layton ;ISSN: 1553-7358 ;ISSN: 1553-734X ;EISSN: 1553-7358 ;DOI: 10.1371/journal.pcbi.1008235 ;PMID: 33031368 Full text available View Online Details Recommendations Reviews Times Cited External Links Citations Cited by
13	Material Type: Article	Microheterogeneity-induced conduction slowing and wavefront collisions govern macroscopic conduction behavior: A computational and experimental study PLoS computational biology, 2018-07, Vol.14 (7), p.e1006276-e1006276 [Peer Reviewed Journal] COPYRIGHT 2018 Public Library of Science ;COPYRIGHT 2018 Public Library of Science ;2018 Gokhale et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. ;2018 Gokhale et al 2018 Gokhale et al ;ISSN: 1553-7358 ;ISSN: 1553-734X ;EISSN: 1553-7358 ;DOI: 10.1371/journal.pcbi.1006276 ;PMID: 30011279 Full text available View Online Details Recommendations Reviews Times Cited External Links Citations Cited by
14	Material Type: Article	A model for cooperative gating of L-type Ca2+ channels and its effects on cardiac alternans dynamics PLoS computational biology, 2018-01, Vol.14 (1), p.e1005906-e1005906 [Peer Reviewed Journal] 2018 Public Library of Science. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited: channels and its effects on cardiac alternans dynamics. PLoS Comput Biol 14(1): e1005906. https://doi.org/10.1371/journal.pcbi.1005906 ;2018 Sato et al 2018 Sato et al ;2018 Public Library of Science. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited: channels and its effects on cardiac alternans dynamics. PLoS Comput Biol 14(1): e1005906. https://doi.org/10.1371/journal.pcbi.1005906 ;ISSN: 1553-7358 ;ISSN: 1553-734X ;EISSN: 1553-7358 ;DOI: 10.1371/journal.pcbi.1005906 ;PMID: 29338006 Full text available View Online Details Recommendations Reviews Times Cited External Links Citations Cited by
15	Material Type: Article	Allosteric modulation of cardiac myosin dynamics by omecamtiv mecarbil PLoS computational biology, 2017-11, Vol.13 (11), p.e1005826-e1005826 [Peer Reviewed Journal] COPYRIGHT 2017 Public Library of Science ;COPYRIGHT 2017 Public Library of Science ;2017 Public Library of Science. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited: Hashem S, Tiberti M, Fornili A (2017) Allosteric modulation of cardiac myosin dynamics by omecamtiv mecarbil. PLoS Comput Biol 13(11): e1005826. https://doi.org/10.1371/journal.pcbi.1005826 ;2017 Hashem et al 2017 Hashem et al ;2017 Public Library of Science. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited: Hashem S, Tiberti M, Fornili A (2017) Allosteric modulation of cardiac myosin dynamics by omecamtiv mecarbil. PLoS Comput Biol 13(11): e1005826. https://doi.org/10.1371/journal.pcbi.1005826 ;ISSN: 1553-7358 ;ISSN: 1553-734X ;EISSN: 1553-7358 ;DOI: 10.1371/journal.pcbi.1005826 ;PMID: 29108014 Full text available View Online Details Recommendations Reviews Times Cited External Links Citations Cited by
16	Material Type: Article	Estimating the probabilities of rare arrhythmic events in multiscale computational models of cardiac cells and tissue PLoS computational biology, 2017-11, Vol.13 (11), p.e1005783-e1005783 [Peer Reviewed Journal] COPYRIGHT 2017 Public Library of Science ;COPYRIGHT 2017 Public Library of Science ;2017 Public Library of Science. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited: Walker MA, Gurev V, Rice JJ, Greenstein JL, Winslow RL (2017) Estimating the probabilities of rare arrhythmic events in multiscale computational models of cardiac cells and tissue. PLoS Comput Biol 13(11): e1005783. https://doi.org/10.1371/journal.pcbi.1005783 ;2017 Walker et al 2017 Walker et al ;2017 Public Library of Science. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited: Walker MA, Gurev V, Rice JJ, Greenstein JL, Winslow RL (2017) Estimating the probabilities of rare arrhythmic events in multiscale computational models of cardiac cells and tissue. PLoS Comput Biol 13(11): e1005783. https://doi.org/10.1371/journal.pcbi.1005783 ;ISSN: 1553-7358 ;ISSN: 1553-734X ;EISSN: 1553-7358 ;DOI: 10.1371/journal.pcbi.1005783 ;PMID: 29145393 Full text available View Online Details Recommendations Reviews Times Cited External Links Citations Cited by
