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Results 1 - 20 of 53  for All Library Resources

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1
Expanding the Library of 1,2,4-Oxadiazole Derivatives: Discovery of New Farnesoid X Receptor (FXR) Antagonists/Pregnane X Receptor (PXR) Agonists
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Expanding the Library of 1,2,4-Oxadiazole Derivatives: Discovery of New Farnesoid X Receptor (FXR) Antagonists/Pregnane X Receptor (PXR) Agonists

Molecules (Basel, Switzerland), 2023-03, Vol.28 (6), p.2840 [Peer Reviewed Journal]

2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. ;2023 by the authors. 2023 ;ISSN: 1420-3049 ;EISSN: 1420-3049 ;DOI: 10.3390/molecules28062840 ;PMID: 36985811

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2
State-of-the-Art Methodologies for the Discovery and Characterization of DNA G-Quadruplex Binders
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Article
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State-of-the-Art Methodologies for the Discovery and Characterization of DNA G-Quadruplex Binders

Current pharmaceutical design, 2012-05, Vol.18 (14), p.1880-1899 [Peer Reviewed Journal]

ISSN: 1381-6128 ;ISSN: 1873-4286 ;EISSN: 1873-4286 ;DOI: 10.2174/138161212799958332 ;PMID: 22376104

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3
Targeting SARS-CoV-2 Proteases and Polymerase for COVID-19 Treatment: State of the Art and Future Opportunities
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Article
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Targeting SARS-CoV-2 Proteases and Polymerase for COVID-19 Treatment: State of the Art and Future Opportunities

Journal of medicinal chemistry, 2022-02, Vol.65 (4), p.2716 [Peer Reviewed Journal]

EISSN: 1520-4804 ;DOI: 10.1021/acs.jmedchem.0c01140 ;PMID: 33186044

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4
Marine and semi-synthetic hydroxysteroids as new scaffolds for pregnane X receptor modulation
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Article
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Marine and semi-synthetic hydroxysteroids as new scaffolds for pregnane X receptor modulation

Marine drugs, 2014-05, Vol.12 (6), p.3091-3115 [Peer Reviewed Journal]

Copyright MDPI AG 2014 ;2014 by the authors; licensee MDPI, Basel, Switzerland. 2014 ;ISSN: 1660-3397 ;EISSN: 1660-3397 ;DOI: 10.3390/md12063091 ;PMID: 24871460

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5
Broad-spectrum coronavirus 3C-like protease peptidomimetic inhibitors effectively block SARS-CoV-2 replication in cells: Design, synthesis, biological evaluation, and X-ray structure determination
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Article
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Broad-spectrum coronavirus 3C-like protease peptidomimetic inhibitors effectively block SARS-CoV-2 replication in cells: Design, synthesis, biological evaluation, and X-ray structure determination

European journal of medicinal chemistry, 2023-05, Vol.253, p.115311 [Peer Reviewed Journal]

Copyright © 2023 Elsevier Masson SAS. All rights reserved. ;EISSN: 1768-3254 ;DOI: 10.1016/j.ejmech.2023.115311 ;PMID: 37043904

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6
Stable Peptides Instead of Stapled Peptides: Highly Potent αvβ6-Selective Integrin Ligands
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Article
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Stable Peptides Instead of Stapled Peptides: Highly Potent αvβ6-Selective Integrin Ligands

Angewandte Chemie International Edition, 2016-01, Vol.55 (4), p.1535 [Peer Reviewed Journal]

2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. ;EISSN: 1521-3773 ;DOI: 10.1002/anie.201508709 ;PMID: 26663660

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7
Identification of highly conserved residues involved in inhibition of HIV-1 RNase H function by Diketo acid derivatives
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Article
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Identification of highly conserved residues involved in inhibition of HIV-1 RNase H function by Diketo acid derivatives

Antimicrobial agents and chemotherapy, 2014-10, Vol.58 (10), p.6101-6110 [Peer Reviewed Journal]

