Language:

The Warburg and Crabtree effects: On the origin of cancer cell energy metabolism and of yeast glucose repression

Biochimica et biophysica acta, 2011, Vol.1807 (6), p.568 [Peer Reviewed Journal]

Copyright © 2010 Elsevier B.V. All rights reserved. ;ISSN: 0006-3002 ;EISSN: 1878-2434 ;DOI: 10.1016/j.bbabio.2010.08.010 ;PMID: 20804724

Digital Resources/Online E-Resources

Citations Cited by

Actions
1. Add to My Research
2. Remove from My Research
3. E-mail
4. Print
5. Permalink
6. Citation
7. EasyBib
8. EndNote
9. RefWorks
10. Delicious
11. Export RIS
12. Export BibTeX

Title:
The Warburg and Crabtree effects: On the origin of cancer cell energy metabolism and of yeast glucose repression
Author: Diaz-Ruiz, Rodrigo ; Rigoulet, Michel ; Devin, Anne
Subjects: Animals ; Biological Evolution ; Cells - drug effects ; Cells - metabolism ; Cells - pathology ; Down-Regulation - drug effects ; Energy Metabolism - drug effects ; Energy Metabolism - genetics ; Energy Metabolism - physiology ; Gene Expression Regulation, Fungal - drug effects ; Glucose - pharmacology ; Humans ; Medicin och hälsovetenskap ; Models, Biological ; Models, Theoretical ; Neoplasms - metabolism ; Neoplasms - pathology ; Yeasts - genetics ; Yeasts - metabolism
Is Part Of: Biochimica et biophysica acta, 2011, Vol.1807 (6), p.568
Description: During the last decades a considerable amount of research has been focused on cancer. Recently, tumor cell metabolism has been considered as a possible target for cancer therapy. It is widely accepted that tumors display enhanced glycolytic activity and impaired oxidative phosphorylation (Warburg effect). Therefore, it seems reasonable that disruption of glycolysis might be a promising candidate for specific anti-cancer therapy. Nevertheless, the concept of aerobic glycolysis as the paradigm of tumor cell metabolism has been challenged, as some tumor cells exhibit high rates of oxidative phosphorylation. Mitochondrial physiology in cancer cells is linked to the Warburg effect. Besides, its central role in apoptosis makes this organelle a promising "dual hit target" to selectively eliminate tumor cells. From a metabolic point of view, the fermenting yeast Saccharomyces cerevisiae and tumor cells share several features. In this paper we will review these common metabolic properties as well as the possible origins of the Crabtree and Warburg effects.
Publisher: Netherlands
Language: English
Identifier: ISSN: 0006-3002
EISSN: 1878-2434
DOI: 10.1016/j.bbabio.2010.08.010
PMID: 20804724
Source: SWEPUB Freely available online

Back to results list


INSPIRE LIBRARY - TON DUC THANG UNIVERSITY	(84-028) 37 755 057	Feedback
19 Nguyen Huu Tho St. Dist.7, HCM	thuvien@tdtu.edu.vn	Feedback

The Warburg and Crabtree effects: On the origin of cancer cell energy metabolism and of yeast glucose repression

Copyright © 2010 Elsevier B.V. All rights reserved. ;ISSN: 0006-3002 ;EISSN: 1878-2434 ;DOI: 10.1016/j.bbabio.2010.08.010 ;PMID: 20804724

Searching Remote Databases, Please Wait