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Female Sex as a Risk Modifier for Stroke Risk in Atrial Fibrillation: Using CHA2DS2-VASc versus CHA2DS2-VA for Stroke Risk Stratification in Atrial Fibrillation: A Note of Caution

Thrombosis and haemostasis, 2020-06, Vol.120 (6), p.894-898 [Peer Reviewed Journal]

ISSN: 0340-6245 ;EISSN: 2567-689X ;DOI: 10.1055/s-0040-1710014

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  • Title:
    Female Sex as a Risk Modifier for Stroke Risk in Atrial Fibrillation: Using CHA2DS2-VASc versus CHA2DS2-VA for Stroke Risk Stratification in Atrial Fibrillation: A Note of Caution
  • Author: Nielsen, Peter Brønnum ; Overvad, Thure Filskov
  • Subjects: Review Article
  • Is Part Of: Thrombosis and haemostasis, 2020-06, Vol.120 (6), p.894-898
  • Description: Abstract Stroke prevention is a key clinical concern in the management of patients with atrial fibrillation. Oral anticoagulation treatment reduces the risk of disabling stroke, but the treatment increases the risk of bleeding. For decades, the decision to initiate oral anticoagulation has been guided by clinical risk scoring systems such as the CHADS 2 and CHA 2 DS 2 -VASc scores. In this narrative review, we focus on the recent discussion of the “Sc” (Sex Category) criterion in the CHA 2 DS 2 -VASc score. Epidemiological considerations when assessing stroke rates in cohorts are discussed, and the implications of different methodological approaches are outlined. Next, we review studies investigating the association of the “Sc” criterion on the stroke rates under various approaches. Lastly, we discuss potential consequences of implementing the recently suggested sex-less CHA 2 DS 2 -VA score, which leaves out female sex from stroke risk assessment in atrial fibrillation.
  • Publisher: Stuttgart · New York: Georg Thieme Verlag KG
  • Language: English
  • Identifier: ISSN: 0340-6245
    EISSN: 2567-689X
    DOI: 10.1055/s-0040-1710014
  • Source: Open Access: Thieme Open Access Journals
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