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Pleiotropic Effects of Statins on the Cardiovascular System

Circulation research, 2017-01, Vol.120 (1), p.229-243 [Tạp chí có phản biện]

2017 American Heart Association, Inc. ;Copyright Lippincott Williams & Wilkins Ovid Technologies Jan 6, 2017 ;ISSN: 0009-7330 ;EISSN: 1524-4571 ;DOI: 10.1161/CIRCRESAHA.116.308537 ;PMID: 28057795

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Nhan đề:
Pleiotropic Effects of Statins on the Cardiovascular System
Tác giả: Oesterle, Adam ; Laufs, Ulrich ; Liao, James K
Chủ đề: Adenine ; Animals ; Arteriosclerosis ; Cardiovascular disease ; Cardiovascular Diseases - drug therapy ; Cardiovascular Diseases - genetics ; Cardiovascular Diseases - physiopathology ; Cardiovascular system ; Cardiovascular System - drug effects ; Cardiovascular System - physiopathology ; Cell culture ; Cholesterol ; Cholesterol, LDL - antagonists & inhibitors ; Cholesterol, LDL - genetics ; Clinical Trials as Topic - methods ; Coronary artery ; Cytokines ; Fibrosis ; Genetic Pleiotropy - genetics ; GTP-binding protein ; Heart diseases ; Humans ; Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology ; Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use ; Hypertrophy ; Inflammation ; Intermediates ; Low density lipoprotein ; Molecular modelling ; NADPH-diaphorase ; Nitric oxide ; Nitric-oxide synthase ; Plaques ; Pleiotropy ; Post-translation ; Reactive oxygen species ; Rho-associated kinase ; Statins
Là 1 phần của: Circulation research, 2017-01, Vol.120 (1), p.229-243
Mô tả: The statins have been used for 30 years to prevent coronary artery disease and stroke. Their primary mechanism of action is the lowering of serum cholesterol through inhibiting hepatic cholesterol biosynthesis thereby upregulating the hepatic low-density lipoprotein (LDL) receptors and increasing the clearance of LDL-cholesterol. Statins may exert cardiovascular protective effects that are independent of LDL-cholesterol lowering called pleiotropic effects. Because statins inhibit the production of isoprenoid intermediates in the cholesterol biosynthetic pathway, the post-translational prenylation of small GTP-binding proteins such as Rho and Rac, and their downstream effectors such as Rho kinase and nicotinamide adenine dinucleotide phosphate oxidases are also inhibited. In cell culture and animal studies, these effects alter the expression of endothelial nitric oxide synthase, the stability of atherosclerotic plaques, the production of proinflammatory cytokines and reactive oxygen species, the reactivity of platelets, and the development of cardiac hypertrophy and fibrosis. The relative contributions of statin pleiotropy to clinical outcomes, however, remain a matter of debate and are hard to quantify because the degree of isoprenoid inhibition by statins correlates to some extent with the amount of LDL-cholesterol reduction. This review examines some of the currently proposed molecular mechanisms for statin pleiotropy and discusses whether they could have any clinical relevance in cardiovascular disease.
Nơi xuất bản: United States: American Heart Association, Inc
Ngôn ngữ: English
Số nhận dạng: ISSN: 0009-7330
EISSN: 1524-4571
DOI: 10.1161/CIRCRESAHA.116.308537
PMID: 28057795
Nguồn: GFMER Free Medical Journals
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Pleiotropic Effects of Statins on the Cardiovascular System

2017 American Heart Association, Inc. ;Copyright Lippincott Williams & Wilkins Ovid Technologies Jan 6, 2017 ;ISSN: 0009-7330 ;EISSN: 1524-4571 ;DOI: 10.1161/CIRCRESAHA.116.308537 ;PMID: 28057795

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