17	Material Type: Article	Stabilization of diastolic calcium signal via calcium pump regulation of complex local calcium releases and transient decay in a computational model of cardiac pacemaker cell with individual release channels PLoS computational biology, 2017-08, Vol.13 (8), p.e1005675-e1005675 [Peer Reviewed Journal] COPYRIGHT 2017 Public Library of Science ;COPYRIGHT 2017 Public Library of Science ;2017 Public Library of Science. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited: Maltsev AV, Maltsev VA, Stern MD (2017) Stabilization of diastolic calcium signal via calcium pump regulation of complex local calcium releases and transient decay in a computational model of cardiac pacemaker cell with individual release channels. PLoS Comput Biol 13(8): e1005675. https://doi.org/10.1371/journal.pcbi.1005675 ;2017 Public Library of Science. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited: Maltsev AV, Maltsev VA, Stern MD (2017) Stabilization of diastolic calcium signal via calcium pump regulation of complex local calcium releases and transient decay in a computational model of cardiac pacemaker cell with individual release channels. PLoS Comput Biol 13(8): e1005675. https://doi.org/10.1371/journal.pcbi.1005675 ;ISSN: 1553-7358 ;ISSN: 1553-734X ;EISSN: 1553-7358 ;DOI: 10.1371/journal.pcbi.1005675 ;PMID: 28792496 Full text available View Online Details Recommendations Reviews Times Cited External Links Citations Cited by
18	Material Type: Article	In silico study of multicellular automaticity of heterogeneous cardiac cell monolayers: Effects of automaticity strength and structural linear anisotropy PLoS computational biology, 2018-03, Vol.14 (3), p.e1005978-e1005978 [Peer Reviewed Journal] COPYRIGHT 2018 Public Library of Science ;COPYRIGHT 2018 Public Library of Science ;2018 Public Library of Science. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited: Duverger JE, Jacquemet V, Vinet A, Comtois P (2018) In silico study of multicellular automaticity of heterogeneous cardiac cell monolayers: Effects of automaticity strength and structural linear anisotropy. PLoS Comput Biol 14(3): e1005978. https://doi.org/10.1371/journal.pcbi.1005978 ;2018 Duverger et al 2018 Duverger et al ;2018 Public Library of Science. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited: Duverger JE, Jacquemet V, Vinet A, Comtois P (2018) In silico study of multicellular automaticity of heterogeneous cardiac cell monolayers: Effects of automaticity strength and structural linear anisotropy. PLoS Comput Biol 14(3): e1005978. https://doi.org/10.1371/journal.pcbi.1005978 ;ISSN: 1553-7358 ;ISSN: 1553-734X ;EISSN: 1553-7358 ;DOI: 10.1371/journal.pcbi.1005978 ;PMID: 29529023 Full text available View Online Details Recommendations Reviews Times Cited External Links Citations Cited by
19	Material Type: Article	Mechanisms of ventricular arrhythmias elicited by coexistence of multiple electrophysiological remodeling in ischemia: A simulation study PLoS computational biology, 2022-04, Vol.18 (4), p.e1009388-e1009388 [Peer Reviewed Journal] COPYRIGHT 2022 Public Library of Science ;2022 Liang et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. ;2022 Liang et al 2022 Liang et al ;ISSN: 1553-7358 ;ISSN: 1553-734X ;EISSN: 1553-7358 ;DOI: 10.1371/journal.pcbi.1009388 ;PMID: 35476614 Full text available View Online Details Recommendations Reviews Times Cited External Links Citations Cited by
20	Material Type: Article	Lipid exchange mechanism of the cholesteryl ester transfer protein clarified by atomistic and coarse-grained simulations PLoS computational biology, 2012-01, Vol.8 (1), p.e1002299-e1002299 [Peer Reviewed Journal] COPYRIGHT 2012 Public Library of Science ;COPYRIGHT 2012 Public Library of Science ;2012 Koivuniemi et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited: Koivuniemi A, Vuorela T, Kovanen PT, Vattulainen I, Hyvönen MT (2012) Lipid Exchange Mechanism of the Cholesteryl Ester Transfer Protein Clarified by Atomistic and Coarse-grained Simulations. PLoS Comput Biol 8(1): e1002299. doi:10.1371/journal.pcbi.1002299 ;Koivuniemi et al. 2012 ;ISSN: 1553-7358 ;ISSN: 1553-734X ;EISSN: 1553-7358 ;DOI: 10.1371/journal.pcbi.1002299 ;PMID: 22253581 Full text available View Online Details Recommendations Reviews Times Cited External Links Citations Cited by