Copyright © 2014, American Society for Microbiology. All Rights Reserved. ;Copyright © 2014, American Society for Microbiology. All Rights Reserved. 2014 American Society for Microbiology ;ISSN: 0066-4804 ;EISSN: 1098-6596 ;DOI: 10.1128/aac.03605-14 ;PMID: 25092689

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8
Rational improvement of the affinity and selectivity of integrin binding of grafted lasso peptides
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Article
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Rational improvement of the affinity and selectivity of integrin binding of grafted lasso peptides

Journal of medicinal chemistry, 2014-07, Vol.57 (13), p.5829 [Peer Reviewed Journal]

EISSN: 1520-4804 ;DOI: 10.1021/jm5004478 ;PMID: 24949551

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9
The Inhibition of DNA Viruses by the Amphibian Antimicrobial Peptide Temporin G: A Virological Study Addressing HSV-1 and JPCyV
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Article
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The Inhibition of DNA Viruses by the Amphibian Antimicrobial Peptide Temporin G: A Virological Study Addressing HSV-1 and JPCyV

International journal of molecular sciences, 2022-06, Vol.23 (13), p.7194 [Peer Reviewed Journal]

2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. ;2022 by the authors. 2022 ;ISSN: 1422-0067 ;ISSN: 1661-6596 ;EISSN: 1422-0067 ;DOI: 10.3390/ijms23137194 ;PMID: 35806198

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10
Overcoming the Lack of Oral Availability of Cyclic Hexapeptides: Design of a Selective and Orally Available Ligand for the Integrin αvβ3
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Article
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Overcoming the Lack of Oral Availability of Cyclic Hexapeptides: Design of a Selective and Orally Available Ligand for the Integrin αvβ3

Angewandte Chemie International Edition, 2017-12, Vol.56 (51), p.16405 [Peer Reviewed Journal]

2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim. ;EISSN: 1521-3773 ;DOI: 10.1002/anie.201709709 ;PMID: 29072809

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11
Bioinformatics and Biosimulations as Toolbox for Peptides and Peptidomimetics Design: Where Are We?
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Article
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Bioinformatics and Biosimulations as Toolbox for Peptides and Peptidomimetics Design: Where Are We?

Frontiers in molecular biosciences, 2020-05, Vol.7, p.66 [Peer Reviewed Journal]

Copyright © 2020 D’Annessa, Di Leva, La Teana, Novellino, Limongelli and Di Marino. ;Copyright © 2020 D’Annessa, Di Leva, La Teana, Novellino, Limongelli and Di Marino. 2020 D’Annessa, Di Leva, La Teana, Novellino, Limongelli and Di Marino ;ISSN: 2296-889X ;EISSN: 2296-889X ;DOI: 10.3389/fmolb.2020.00066 ;PMID: 32432124

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12
Discovery of ((1,2,4-oxadiazol-5-yl)pyrrolidin-3-yl)ureidyl derivatives as selective non-steroidal agonists of the G-protein coupled bile acid receptor-1
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Article
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Discovery of ((1,2,4-oxadiazol-5-yl)pyrrolidin-3-yl)ureidyl derivatives as selective non-steroidal agonists of the G-protein coupled bile acid receptor-1

Scientific reports, 2019-02, Vol.9 (1), p.2504-2504, Article 2504 [Peer Reviewed Journal]

This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. ;The Author(s) 2019 ;ISSN: 2045-2322 ;EISSN: 2045-2322 ;DOI: 10.1038/s41598-019-38840-z ;PMID: 30792450

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13
Exploring the chemical space of G-quadruplex binders: discovery of a novel chemotype targeting the human telomeric sequence
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Article
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Exploring the chemical space of G-quadruplex binders: discovery of a novel chemotype targeting the human telomeric sequence

Journal of medicinal chemistry, 2013-12, Vol.56 (23), p.9646 [Peer Reviewed Journal]

EISSN: 1520-4804 ;DOI: 10.1021/jm401185b ;PMID: 24256368

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14
Investigation around the Oxadiazole Core in the Discovery of a New Chemotype of Potent and Selective FXR Antagonists
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Article
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Investigation around the Oxadiazole Core in the Discovery of a New Chemotype of Potent and Selective FXR Antagonists

