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Histidine-rich glycoprotein gene polymorphism in patients with recurrent miscarriage

Acta obstetricia et gynecologica Scandinavica, 2013-08, Vol.92 (8), p.974-977 [Peer Reviewed Journal]

2013 Nordic Federation of Societies of Obstetrics and Gynecology ;2013 Nordic Federation of Societies of Obstetrics and Gynecology. ;ISSN: 0001-6349 ;ISSN: 1600-0412 ;EISSN: 1600-0412 ;DOI: 10.1111/aogs.12155 ;PMID: 23672470 ;CODEN: AOGSAE

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Title:
Histidine-rich glycoprotein gene polymorphism in patients with recurrent miscarriage
Author: Lindgren, Karin E. ; Kårehed, Karin ; Karypidis, Helena ; Hosseini, Frida ; Bremme, Katarina ; Landgren, Britt-Marie ; Skjöldebrand-Sparre, Lottie ; Stavreus-Evers, Anneli ; Sundström-Poromaa, Inger ; Åkerud, Helena
Subjects: Abortion, Habitual - genetics ; Adult ; Case-Control Studies ; Female ; Genotype ; Heterozygote ; histidine-rich glycoprotein ; Humans ; infertility ; Medical research ; Medicin och hälsovetenskap ; Miscarriage ; Multivariate Analysis ; Polymorphism, Single Nucleotide ; Pregnancy ; Proteins - genetics ; recurrent miscarriage ; single nucleotide polymorphism ; Thyroid Diseases - epidemiology
Is Part Of: Acta obstetricia et gynecologica Scandinavica, 2013-08, Vol.92 (8), p.974-977
Description: Association between the histidine‐rich glycoprotein (HRG) C633T single nucleotide polymorphism (SNP) and recurrent miscarriage was investigated in a case–control study. The cases constituted 187 women with recurrent miscarriage that were compared with 395 controls who had delivered a child and had no history of miscarriage. Blood samples were collected from each woman, genomic DNA was extracted and genotyped for the HRG C633T SNP. In the whole study population, the percentage of miscarriage was the same, regardless of genotype (C/C 31.2%, C/T 32.9% and T/T 32.5%). However, an association between homozygous T/T carriers and recurrent miscarriage was detected in a subgroup of women with primary recurrent miscarriage (odds ratio 2.44, 95% CI 1.01–5.92). Our results indicate an important role for the HRG C633T SNP in the occurrence of recurrent miscarriage.
Publisher: United States: Blackwell Publishing Ltd
Language: English;French;German
Identifier: ISSN: 0001-6349
ISSN: 1600-0412
EISSN: 1600-0412
DOI: 10.1111/aogs.12155
PMID: 23672470
CODEN: AOGSAE
Source: Journals@Ovid Open Access Journal Collection Rolling
MEDLINE
Alma/SFX Local Collection

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Histidine-rich glycoprotein gene polymorphism in patients with recurrent miscarriage

2013 Nordic Federation of Societies of Obstetrics and Gynecology ;2013 Nordic Federation of Societies of Obstetrics and Gynecology. ;ISSN: 0001-6349 ;ISSN: 1600-0412 ;EISSN: 1600-0412 ;DOI: 10.1111/aogs.12155 ;PMID: 23672470 ;CODEN: AOGSAE

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