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A Modular Approach to Sensitized Two-Photon Patterning of Photodegradable Hydrogels

Angewandte Chemie (International ed.), 2018-11, Vol.57 (46), p.15122 [Peer Reviewed Journal]

2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim. ;ISSN: 1521-3773 ;ISSN: 1433-7851 ;EISSN: 1521-3773 ;DOI: 10.1002/anie.201808908 ;PMID: 30191643

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Title:
A Modular Approach to Sensitized Two-Photon Patterning of Photodegradable Hydrogels
Author: Lunzer, Markus ; Shi, Liyang ; Andriotis, Orestis G ; Gruber, Peter ; Markovic, Marica ; Thurner, Philipp J ; Ossipov, Dmitri ; Liska, Robert ; Ovsianikov, Aleksandr
Subjects: Benzylidene Compounds - chemistry ; Biocompatible Materials - chemistry ; biomaterials ; Cell Line ; Click Chemistry ; Humans ; hyaluronic acid ; Hyaluronic Acid - chemistry ; hydrogels ; Hydrogels - chemistry ; Medicin och hälsovetenskap ; Mesenchymal Stem Cells - cytology ; Nitrobenzenes - chemistry ; photochemistry ; Photolysis ; Photons ; Photosensitizing Agents - chemistry ; Polyethylene Glycols - chemistry ; sensitizers ; Sulfhydryl Compounds - chemistry ; Tissue Engineering
Is Part Of: Angewandte Chemie (International ed.), 2018-11, Vol.57 (46), p.15122
Description: Photodegradable hydrogels have emerged as useful platforms for research on cell function, tissue engineering, and cell delivery as their physical and chemical properties can be dynamically controlled by the use of light. The photo-induced degradation of such hydrogel systems is commonly based on the integration of photolabile o-nitrobenzyl derivatives to the hydrogel backbone, because such linkers can be cleaved by means of one- and two-photon absorption. Herein we describe a cytocompatible click-based hydrogel containing o-nitrobenzyl ester linkages between a hyaluronic acid backbone, which is photodegradable in the presence of cells. It is demonstrated for the first time that by using a cyclic benzylidene ketone-based small molecule as photosensitizer the efficiency of the two-photon degradation process can be improved significantly. Biocompatibility of both the improved two-photon micropatterning process as well as the hydrogel itself is confirmed by cell culture studies.
Publisher: Germany
Language: English
Identifier: ISSN: 1521-3773
ISSN: 1433-7851
EISSN: 1521-3773
DOI: 10.1002/anie.201808908
PMID: 30191643
Source: SWEPUB Freely available online

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A Modular Approach to Sensitized Two-Photon Patterning of Photodegradable Hydrogels

2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim. ;ISSN: 1521-3773 ;ISSN: 1433-7851 ;EISSN: 1521-3773 ;DOI: 10.1002/anie.201808908 ;PMID: 30191643

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