ACS medicinal chemistry letters, 2019-04, Vol.10 (4), p.504-510 [Peer Reviewed Journal]

Copyright © 2019 American Chemical Society 2019 American Chemical Society ;ISSN: 1948-5875 ;EISSN: 1948-5875 ;DOI: 10.1021/acsmedchemlett.8b00534 ;PMID: 30996787

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15
Binding mechanism of the farnesoid X receptor marine antagonist suvanine reveals a strategy to forestall drug modulation on nuclear receptors. Design, synthesis, and biological evaluation of novel ligands
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Article
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Binding mechanism of the farnesoid X receptor marine antagonist suvanine reveals a strategy to forestall drug modulation on nuclear receptors. Design, synthesis, and biological evaluation of novel ligands

Journal of medicinal chemistry, 2013-06, Vol.56 (11), p.4701 [Peer Reviewed Journal]

EISSN: 1520-4804 ;DOI: 10.1021/jm400419e ;PMID: 23656455

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16
Structure-based drug design targeting the cell membrane receptor GPBAR1: exploiting the bile acid scaffold towards selective agonism
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Article
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Structure-based drug design targeting the cell membrane receptor GPBAR1: exploiting the bile acid scaffold towards selective agonism

Scientific reports, 2015-11, Vol.5 (1), p.16605-16605, Article 16605 [Peer Reviewed Journal]

Copyright Nature Publishing Group Nov 2015 ;Copyright © 2015, Macmillan Publishers Limited 2015 Macmillan Publishers Limited ;ISSN: 2045-2322 ;EISSN: 2045-2322 ;DOI: 10.1038/srep16605 ;PMID: 26567894

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17
The ring residue proline 8 is crucial for the thermal stability of the lasso peptide caulosegnin II
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Article
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The ring residue proline 8 is crucial for the thermal stability of the lasso peptide caulosegnin II

Molecular bioSystems, 2016-01, Vol.12 (4), p.1106 [Peer Reviewed Journal]

EISSN: 1742-2051 ;DOI: 10.1039/c6mb00081a ;PMID: 26863937

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18
Introduction of Nonacidic Side Chains on 6-Ethylcholane Scaffolds in the Identification of Potent Bile Acid Receptor Agonists with Improved Pharmacokinetic Properties
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Article
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Introduction of Nonacidic Side Chains on 6-Ethylcholane Scaffolds in the Identification of Potent Bile Acid Receptor Agonists with Improved Pharmacokinetic Properties

Molecules (Basel, Switzerland), 2019-03, Vol.24 (6), p.1043 [Peer Reviewed Journal]

2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. ;2019 by the authors. 2019 ;ISSN: 1420-3049 ;EISSN: 1420-3049 ;DOI: 10.3390/molecules24061043 ;PMID: 30884797

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19
Protein flexibility in virtual screening: the BACE-1 case study
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Article
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Protein flexibility in virtual screening: the BACE-1 case study

Journal of chemical information and modeling, 2012-10, Vol.52 (10), p.2697 [Peer Reviewed Journal]

EISSN: 1549-960X ;DOI: 10.1021/ci300390h ;PMID: 23005250

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20
Theoretical and experimental studies on the interaction of biphenyl ligands with human and murine PD-L1: Up-to-date clues for drug design
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Article
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Theoretical and experimental studies on the interaction of biphenyl ligands with human and murine PD-L1: Up-to-date clues for drug design

Computational and structural biotechnology journal, 2023-01, Vol.21, p.3355-3368 [Peer Reviewed Journal]

2023 ;2023 Published by Elsevier B.V. on behalf of Research Network of Computational and Structural Biotechnology. ;2023 Published by Elsevier B.V. on behalf of Research Network of Computational and Structural Biotechnology. 2023 ;ISSN: 2001-0370 ;EISSN: 2001-0370 ;DOI: 10.1016/j.csbj.2023.06.006 ;PMID: 37384351

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